Conserved Protein Domain Family
Adeno_E1B_19K
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pfam01691: Adeno_E1B_19K 
Adenovirus E1B 19K protein / small t-antigen
This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein. The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.
Links
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Statistics
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PSSM-Id: 279955
Aligned: 16 rows
Threshold Bit Score: 141.634
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4KSL0    27 MD----VWTILADFSKTRRLVEDSSDGCSGFWRHWFGTPLSRLVYTVKKDYNEEFENLFADCSGLLDSLNLGHQSLFQER 102 Human adenovirus 46
Q6WQ37     1 ME----AWECLEDFSAVRNLLEQSSNSTSWFWRFLWGSSQAKLVCRIKEDYKWEFEELLKSCGELFDSLNLGHQALLQEK 76  Human adenovirus 5
AGT76137   1 ME----VWAILEDLRQTRLLLENASDGVSGLWRFWFGGDLARLVFRIKQDYSVEFEKLLDDSPGLFEALNLGHQAHFKEK 76 
Q6QPB7     1 ME----IWTVLEDFHQTRQLLENSSEGVSYLWRFCFGGPLAKLVYRAKQDYKDQFEDILRECPGIFDSLNLGHQSHFNQS 76  Simian adenovirus 24
P06501     1 MD----LRTALQTFESTRRLLELCSNRTSFLWRWLFGTPLSRLVRQVKLEYEKDFERILDQCPGVFESLELGYHKVFEEK 76  Simian adenovirus 7
Q9WA49     1 MDy--qLLAKLTNVNYLRKVIVQGSQNCPWWKKI-FSDRFIKVVAEARRQYGQELIEIFVEGERGFGPEFLREGGLYEEA 77  Porcine adenovirus 3
Q994F2     3 LElslkLCKTLCDFKNLTRVVYYASDRPGWLSRYFFGGRLAQLVYKAKVDYHQTLTELFEDDQSFWCLLESGRTLGFEAK 82  Porcine adenovirus 5
Q9EEG2     1 MDlslqLCEQLSSLPQLRRVIYYATNRASWWSRTFFGGRLANLVYTIKVEEAESLQELFNEDEGFWQMFGSGRTLGYESK 80  Bovine adenovirus 2
P04886     1 MD----FLKPFCQYKVLKSVVVGASNQSSVVSRF-FGPKITKLIYSTKVSNRDQFLDSLPR--GYLDGLASGDFSKID-L 72  Tree shrew adenovir...
Q64843     1 MD----HLSVLLDLKLLRSIVAGASNRTGVWKRRLWLGRLTQLVHDTCVENESIFLNSLPGNEAFLRLLRSGYFEVFDVF 76  Bovine adenovirus 3

Q4KSL0   103 VLHSLDFSSPGRTTAGVAFVVFLVDKWSQDTQ---LSRGYILDFAAMHLWRAWirQRGqRILNY 163 Human adenovirus 46
Q6WQ37    77 VIKTLDFSTPGRAAAAVAFLSFIKDKWSEETH---LSGGYLLDFLAMHLWRAV--VRHkNRLLL 135 Human adenovirus 5
AGT76137  77 VLSVLDFSTPGRTAAAVAFLTFILDKWIRQTH---FSKGYVLDFIAAALWRTWkaRRMrTILDY 137
Q6QPB7    77 ILRALDFSTPGRTTAAVAFFAFILDKWSQETH---FSRDYRLDCLAVALWRTWrcQRLnAISGY 137 Simian adenovirus 24
P06501    77 IVKELDFSSPGRAVAAVAFASYLLDRWNTRTH---LSPGYQMDYISLNLWKFW--LRR-RVYNY 134 Simian adenovirus 7
Q9WA49    78 VLKELDFSTLGRTVASVALVCFIFEKLQKHSG---WTDEGILSLLVPPLCSLLe-----ARMMA 133 Porcine adenovirus 3
Q994F2    83 VVPWLDFSSTGRVVSSLSLLAYLVDHLDCHTD---FSKDYNLEVICAPVCCRLk-----TLVEI 138 Porcine adenovirus 5
Q9EEG2    81 IVPWLDFSTPGRATASLSLLAYIVDCLDKQSE---LSSDFILDAVCGPVCYKLk-----MLLSL 136 Bovine adenovirus 2
P04886    73 LVEQLDFTSAGRLTASLSLLVLVVEEWSARSC---VSFDILTELLLVPAWRKIi-----ATAWK 128 Tree shrew adenovirus 1
Q64843    77 VVPELHLDTPGRVVAALALLVFILNDLDANSAssgFDSGFLVDRLCVPLWLKAr-----AFKIT 135 Bovine adenovirus 3
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