Conserved Protein Domain Family
bHLH_TS_TWIST1
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cd11412: bHLH_TS_TWIST1 
basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar proteins
TWIST1, also termed Class A basic helix-loop-helix protein 38 (bHLHa38), or H-twist, is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B. In addition, TWIST1 is involved in cancer development and progression.
Links
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Statistics
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PSSM-Id: 381418
Aligned: 7 rows
Threshold Bit Score: 137.223
Created: 15-Sep-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #   # ### #    #                ####                             
Q15672        98 GSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMAS 174 human
NP_990070     86 GSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMAS 162 chicken
XP_005991332  65 GSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMAS 141 coelacanth
XP_007897889  62 GSPQSFEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLASRYIDFLYQVLQSDELDNKMSS 138 elephant shark
P13903        62 SSPQSFEELQSQRVMANVRERQRTQSLNEAFSSLRKIIPTLPSDKLSKIQTLKLASRYIDFLCQVLQSDELDSKMAS 138 African clawed frog
NP_001005956  59 SSTQSFEELQNQRVLANVRERQRTQSLNEAFASLRKIIPTLPSDKLSKIQTLKLASRYIDFLCQVLQSDEMDNKMSS 135 zebrafish
NP_001017820  65 NSPQSFEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLCQVLQSDELDSKMAS 141 zebrafish

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