NC_000002.11:g.234668881_234668882TA[5][6][7][8] AND atazanavir and ritonavir response - Toxicity/ADR - ClinVar

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NC_000002.11:g.234668881_234668882TA[5][6][7][8] AND atazanavir and ritonavir response - Toxicity/ADR

Germline classification:: drug response (1 submission)
Last evaluated:: Jun 1, 2016
Review status:: 3 stars out of maximum of 4 stars
reviewed by expert panel

Somatic classification of clinical impact:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of oncogenicity:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Record status:: current
Accession:: RCV000211183.2

Allele description

NC_000002.11:g.234668881_234668882TA[5][6][7][8]

Genes:

UGT1A1:UDP glucuronosyltransferase family 1 member A1 [Gene - OMIM - HGNC]
UGT1A:UDP glucuronosyltransferase family 1 member A complex locus [Gene - HGNC]
UGT1A10:UDP glucuronosyltransferase family 1 member A10 [Gene - OMIM - HGNC]
UGT1A3:UDP glucuronosyltransferase family 1 member A3 [Gene - OMIM - HGNC]
UGT1A4:UDP glucuronosyltransferase family 1 member A4 [Gene - OMIM - HGNC]
UGT1A5:UDP glucuronosyltransferase family 1 member A5 [Gene - OMIM - HGNC]
UGT1A6:UDP glucuronosyltransferase family 1 member A6 [Gene - OMIM - HGNC]
UGT1A7:UDP glucuronosyltransferase family 1 member A7 [Gene - OMIM - HGNC]
UGT1A8:UDP glucuronosyltransferase family 1 member A8 [Gene - OMIM - HGNC]
UGT1A9:UDP glucuronosyltransferase family 1 member A9 [Gene - OMIM - HGNC]

Variant type:

Microsatellite

Cytogenetic location:

2q37.1

Genomic location:

Preferred name:

NC_000002.11:g.234668881_234668882TA[5][6][7][8]

HGVS:

NC_000002.11:g.234668881_234668882TA[5][6][7][8]
NC_000002.11:g.234668881_234668882TA[5][6][7][8]
NC_000002.12:g.233760235_233760236TA[5][6][7][8]

Links:

PharmGKB: 981750843; PharmGKB: 981750843PA450085; PharmGKB: 982047507; PharmGKB: 982047930; PharmGKB: 982047930PA165110775; PharmGKB Clinical Annotation: 981750843; PharmGKB Clinical Annotation: 982047507; PharmGKB Clinical Annotation: 982047930

Condition(s)

Name:: atazanavir and ritonavir response - Toxicity/ADR
Identifiers:: MedGen: CN236470

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Submission Accession	Submitter	Review Status (Assertion method)	Clinical Significance (Last evaluated)	Origin	Method	Citations
SCV000268414	PharmGKB	reviewed by expert panel (Pharmacogenomics knowledge for personalized medicine)	drug response (Jun 1, 2016) Condition: atazanavir and ritonavir response - Toxicity/ADR Drug reported used for: HIV	germline	curation	PubMed (15) [See all records that cite these PMIDs] 16170755, 17058217, 17148966, 19710077, 20504240, 21288825, 21317582, 21348813, 22179231, 22661571, 23148286, 23548653, 24516079, 26857335, 22992668 Citation Link

Submission Accession

Submitter

Review Status
(Assertion method)

Clinical Significance
(Last evaluated)

Origin

Method

Citations

SCV000268414

PharmGKB

reviewed by expert panel

(Pharmacogenomics knowledge for personalized medicine)

drug response
(Jun 1, 2016)
Condition: atazanavir and ritonavir response - Toxicity/ADR
Drug reported used for: HIV

germline

curation

PubMed (15)
[See all records that cite these PMIDs]

Citation Link

Help

Summary from all submissions

Ethnicity	Origin	Affected	Individuals	Families	Chromosomes tested	Number Tested	Family history	Method
not provided	germline	yes	not provided	not provided	not provided	not provided	not provided	curation

Citations

PubMed

Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia.

Rotger M, Taffe P, Bleiber G, Gunthard HF, Furrer H, Vernazza P, Drechsler H, Bernasconi E, Rickenbach M, Telenti A; Swiss HIV Cohort Study..

J Infect Dis. 2005 Oct 15;192(8):1381-6. Epub 2005 Sep 9.

PubMed [citation]

PMID:: 16170755

Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype.

Lankisch TO, Moebius U, Wehmeier M, Behrens G, Manns MP, Schmidt RE, Strassburg CP.

Hepatology. 2006 Nov;44(5):1324-32.

PubMed [citation]

PMID:: 17058217

See all PubMed Citations (15)

Details of each submission

From PharmGKB, SCV000268414.3

#	Ethnicity	Individuals	Chromosomes Tested	Family History	Method	Citations
1	not provided	not provided	not provided	not provided	curation	PubMed (15)

Description

PharmGKB Level of Evidence 1A: Annotation for a variant-drug combination in a CPIC or medical society-endorsed PGx guideline, or implemented at a PGRN site or in another major health system.

#	Sample				Method		Observation
#	Origin	Affected	Number tested	Tissue	Purpose	Method	Individuals	Allele frequency	Families	Co-occurrences
1	germline	yes	not provided	not provided	not provided		not provided	not provided	not provided	not provided

Last Updated: Nov 29, 2021

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