Conserved Protein Domain Family
Glutenin_hmw
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pfam03157: Glutenin_hmw 
High molecular weight glutenin subunit
Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Links
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Statistics
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PSSM-Id: 367362
Aligned: 3 rows
Threshold Bit Score: 204.796
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P10388     1 MAKRLVLFVAVVVALVALTVAEGEASEQLQCERelqELQERELKACQQVMD------------------QQLRDISPECH 62  bread wheat
P10387     1 MAKRLVLFAAVVIALVALTTAEGEASRQLQCER---ELQESSLEACRQVVDqqlagrlpwstglqmrccQQLRDVSAKCR 77  bread wheat
EMS67071   1 MTKRLVLFAAVVVALVALTASEGEASGQLQCER---ELQEHSLKTCRQVVD------------------QQLRDVSPECQ 59 

P10388    63 PVVVSPVAGQYEqQIVVPPKGGSFYPGETTPPQQLQQRIFWGIPA-LLKRYYPSVTCPQQVSYYPGQASPQRPGQGQQP- 140 bread wheat
P10387    78 SVAVSQVARQYE-QTVVPPKGGSFYPGETTPLQQLQQGIFWGTSSqTVQGYYPGVTSPRQGSYYPGQASPQQPGQGQQPg 156 bread wheat
EMS67071  60 PVVVGPVARQYEqQVVVPPKGGSFYPGETTPPQQLQQSILWGIPA-LLRRYYLNVTSPQQVSYYPGQASSQRPGQGQQP- 137

P10388   141 -----GQGQQGYYPTSPQQPGQWQQPEQGQPRYYPTSPQQSGqlqqpaqg------------------------qqpgqg 191 bread wheat
P10387   157 kwqepGQGQQWYYPTSLQQPGQGQQIGKGQQGYYPTSLQQPG-------------------------------------- 198 bread wheat
EMS67071 138 -----GQGQQEYYLTSPQQSGQWQQPGQGQSGYYPTSPQQSGqeqpgyyptspwqpgqlqqptqgqqrqqpgqgqqlrqg 212

P10388   192 qQGQQpgqgqpGYYPTSSQlqpgqlqQPAQGQQGQQpgqaqqGQQPGQGQQPGQGQQGQQPGQGQQPGQGQQgqqlgqgq 271 bread wheat
P10387   199 -QGQQ------GYYPTSLQ-------HTGQRQQPVQ------GQQPEQGQQPGQWQQGYYPTSPQQLGQGQQ-------- 250 bread wheat
EMS67071 213 qQGQQsgqgqpRYYPTSSQqpg-qlqQLGQGQQGQQpergqqGQQSGQGQQLGQGQQGQQPGQKQQSGQGQQgyypi--- 288

P10388   272 qgyyPTSLQQSGQGQPGYYPTSLQQLGQGQSGYYPTSPqqpgqgqqpgqlqq---paqgqqpgqgqqgQQPGQGQQGQQP 348 bread wheat
P10387   251 ----PRQWQQSGQGQQGHYPTSLQQPGQGQQGHYLASQ------------------------------QQPGQGQQGHYP 296 bread wheat
EMS67071 289 spqqLGQGQQSGQGQLGYYPTSPQQSGQGQSGYYPTSAqqagqlqqsaqeqqlgqeqqdqqpgqgrqgQQSGQRQQDQQS 368

P10388   349 GQGQQPGQGQPGYYPTSPQQSGQGQPGYYPTSSQQPtqsqqpgq---------------gqqgqqvGQGQQAQQPG---Q 410 bread wheat
P10387   297 ASQQQPGQGQQGHYPASQQQPGQGQQGHYPASQQEP------------------------------GQGQQGQIPA---S 343 bread wheat
EMS67071 369 EQGQQPGQRQPGYYSTSPQQLGQGQPRYYPTSPQQPgqeqqprqlqqpeqgqqgqqpeqgqqgqqqGQGEQGQQPGqgqQ 448

P10388   411 GQQPGQGQPGYYPTSPQQSGQGQPGYYLTSPQQSGQGQQPGQlqqsaqgqkgqqPGQGQQPGQGQQGQQPGQGQQGQQPG 490 bread wheat
P10387   344 QQQPGQGQQGHYPASLQQPGQGQQGHYPTSLQQLGQGQQTGQ------------PGQKQQPGQGQQTGQGQQPEQEQQPG 411 bread wheat
EMS67071 449 GQQPGQGQPGYYPTSPQQSGQGQPGYYPTSPQQSGQLQQPAQgqqp------gqeqQGQQPGQGQQGQQPG---QGQQPG 519

P10388   491 QGQPGYYPTSPQQSGQGqqpgqwQQPGQGQPGYYPTSPLQPGQGQPGYDPTSPQQPGQGQqpgqlqqpaqgqqgqqlaqg 570 bread wheat
P10387   412 QGQQGYYPTSLQQPGQG------QQQGQGQQGYYPTSLQQPGQGQQGHYPASLQQPGQGQ-------------------- 465 bread wheat
EMS67071 520 QGQPGYYPTSPQQSGQGqqlgqwQQSGQGQPGHYLTSPLQPGQGQPGYYPTSPQQIGQGQqlgqlqqptqgqqgqq---- 595

P10388   571 qqgqqpaqvqqgqrpaqgqqgqqpgqgqqgqqlgqgqqgqqpgqgqqgqqpaqgqqgqqpgqgqqGQQPGQGQQGQQPGQ 650 bread wheat
P10387   466 -----------------------------------------------------------------PGQRQQPGQGQHPEQ 480 bread wheat
EMS67071 596 --------------------------------------------------sgqgqqgqqpgqgqqGQQPGQGQQGQQPGQ 625

P10388   651 GQQPGQGQPWYYPTSPQESGQGqqpgqwqqpgqgqpgyyltspLQLGQGQQGYYPTSLQQPGQGQQPgqwqqsGQGQHWY 730 bread wheat
P10387   481 GKQPGQGQQGYYPTSPQQPGQG---------------------QQLGQGQQGYYPTSPQQPGQGQQP------GQGQQGH 533 bread wheat
EMS67071 626 GQQPGQGQPGYYPTSLQQSGQGqqpgqwqqpgqgqpgyyptssLQPGQGQQGYYPTSQQQAGQGPQPgqwqqsGQGQQGY 705

P10388   731 YPTSP----------------------QLSGQGQRPGQWLQPGQGQQGYYPTSPQQPGQGQQLGQWLQPGQGQQgyypts 788 bread wheat
P10387   534 CPTSPqqs----------------gqaQQPGQGQQIGQVQQPGQGQQGYYPTSVQQPGQGQQSGQGQQSGQGHQ------ 591 bread wheat
EMS67071 706 YPTSPqqsgqgqqpgqwlqlgyyltspQQLGQGQQPRQWLQPRQGQQGYYPTSPQQSRQGQQL------GQVQQgyy--- 776

P10388   789 lqqTGQGQQSGQGQQGYYSSYHVSVEHQAASLKVAKAQQLAAQLPAMCRLEGGDALSASQ 848 bread wheat
P10387   592 ---PGQGQQSGQEQQGYDSPYHVSAEQQAASPMVAKAQQPATQLPTVCRMEGGDALSASQ 648 bread wheat
EMS67071 777 ---ptsPQQSGQGQQGYDSPYHVSAEHQAASLKVAKAQQLAAQLPAMCRLEGGDALLASQ 833
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