1RWI


Conserved Protein Domain Family
NHL_PKND_like
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cd14952: NHL_PKND_like 
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NHL repeat domain of the protein kinase PknD
PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Links
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Statistics
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PSSM-Id: 271322
Aligned: 38 rows
Threshold Bit Score: 265.996
Created: 19-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:NHL repeat [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ####### ############     #########  ######                        
1RWI_A        12 QTVLPFTGIDfrlsPSGVAVDsAGNVYVTSEGMYg----RVVKLATGStgTTVLPFnglyQPQGLAVDGAGTVYVTDf-- 85  Mycobacterium t...
YP_704229    358 QVVLPLTGLQg---PAGLTVSgTGDLYIADSAAK-----QVLKVSAGTyeQTVLPFtgleVPQGVAVSASGDVYVSDl-- 427 Rhodococcus sp....
YP_007290065 307 SSELPFTPLRy---ANGVSADtSGNLYISGEGDH-----RVWKLAAGAdaPAPLPFsdktDAGSTAVDSAGNLYVTDf-- 376 Mycobacterium s...
YP_007290065  54 QAVLPFAHVDk---PYGAAVDaAGNLYIADHASH-----QLLKLAAGAdaPTPLPStglsAPTGVAVDSAGNVYVADn-- 123 Mycobacterium s...
YP_004999205 368 QVALPFPELRv---AGGIDVDpGGNAYVTGIGTD-----VVWRLDAGAaaATRLPFsglkNPHDVAVDGKGDVYVTDs-- 437 Mycobacterium r...
WP_019971667 353 QTPLGFVDVHl---ATGVAVDgTGDVYVTDIGTD-----RVLRLLAGRetADTLPFsglkNPRDVAVDSAGDVFVADs-- 422 Mycobacterium s...
YP_007290641  42 PIELPFGSLHg---PQGVAVDgNGNVYIADVATDia-dnQVLKMSAAHtgAAKLPFtg-aGPVSVAVDSTGTLYATDy-- 114 Mycobacterium s...
WP_005082967 443 QSVLPFTELSy---PWDIAVDaAGAVYVVDSDTVhe-tsRVLSLPVGAtaPSTLPFe--pGRNGVAVDAAGTVYVNNg-- 514 Mycobacterium a...
WP_019927516 306 QLLLPFSGLNf---PMRVAVDtGGNVYVADAGNN-----RVLQLPAGSsaQITLPIt--aTPQSIAVDAAGDVFVADg-- 373 Nocardia sp. BM...
WP_020103939  36 QSVLPFTGLNg---PYDVAVDaADNVFVSDVPAGrngvnRVIELPAGSnaQKVLPF----ARATVMTNPAGEVWVIDggh 108 Mycobacterium s...

Feature 1                                                                                        
1RWI_A        86 -NNRVVTLAAGSNnQTVLPFDGLn---yPEGLAVDTQGAVYVADr----------gNNRVVKLAAGSKTQTVLPFtgLND 151 Mycobacterium t...
YP_704229    428 -VTNTVTMLHGST-QVPLPFAGLd---qPFGIALGPDATLYVADt----------lNNRVMSLHDVTAAPVAVPLt-VIG 491 Rhodococcus sp....
YP_007290065 377 dNHQVLKLAAGATnPAPLPLAGVe---yPTSVAVDATGDLYISDw----------dGNRVWKLAAGAATPIALPFddLRD 443 Mycobacterium s...
YP_007290065 124 gNDRLWKLAAGADkLTALPLRGLt---dPDGVAVDAEGNVYVADy----------sNRRVLKLAPGASIASVLPLgtLHG 190 Mycobacterium s...
YP_004999205 438 sNDRVMWLPAGATaAATLPFTGLn---dPRGVIVSPAGDVYVVDg----------gNDRVLYLEAGATTATTLPFadLND 504 Mycobacterium r...
WP_019971667 423 gNDRVLRLAAGAPaATPLPFIGLn---dPRGVAVNAAGDVFVTDr----------gNDRVLRLDKGSATPTALPFtgLND 489 Mycobacterium s...
YP_007290641 115 vNDRVLKLAPGASnTTELSIAGLn---rPSGIAVDGGGNVYVADt----------yNDRVLKISGGDANAVELPFagLSK 181 Mycobacterium s...
WP_005082967 515 -YDGVQVLTAGSStPTKLSFPGQh----GHGVAVDTAGTVYVAD------------KGRVLSRAAGEAPPIELPFtgLDE 577 Mycobacterium a...
WP_019927516 374 kHDRVLRLAAGALaTTTLPITGT-----PTSVAVDAAGDVYVLDi----------aSETVLRLAAGASAPSTVPFphLTN 438 Nocardia sp. BM...
WP_020103939 109 sPSHLVKLAHDGEqQTVLPMPDLgreyrGVIQAVDAVGGFYGMVgggedsgrrcclPVQVAKQAPGSNAPAALPFqhMSV 188 Mycobacterium s...

Feature 1                                                                                        
1RWI_A       152 PDGVAVDNsGNVYVTDt----------------dNNRVVKLEAESNnQVVLPFTDIt---APWGIAVDEAGtVYVTEHnt 212 Mycobacterium t...
YP_704229    492 PFAVAVSEhGDLYVGT------------------PNKVLAWNAATHaQSYLPFTDLq---SVGGVAVDDEGtVYAIDQnh 550 Rhodococcus sp....
YP_007290065 444 PQGVAVDPaGNVYVVDs----------------gNNRVLKLAAAENsATALPFTGLd---DPAGVALDSVGdLYVADRgn 504 Mycobacterium s...
YP_007290065 191 PAAVAVDAaNAVYVVDh----------------dANRVLKLAAGASgPTVLPFGTLh---NPIAVGVDRQNnVYVLQPnp 251 Mycobacterium s...
YP_004999205 505 PHGVAVDPaGGVVVTDt----------------gNNRVMQLAAGSTePRALPFTGVn---DPHGVAVDSKGnVYVTDRgn 565 Mycobacterium r...
WP_019971667 490 PRGVAVDAvGDVVVTDt----------------gNNRVLQLAAGAAaPTVLPFASLn---DPQGIAIDARHnVYITDRgn 550 Mycobacterium s...
YP_007290641 182 PFGVAVDTaDNVYVADs----------------hNNRVLKLGGGTSdPTELPFTDLh---GPNGIAVDKAGtVYVTGYgd 242 Mycobacterium s...
WP_005082967 578 ATFVTVDAaGTVYVLDq----------------vRKRILSLRSGSTtQSEFPLTGLk---GPSGLAVDSRGtIYVADYtg 638 Mycobacterium a...
WP_019927516 439 PVAVAADPaGDVYVLDtggawtdtaghshfatpdANRVLRLAAGSStPTTLPFTGDaapsSTFVLAVDAVGgVYVEDRag 518 Nocardia sp. BM...
WP_020103939 189 AAGMTVDAaGNLYVGDp----------------vGKRVLKLAPGASsPSELPFHALr---SVIDIAVDAKSaVYVVDGqq 249 Mycobacterium s...

Feature 1                                                                
1RWI_A       213 NQVVKLlAGSTTSTVLPFt-gLNTPLAVAVDSd-RTVYVADRg-----NDRVVKLT 261 Mycobacterium tuberculosis
YP_704229    551 NRILRLaAGSDEQEVLPFs-eLDQPEGIAVSSr-GDVYVADTd-----NSRVVMLP 599 Rhodococcus sp. RHA1
YP_007290065 505 NRVLKLaAGSNTPAALPFs-gLNLPQSLSVDAn-GTVYVTDNg-----NGRVVKLS 553 Mycobacterium smegmatis JS623
YP_007290065 252 DAVLKLtPNATAPTKLPFfssSNENAGLAVSPs-GDLYITDLs-----KHKVEKLQ 301 Mycobacterium smegmatis JS623
YP_004999205 566 AGIVELgPSAPAAIPLPFt-gLNDPQGVAVDDa-GNVYVTDVg-----PNLVVKLS 614 Mycobacterium rhodesiae NBB3
WP_019971667 551 AGVLQLrPDAPGAIPLPFt-gLNDPQGVAVDGi-GDVYVTDVg-----ATPVVKLP 599 Mycobacterium sp. 141
YP_007290641 243 GRVSKLaAGEASSTDVPVs-gLKKPWGVAVGSd-GDVYVTDYg-----NRRVLELN 291 Mycobacterium smegmatis JS623
WP_005082967 639 GKVVAFaAGSHATTVLPFt-gLRGPLDVAVDAd-GNVYVSGYvdfsddSGQVLKLP 692 Mycobacterium abscessus
WP_019927516 519 NGIRRLtAGASTSTVLPA---TFAGDSIAVDAtgADIYVVEHy-----SKDVWQLA 566 Nocardia sp. BMG111209
WP_020103939 250 NRVLKLdPGASAPTVLPFt-gLKGPVSIAVGTt-GAVYVVDDg-----NRRIVKLE 298 Mycobacterium sp. 360MFTsu5.1

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