ClinVar (all) for Orgtrack (Select 504197) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 254634	NM_000059.4(BRCA2):c.9429_9430del (p.Ser3144fs)	BRCA2 (S3144fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254626	NM_000059.4(BRCA2):c.8648del (p.Pro2883fs)	BRCA2 (P2883fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254619	NM_000059.4(BRCA2):c.8012_8034del (p.Ala2671fs)	BRCA2 (A2671fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254597	NM_000059.4(BRCA2):c.7109_7110del (p.Lys2370fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254587	NM_000059.4(BRCA2):c.6645_6649del (p.Tyr2215_Lys2217delinsTer)	BRCA2	Deletion (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254582	NM_000059.4(BRCA2):c.6434del (p.Asn2145fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254577	NM_000059.4(BRCA2):c.6239del (p.Val2079_Leu2080insTer)	BRCA2	Deletion (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254566	NM_000059.4(BRCA2):c.5891del (p.Lys1964fs)	BRCA2 (K1964fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254563	NM_000059.4(BRCA2):c.5720_5723del (p.Asn1906_Ser1907insTer)	BRCA2	Microsatellite (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254562	NM_000059.4(BRCA2):c.5655_5656dup (p.Gln1886fs)	BRCA2 (Q1886fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254551	NM_000059.4(BRCA2):c.5132_5135del (p.Val1711fs)	BRCA2 (V1711fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254549	NM_000059.4(BRCA2):c.5070_5073del (p.Lys1690fs)	BRCA2 (K1690fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254529	NM_000059.4(BRCA2):c.3957_3960del (p.Asn1319fs)	BRCA2 (N1319fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254520	NM_000059.4(BRCA2):c.3639del (p.Val1214fs)	BRCA2 (V1214fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254517	NM_000059.4(BRCA2):c.3455dup (p.Leu1152fs)	BRCA2 (L1152fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254516	NM_000059.4(BRCA2):c.3295del (p.Ser1099fs)	BRCA2 (S1099fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254496	NM_000059.4(BRCA2):c.2085_2089del (p.Glu696fs)	BRCA2 (E696fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 254478	NM_000059.4(BRCA2):c.541del (p.Ser181fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 184841	NM_000059.4(BRCA2):c.5934dup (p.Ser1979Ter)	BRCA2 (S1979*)	Duplication (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 132782	NM_000059.4(BRCA2):c.1909+22del	BRCA2	Deletion	not specified +4 more	GConflicting classifications of pathogenicity
Select item 126217	NM_000059.4(BRCA2):c.9672dup (p.Tyr3225fs)	BRCA2 (Y3225fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126216	NM_000059.4(BRCA2):c.9649-6dup	BRCA2	Duplication (intron variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 126215	U43746.1:n.9877-68_9877-65delTTAC	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126214	NM_000059.4(BRCA2):c.9513_9515del (p.Leu3172del)	BRCA2 (L3172del)	Deletion (inframe_deletion)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 126213	NM_000059.4(BRCA2):c.9455_9456dup (p.Gly3153fs)	BRCA2 (G3153fs)	Microsatellite (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126212	NM_000059.4(BRCA2):c.9449C>T (p.Pro3150Leu)	BRCA2 (P3150L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 126211	NM_000059.4(BRCA2):c.9401G>T (p.Gly3134Val)	BRCA2 (G3134V)	Single nucleotide variant (missense variant)	Familial cancer of breast +3 more	GUncertain significance
Select item 126210	NM_000059.4(BRCA2):c.9384_9385insG (p.Pro3129fs)	BRCA2 (P3129fs)	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126209	NM_000059.3(BRCA2):c.9330_9334delTGAGGins3	BRCA2	Indel	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126207	NM_000059.4(BRCA2):c.9257-83G>A	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126206	NM_000059.4(BRCA2):c.9257-19_9257-17delinsCC	BRCA2	Indel (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126205	NM_000059.4(BRCA2):c.9256+16G>C	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126204	U43746.1:n.9476_9491del16	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126203	NM_000059.4(BRCA2):c.9227G>T (p.Gly3076Val)	BRCA2 (G3076V)	Single nucleotide variant (missense variant)	BRCA2-related cancer predisposition	GPathogenicFDA Recognized database
Select item 126202	NM_000059.4(BRCA2):c.714_716dup (p.Glu238_Ser239insArg)	BRCA2	Duplication (inframe_insertion)	Breast-ovarian cancer, familial, susceptibility to, 2 +5 more	GConflicting classifications of pathogenicity
Select item 126201	NM_000059.4(BRCA2):c.9113_9115dup (p.Leu3038dup)	BRCA2	Duplication (inframe_insertion)	Breast-ovarian cancer, familial, susceptibility to, 2 +11 more	GConflicting classifications of pathogenicity
Select item 126200	NM_000059.4(BRCA2):c.9098dup (p.Gln3034fs)	BRCA2 (Q3034fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126199	NM_000059.4(BRCA2):c.9082G>C (p.Ala3028Pro)	BRCA2 (A3028P)	Single nucleotide variant (missense variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 126198	NM_000059.4(BRCA2):c.9066_9067insAA (p.Ala3023fs)	BRCA2 (A3023fs)	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126197	U43746.1:n.9279+1G>A	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126195	NM_000059.4(BRCA2):c.8969G>A (p.Trp2990Ter)	BRCA2 (W2990X)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126194	NM_000059.4(BRCA2):c.8954-1delinsAA	BRCA2	Indel (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126193	U43746.1:n.9176_9186del11	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126192	NM_000059.4(BRCA2):c.681+56C>T	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126191	NM_000059.3(BRCA2):c.8800_8801ins346 (p.?)	BRCA2	Insertion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126190	NM_000059.4(BRCA2):c.8755-66T>C	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126189	NM_000059.4(BRCA2):c.8745_8748dup (p.Glu2918fs)	BRCA2 (E2918fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126188	NM_000059.4(BRCA2):c.8722G>A (p.Val2908Met)	BRCA2 (V2908M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 126187	U43746.1:n.886_887delGC	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126185	U43746.1:n.8861-24_del26	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126183	NM_000059.4(BRCA2):c.8578_8579del (p.Lys2860fs)	BRCA2 (K2860fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126181	NM_000059.4(BRCA2):c.8525G>T (p.Arg2842Leu)	BRCA2 (R2842L)	Single nucleotide variant (missense variant)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 126180	U43746.1:n.8715A>G	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126179	NM_000059.4(BRCA2):c.8487+47C>T	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126178	NM_000059.4(BRCA2):c.8487+19A>G	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126177	NM_000059.3(BRCA2):c.8483_8484ins11 (p.?)	BRCA2	Insertion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126175	U43746.1:n.8560_8860del301	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126174	NM_000059.4(BRCA2):c.8323dup (p.Met2775fs)	BRCA2 (M2775fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126173	NM_000059.3(BRCA2):c.8278_8279ins71 (p.?)	BRCA2	Insertion	not provided +1 more	GPathogenic
Select item 126170	NM_000059.4(BRCA2):c.8219dup (p.Leu2740fs)	BRCA2 (L2740fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126169	NM_000059.4(BRCA2):c.8208_8209insAG (p.Leu2737fs)	BRCA2 (L2737fs)	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126168	NM_000059.4(BRCA2):c.8188G>C (p.Ala2730Pro)	BRCA2 (A2730P)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 126167	NM_000059.4(BRCA2):c.8187G>A (p.Lys2729=)	BRCA2	Single nucleotide variant (synonymous variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GLikely benign
Select item 126166	U43746.1:n.8397dupTGGG	BRCA2	Duplication	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126164	NM_000059.4(BRCA2):c.7977-2A>T	BRCA2	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126163	NM_000059.4(BRCA2):c.7977-1G>T	BRCA2	Single nucleotide variant (splice acceptor variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic/Likely pathogenic
Select item 126162	U43746.1(BRCA2):n.8149_8154del6insAG	BRCA2	Indel	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126160	NM_000059.4(BRCA2):c.7816_7819dup (p.Thr2607fs)	BRCA2 (T2607fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126159	U43746.1:n.8034-16T>C	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126158	NM_000059.4(BRCA2):c.7806-14T>C	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126157	NM_000059.4(BRCA2):c.7791dup (p.Glu2598fs)	BRCA2 (E2598fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126156	NM_000059.4(BRCA2):c.7764A>T (p.Ile2588=)	BRCA2	Single nucleotide variant (synonymous variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GLikely benign
Select item 126155	NM_000059.4(BRCA2):c.7719dup (p.Trp2574fs)	BRCA2 (W2574fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126154	NM_000059.3(BRCA2):c.7662_7663ins37 (p.?)	BRCA2	Insertion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126153	NM_000059.4(BRCA2):c.7627dup (p.Tyr2543fs)	BRCA2 (Y2543fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126152	U43746.1:n.7830-27T>A	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126151	U43746.1:n.7830-1G>A	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126150	U43746.1:n.7830-16T>G	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126149	U43746.1:n.7830-15T>G	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126148	U43746.1:n.7830-114_7830-112delAGT	BRCA2	Deletion	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126147	U43746.1:n.7829+4T>C	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126146	U43746.1:n.7829+2T>G	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126145	U43746.1:n.7829+1G>T	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126144	U43746.1:n.7829+1G>A	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126143	U43746.1:n.7829+18T>G	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126142	U43746.1:n.7829+17C>T	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 126141	NM_000059.4(BRCA2):c.7596_7609del (p.Pro2532_Ser2533insTer)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126140	NM_000059.4(BRCA2):c.7595_7596insTT (p.Ala2534fs)	BRCA2 (A2534fs)	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126139	NM_000059.4(BRCA2):c.7505G>C (p.Arg2502Pro)	BRCA2 (R2502P)	Single nucleotide variant (missense variant)	not specified +2 more	GUncertain significance
Select item 126138	NM_000059.4(BRCA2):c.7487A>C (p.Lys2496Thr)	BRCA2 (K2496T)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 126137	U43746.1(BRCA2):n.7696_7697insT	BRCA2	Duplication	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126136	NM_000059.4(BRCA2):c.7435+53C>T	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126135	NM_000059.4(BRCA2):c.7379_7380insG (p.Asn2460fs)	BRCA2 (N2460fs)	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126134	NM_000059.4(BRCA2):c.7283del (p.Leu2428fs)	BRCA2 (L2428fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126133	NM_000059.4(BRCA2):c.7242A>G (p.Ser2414=)	BRCA2	Single nucleotide variant (synonymous variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126132	NM_000059.4(BRCA2):c.7235_7236insG (p.Thr2412_Lys2413insTer)	BRCA2	Insertion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 126130	NM_000059.4(BRCA2):c.502C>G (p.Pro168Ala)	BRCA2 (P168A)	Single nucleotide variant (missense variant)	not specified +3 more	GUncertain significance
Select item 126129	NM_000059.4(BRCA2):c.7072T>C (p.Ser2358Pro)	BRCA2 (S2358P)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +9 more	GUncertain significance
Select item 126128	NM_000059.4(BRCA2):c.7052C>T (p.Ala2351Val)	BRCA2 (A2351V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 126126	NM_000059.4(BRCA2):c.496C>T (p.His166Tyr)	BRCA2 (H166Y)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance

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