Conserved Protein Domain Family
PTP_DSP_cys

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cl28904: PTP_DSP_cys Superfamily 
cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
This superfamily is composed of cys-based phosphatases, which includes classical protein tyrosine phosphatases (PTPs) as well as dual-specificity phosphatases (DUSPs or DSPs). They are characterized by a CxxxxxR conserved catalytic loop (where C is the catalytic cysteine, x is any amino acid, and R is an arginine). PTPs are part of the tyrosine phosphorylation/dephosphorylation regulatory mechanism, and are important in the response of the cells to physiologic and pathologic changes in their environment. DUSPs show more substrate diversity (including RNA and lipids) and include pTyr, pSer, and pThr phosphatases.
Links
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Taxonomy: root
PubMed: 1131 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl28904
PSSM Id: 475123
Name: PTP_DSP_cys
Created: 19-Sep-2018
Updated: 4-Oct-2023
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