Conserved Protein Domain Family
7tmA_SWS1_opsin

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cd15076: 7tmA_SWS1_opsin 
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.
Statistics
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PSSM-Id: 320204
Aligned: 6 rows
Threshold Bit Score: 493.181
Created: 10-Nov-2008
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                #   #
P28684     33 YLQTAFMGIVFAVGTPLNAVVLWVTVRYKRlrqPLNYILVNISASGFVSCVLSVFVVFVASARgyFVFGkrvCELEAFVG 112 chicken
P03999     35 YLQAAFMGTVFLIGFPLNAMVLVATLRYKKlrqPLNYILVNVSFGGFLLCIFSVFPVFVASCNgyFVFGrhvCALEGFLG 114 human
P51473     33 TLQAIFMGMVFLIGTPLNFIVLLVTIKYKKlrqPLNYILVNITVGGFLMCIFSIFPVFVSSSQgyFFFGriaCSIDAFVG 112 African clawed frog
Q9W6A9     31 YLQAAFMGFVFIVGTPMNGIVLFVTMKYKKlrqPLNYILVNISLAGFIFDTFSVSQVFVCAARgyYFLGytlCAMEAAMG 110 zebrafish
ABS89281   33 FLQAAFMGFVLFVGTPLNAIVLFVTIKYKKlqqPLNYILVNISLAGFIFCFFGVFAVFIASCQgyFIFGktvCALEGFTG 112 Australian lungfish
AAR14684   33 YLQAAFMGFVFICGTPLNAIVLVVTIKYKKlrqPLNYILVNISAAGLVFCLFSISTVFVASMQgyFFLGptiCALEAFFG 112 pouched lamprey
Feature 1     #  ##                                                               ####        
P28684    113 THGGLVTGWSLAFLAFERYIVICKPfGNFRFsSRHALLVVVATWLIGVGVGLPPFFGWSRYMPEGLQCSCGPDWYTvgtk 192 chicken
P03999    115 TVAGLVTGWSLAFLAFERYIVICKPfGNFRFsSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTvgtk 194 human
P51473    113 TLTGLVTGWSLAFLAFERYIVICKPmGNFNFsSSHALAVVICTWIIGIVVSVPPFLGWSRYMPEGLQCSCGPDWYTvgtk 192 African clawed frog
Q9W6A9    111 SIAGLVTGWSLAVLAFERYVVICKPfGSFKFgQGQAVGAVVFTWIIGTACATPPFFGWSRYIPEGLGTACGPDWYTksee 190 zebrafish
ABS89281  113 SVAGLVTGWSLAILAFERYLVICKPiGNFRFgSKHSMIAVVAAWVIGVGVSIPPFFGWSRYIPEGLQCSCGPDWYTvgtk 192 Australian lungfish
AAR14684  113 SLAGLVTGWSLAFLAAERYIVICKPfGNFRFgSKHALVAVGLTWMLGLSVALPPFFGWSRYIPEGLQCSCGPDWYTvgtk 192 pouched lamprey
Feature 1              ##   #                                                    #   #        
P28684    193 yrSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRAVAAQQqesattQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMvn 272 chicken
P03999    195 yrSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQqesattQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMvn 274 human
P51473    193 yrSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRAVAAQQqesastQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMvt 272 African clawed frog
Q9W6A9    191 ynSESYTYFLLITCFMMPMTIIIFSYSQLLGALRAVAAQQaesestQKAEREVSRMVVVMVGSFVLCYAPYAVTAMYFan 270 zebrafish
ABS89281  193 ykSEYYTWFLFIFCFIIPLFIICFSYSQLLGALRAVAAQQqesattQKAEREVSRMIIVMVGSFCVCYVPYAALAMYMvn 272 Australian lungfish
AAR14684  193 ykSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRAVAAQQqesastQKAEREVSRMVIMMVASFCTCYVPYAALAVYMvt 272 pouched lamprey
Feature 1                   #   #                     
P28684    273 nrdhglDLRLVTIPAFFSKSACVYNPIIYCFMNkQFRACI 312 chicken
P03999    275 nrnhglDLRLVTIPSFFSKSACIYNPIIYCFMNkQFQACI 314 human
P51473    273 nrnhglDLRLVTIPAFFSKSSCVYNPIIYSFMNkQFRGCI 312 African clawed frog
Q9W6A9    271 sdepnkDYRLVAIPAFFSKSSCVYNPLIYAFMNkQFNACI 310 zebrafish
ABS89281  273 nrdhgiDLRLVTIPAFFSKSSFVYNPIIYCFMNkQFRACI 312 Australian lungfish
AAR14684  273 nrdhniDLRFVTVPAFFSKASCVYNPLIYSFMNkQFRACI 312 pouched lamprey

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