1F6T,1NUE,2NCK,1NB2,1NDK,2AZ3,1WKL,1EHW,1PKU,1XIQ,1NSQ,1BE4,1S59,1UCN,1ZS6,1U8W,1W7W,2CWK,1K44,1NHK,1XQI


Conserved Protein Domain Family
NDPk_I
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cd04413: NDPk_I 
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Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.
Links
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Statistics
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PSSM-Id: 239876
Aligned: 105 rows
Threshold Bit Score: 159.556
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitemultimer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:NDKs possess the active site motif N-x-x-H-[GA]-S-D.
  • Comment:His residue is phosphorylated during catalysis
  • Structure:1NUE_A: Homo sapiens NDP kinase complexed with GDP
    - View structure with Cn3D
  • Citation:PMID 8747457
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                         #       #                      
1F6T_A        9 ERTFLAVKPDGVArgLVGEIIARYEK--KGFVLvGLKQLvpTKDLAESHYaehkerpFFGGLVSFITs----------gP 76  Dictyostelium di...
1NUE_A        4 ERTFIAIKPDGVQrgLVGEIIKRFEQ--KGFRLvAMKFLraSEEHLKQHYidlkdrpFFPGLVKYMNs----------gP 71  human
Q8XIZ1        4 EKSLVLIKPDAVErnLIGKILEVYEG--AGLKIkAMEMKqiNKEFAEKHYeehrdkqFFNSLIKYITr----------sP 71  Clostridium perf...
ZP_00667483   6 QQTLVLIKPDALKnsLTGYVLSQFSEfhTGLTFaGTKVVhvTRMLAEEHYaehrgkvFFPALIEMITghlhypgepdkqR 85  Syntrophobacter ...
XP_626094    89 ERTLVLFKPEVTHrgLIGEILSQIER--KGFKIaAMKFLvaTAQQIEAHYsdhagkpFFESLVSRTTn----------qP 156 Cryptosporidium ...
O26358        3 EKSFVMLKPDAVKrrLAGRIIARFED--RGLKIvAFKMLqiPEDLAMEHYqehrekpFFRDLVDYITs----------aP 70  Methanothermobac...
Q3Z9G0        2 ERTLLLVKPDGVNrgLSGEILGRMEK--LGLKMiGLRMLqmDAVLADKHYaphrerpFFKDLVTYITs----------gP 69  Dehalococcoides ...
Q8EYP5        2 SRTFIMIKPDGVKnkHVGNILSRIEK--EGFKIlGLKYLklSLEDAKQFYkvhsarpFYNDLCNYMSs----------gP 69  Leptospira inter...
Q2S3M6        4 ERTLAILKPDCVRkeKVGEVLRRIQD--AGFQLcAMKMItmSKAEAEGFYavhedkpFFDDLTDFMSs----------gP 71  Salinibacter rub...
ZP_01051602   6 NRTFTMIKPDGVEngHIGAILEKITA--SGFRIvAMKLTqmTKADAETFYavhnerpFFGELVEFMTr----------gP 73  Cellulophaga sp....

Feature 1                      #     #             #                     #  # ##       #     
1F6T_A       77 VVAMVFEGkGVVASARLMIGVTNPl---aSAPGSIRGDFGvd------------vgRNIIHGSDSvESANREIALWF 138 Dictyostelium disco...
1NUE_A       72 VVAMVWEGlNVVKTGRVMLGETNPa---dSKPGTIRGDFCiq------------vgRNIIHGSDSvKSAEKEISLWF 133 human
Q8XIZ1       72 LVALILEGeDAINKIRSLNGATNPe---kAEFGTIRRRFAls------------gtENSVHASDSiESAEKEIKLWF 133 Clostridium perfrin...
ZP_00667483  86 VIAIVYKGpDVIRKVREICGPTNPhvardEKPGCVRSLGTvvalkdaqgnivgdrmDNLIHASATpEEAEREIKLWF 162 Syntrophobacter fum...
XP_626094   157 IVAMVLEGlNVISEFRRFMGSTDPk---kSEMGTLRAQFGmq------------teRNLIHASDSvENANLEIFLWF 218 Cryptosporidium par...
O26358       71 VIAMVIEGkDCISLIRKMVGATNPa---eADLGTIRGDFAle------------tgRNIIHASDSpESAEREIKLFF 132 Methanothermobacter...
Q3Z9G0       70 IVAAVFEGeNAVEKMRKAMGATDPa---kSEKGTVRGDLGin------------ieQNTVHGSDSaENAKHEISLFF 131 Dehalococcoides eth...
Q8EYP5       70 IVAAALERdNAVLHWREVIGATDPk---eAAAGTIRALYAes------------keANAVHGSDSdDNAALEISFFF 131 Leptospira interrogans
Q2S3M6       72 CVPVVLEKeNAIADFRELIGATDPd---eAAEGTIRSDFAgs------------iqENIVHGSDSpSNGQKEAGYFF 133 Salinibacter ruber ...
ZP_01051602  74 IVAAVLEKeNAVADFRTLIGATNPa---dAAEGTIRALYAts------------mgENAVHGSDSdENAAIESAFHF 135 Cellulophaga sp. ME...

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