Conserved Protein Domain Family
Ran-binding

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pfam05508: Ran-binding 
RanGTP-binding protein
The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins.
Statistics
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PSSM-Id: 428501
Aligned: 77 rows
Threshold Bit Score: 292.875
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003718619   1 MDAFLTRLGAQAMN----MAIRSGIALTSTYAVQQCARLLKTVd-DKSiRTELRLLQQELNERIKIISPAIDLIEFKAGR 75 
XP_001482576   1 MDQLLARAGSQAVT----FAIRLGITFASGYAVRTVTKFLDKIpeSEK--KKILDKRTKIRIKTDILGQAMDLIRLAAVR 74 
EGV63282       1 MDDFITKASSQAVS----FAIRSGISLASGYAIRTVTKFVDKIpeKDK--AQLNNKIHRVKLQINIVSPSIELIKSMNAG 74 
XP_002172067   1 MDQLLTKVTSSAATyataFAIRSGIQWAGSLAARRLSKYIHKTtsERS-QYSLELVKSRLEQKIRAITPAIDLIELIAAR 79 
EPY49687       1 MDQIFTKVTASAATyataYAIRTGVNWAGSLAAKRLTKFIQQSapESS-QYNLDLVKSRLEQKILAITPAVDLIELIAAR 79 
Q09721         1 MDQVLSKVTTTAATyataYAVRTGLQLAGSLVAKRFSKYIQTSapKSS-QFNLELVKSRLEQKIQAITPAVDLIQLVAAR 79  Schizosaccharom...
CCG84378       1 MDALLASAARYSAG----LAIRSGISIAGGFAIRQVSTYISKVpqNLH-VQELELISKRLDQKIKIVTPAIDLIEIIAAR 75 
XP_002172940   1 MDELL-HVASHAATfattFAIKRSISFASKLAIQQVSSYIKKVptDHR--ASLENEKAKLLEIIRVVTPAIELIEIISAT 77 
O94589         1 MDELL-NVASHAATfatnFALKHSISFAGKLAVQQVSSYIKRAsaDDQ--SELESVKTQLLEMIRVVTPAIELIEIMSVG 77  Schizosaccharom...
EPY51322       1 MDELF-HVASHAATfatsFAIKHSISFAGKFAVQQVSSYIKRIpdADR--NELEFMKAKLLEMIRVVTPAIELIDIMSSS 77 
XP_003718619  76 GNVFLENAVPLAKGLRRSIVALGKRLEDVACAEEEAQQhareararprtPESQAAELRSIICEMKTLLGRIERDAHMLQF 155
XP_001482576  75 GNTSLEPSLELIEAVTSEIERFETKMSSITETLS---------------SLNEKESVIEVNRCMDNLLTQLDEAIPLLQL 139
EGV63282      75 GFSSLQSCNELIDQMTQSFREFDDMVEKWSDQLS---------------NSNTGDVIKQVNKQLDGLIDMIDQTVPLLNL 139
XP_002172067  80 GNSSLQNLVPLIIRLRGNIDNFNDTLAEYTNMSPPSS------------EQAASARCDEVQKSCEQLLSSIEQAIPLINL 147
EPY49687      80 GNSSLQNLVPLIQRLRDHIDEFSEYVNEKDSLSPD--------------EENLEEASKDIYTSCESLLKEIEQTIPLINL 145
Q09721        80 GNSSLQNLVPLIIRLRDHIDDFLEFIDYEASGSEKKS------------PEKADEASEKIFRRCEVLLREIEETIPLINL 147 Schizosaccharom...
CCG84378      76 GNTTLNSTVQLTVSLRNDINAFGQRMADVMSEEPSP-------------HTGSKEATRKVLDDMKSLLARIEDAVPLISL 142
XP_002172940  78 GNPSFASTRELVETLRSDITHFIQTISGAFAMEEDK-------------PTTEKRTTATVLREIETLLLCIQDAIPLLNL 144
O94589        78 ENENFKSTKQLVDSLHADIEQFTKHVLSAAHSEFPPSSe---------kETLQKNVDTSILREMKTLLLKINDAVPLLNL 148 Schizosaccharom...
EPY51322      78 GNQSLQSTRQLVDALRSDIEKFSVHILGVASSDSGEEAs---------nPKRAEETKGKVLQEIKTLLLRIQDAIPLLNL 148
XP_003718619 156 AISASGENLSTSLPPGVSPSRLMQASTFLSIGDTQFASDPY-GPVQIGPSFTLSLYLLFMGHSkTETRARPAqgnaltti 234
XP_001482576 140 SIATSGTTMKTSLSPSVSPGRLLQASSLVAKA------NESkLPCNVGPVFDLVYYSVFYNPSrLKYIDHEDnkkvdv-- 211
EGV63282     140 CIVTSGINLNRDLSEEISINKLIEASNIILGSr---------DSTNTGPVFDLTFFSVFYNPSrLKYIEHESgnq----- 205
XP_002172067 148 ALTTSGVSLSSTVTDTISPSRLLQAASFLELADEKFKSKSS-ANIRVGPPFDMILYTIFSGHSrGATANDDAi------- 219
EPY49687     146 SLTTSGVTLSSALKESLSPSRLLQAQAFLELSDKQFEETQ--KDVQIGPKFVLTLYNTFHRSNqSDGPSD---------- 213
Q09721       148 SLTTAGITLNTALSNTISPSRLLQAQCFLELSDKRFE-ESH-TEIQIGPKFTVVLYTSFSQPSkSDGPLD---------- 215 Schizosaccharom...
CCG84378     143 ALTTSGANLSATLPDTVSPSRLLQASAFLQQADKQFDTKSL-QEVQVGPSFSLKLYTIFEGHSrQSQDSNVTn------- 214
XP_002172940 145 SLTTSGVSISSSLPQTTSFSNLLLANSYMRKCNLKFNG----EPCLLGPKFNIKLYTIFEGHAnSKYLSKDTv------- 213
O94589       149 SITTSGASISSSLPKSTSFSQLLRANSYIYRANVAFTGN---EPLQVGPTFFLRTYKIIDNHAkSGYISNDLv------- 218 Schizosaccharom...
EPY51322     149 SITTSGLSISSSLPKSTNFSQLFKANSFVLHSNLSFTGE---KPLQVGPTFRLRTYKIFESHAqSKFLNHDSi------- 218
XP_003718619 235 nsgnpvnnstdqvdspygfqegeRKPLWQEVVHKARVRLCRVPPDWKFdrergyiplplpqspnrdqrahssysytaknE 314
XP_001482576 212 -----------------akdddlLAISWKEEYSRALVRIISnn----------------------------------ksS 240
EGV63282     206 --------------------edeTPITWKEEFARAKVSIKSt------------------------------------gN 229
XP_002172067 220 -------------------------VSWKETYAKAKITVERkrh--------------------------------ansK 242
EPY49687     214 -------------------------VSWKEEYPKCSVYVKRfvs---------------------------------eeR 235
Q09721       216 -------------------------VRWQETFAKSDLYIKRvvs--------------------------------asqK 238 Schizosaccharom...
CCG84378     215 -------------------------ITWQETYARSILEVIRMPMEADIkhdesy-------------------ardhklN 250
XP_002172940 214 --------------------------LWKESMPLGHAYIRRvtsssq---------------------------kfeerM 240
O94589       219 --------------------------MWKEEMPVCIAKMFRMPPQRLksk---------------------------dtV 245 Schizosaccharom...
EPY51322     219 --------------------------IWQEDCSVCVAKVFRVPPQQShnk---------------------------nsL 245
XP_003718619 315 FSYHLEIIEDLDDGRLHDG------EGSFFDdipmagiresIPVHHLSKIFYTNTGRILNIgqelaPDNSPALLLKRDST 388
XP_001482576 241 FQYSLEIREDHNDGRYHDE------KPKVVV----------YDVKSIMRMFFSASGKLLKLe----SRSAPVLMFKLVDK 300
EGV63282     230 FSYDLNIIEDFDDDRYHEG------APKTKV----------VKVNDVRKIFFSRSGKLLRLd----NNDSAVLILKLDDE 289
XP_002172067 243 HAYCITLNEDLNDGRYHDEia---gMPSPTKgaflqgrkrtIPVSQVRKISYSLSGQLLDLe----QARTPVLAIQLSKP 315
EPY49687     236 FRYVLIIEEDLNDGRYHEEllgkdlSSSisgn------tieYPINCMSILCYTVSGKLLDIp----QSRSPVLAVQLMQT 305
Q09721       239 FSYVICIDEDLNDGRYHEEtv---gKPTsapvf---gkkleISLQRMSLLCYTVSGRLLNIs----QAKSPVLALQLTSI 308 Schizosaccharom...
CCG84378     251 YLYHFRVTENLDDGRYHEEler-stYKRDSHgfirg-asrdIPVHNIARLFFSASGRLLNId----EARTPVLVLKINHG 324
XP_002172940 241 LAYELCLDQSFDDGMYHDDd----eKALKIR----------IPLYNIQSLFYSLSGKILRLd----NVSSPVLLLKYIIQ 302
O94589       246 LAYALSLKQSFDDDRYHDEd----eTPVTKT----------ISLNDVRTLFFSLSGKLLRLd----DVQTPVLLLKYADD 307 Schizosaccharom...
EPY51322     246 LSYKLSLVQSFDDNRYHEEd----eVPMTKD----------ILLSTIQTLFYSVSGKLLRLd----EVTTPVILLKYKDN 307
XP_003718619 389 A 389
XP_001482576 301 D 301
EGV63282     290 Y 290
XP_002172067 316 S 316
EPY49687     306 F 306
Q09721       309 K 309 Schizosaccharomyces pombe 972h-
CCG84378     325 L 325
XP_002172940 303 S 303
O94589       308 E 308 Schizosaccharomyces pombe 972h-
EPY51322     308 P 308
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