18266923 147 PPKAPA-----NGLRIYALGGISEIG-RNMTVFEYNN----RLLIVDCGVLFP------SS------GEPGVDLI----L 200 Corynebacterium glu... 1351578 1 ----------mAKIKFFALGGQDERG-KNCYVLEIDN----DVFIFNVGSLTP------TT------AVLGVKKI----I 49 Mycoplasma genitalium 20094694 1 -------------------MGIQRLA-HNSPYSHHRG----VKCSGDGGVLLR------PAds---wAGVLVDTGs---T 44 Methanopyrus kandle... 20094710 1 --------------------------------MLLRP------LDPWCGVVVDyg-----------dTRVFVDVT----- 26 Methanopyrus kandle... 2496428 1 ----------mAKINFFAFGGQDERG-KNCFVLEINN----DVFIFNVGSLTP------TT------AVLGVKKI----I 49 Mycoplasma pneumoniae 15678932 18 SPGTPHiltpgDYMDFRFYGGVDEIG-GNRIEVSCNG----DGIFLDFGKRFNienlyfDEflqprsFSGIADLIeleaL 92 Methanothermobacter... 15829176 1 ----------mPKLQFFALGGQDENG-KNCFVIEYSD----DIFIFNIGAKVP------IN------STYGVDTV----I 49 Mycoplasma pulmonis 14521766 11 TIGGTKihiedGNNGIFLDFGMNFAKySMYYEEFLRErtkrGIYDLWMLNLIPrl---nIYr----sDLIPNDLA----- 78 Pyrococcus abyssi 14590378 12 TIGGTKihieeNENGLFLDFGMNFARySLYYEEYLGErtsrGIYDLWKLNLIPkl---nIYr----rDLIPKDLA----- 79 Pyrococcus horikoshii 13358072 1 ----------mAKINFLSLGGQDERG-KSCFVLEVND----DIFIFNAGAKIP------TS------DVFGVNMI----V 49 Ureaplasma urealyticum
18266923 201 PDFGPIEDHLH------------RVDALVVTHGHEDHIG------------------------------------AIPWL 232 Corynebacterium glu... 1351578 50 PDFSWIQENQA------------RVKGIFIGNAITENLG------------------------------------SLEFL 81 Mycoplasma genitalium 20094694 45 IVAVDAGPNPWha---------eDTDYLLLTHAHLDHVA------------------------------------SLDRY 79 Methanopyrus kandle... 20094710 27 -DR--KGPY-Vk-----------RADAVIVTHPHRDHYGg------------------------------------VPRT 55 Methanopyrus kandle... 2496428 50 PDFSWIQENQA------------RIKGIFIGNPVTENIG------------------------------------SLEFL 81 Mycoplasma pneumoniae 15678932 93 PWIPGLYREDQvrylgmrfedepAVSGILLSHPHLDHAGclky-----------------------------irhDIPFY 143 Methanothermobacter... 15829176 50 PSFSYLKKNAK------------KIRGIFITDTKNSSFS------------------------------------ALPWI 81 Mycoplasma pulmonis 14521766 79 -QE--VSRYPRi-----------PVNAVLISHAHLDHVGnvalldekipivaspttl-vilkalrdtsrgnnlgmETPYY 143 Pyrococcus abyssi 14590378 80 -QE--VGQYPRp-----------QVNAVLISHAHLDHVGnitlldenisivgspmtitilkaindtstggnhfgvELPYY 145 Pyrococcus horikoshii 13358072 50 CDYSYLEKNAK------------RVKGIFIGTPTFNNVM------------------------------------GIKLL 81 Ureaplasma urealyticum
18266923 233 LKLRND--------IPIL--ASRFTLALIAAKCK-----EHRQRP---KLIEVNEQSN--EDR-------------GPFN 279 Corynebacterium glu... 1351578 82 FHTVGf--------FPIY--TSSIGASIIKSKINe---nKLNIARdklEIHELKPLET--IEI-------------SNHS 133 Mycoplasma genitalium 20094694 80 SRNG----------------AKVLCPGDVRDDLG--------LVDsavGVKKVKSMLY-------------------DVI 116 Methanopyrus kandle... 20094710 56 EFGELR--------------ADEVTAALLGME--------D-EAEplrSSFEAGL-----------------------LD 89 Methanopyrus kandle... 2496428 82 FHTVGf--------FPIY--TSTIGAVVIKTKIHe---nKLNIPHdelEIHELKPLET--VKI-------------GHHN 133 Mycoplasma pneumoniae 15678932 144 MTEESfl------iLKAIedTSTLSSDLLHYKPKfhfkeKKRKTGntsHMRDKNIKIErpIKLlepyk----aedlGEFE 213 Methanothermobacter... 15829176 82 LMQIPG--------LKIY--TSPFSKVNVLDRVS-----KYKIGHndyEIITISKDISf-----------------GDIT 129 Mycoplasma pulmonis 14521766 144 TPRKRTegnpplveANTG--KYYPTRDLILTDKFs---eEVRRFMrwrAEVELANKNN--IKRiklgkvqnleesyLGFE 216 Pyrococcus abyssi 14590378 146 KVRKIKdpegyiieADRK--ADYPSRKVVLTEHVq----SLHEFLfyrPGQESPK-----AKKiipnevktleeedLGFE 214 Pyrococcus horikoshii 13358072 82 LGQVGy-------kIPIY--TSPIGAIVIKKIFEq----KVNNKKiepNIIELDPISD--KKI-------------GSIY 133 Ureaplasma urealyticum
18266923 280 IRFWAVNHSIPDCLGLAIKTPAGLVIHTGDIKLDQTPPDGR--PTDLPALSRFGDEGVDLMLCDSTNAT--TPGVSGSEA 355 Corynebacterium glu... 1351578 134 ITPFKVSSSLPSSFGFALNTDNGYIVFIDDFIVLNDKNIAF--ENQLNQIIPKLSDNTLLLITGVGLVGr-NSGFTTPKH 210 Mycoplasma genitalium 20094694 117 VHPIPVEHTCS-AYAYVLDLEECNVLVTGDWHVGPRTIDGEikPLWKAVREVVGGEGVDVIVSEATRALvdAPELGGNER 195 Methanopyrus kandle... 20094710 90 VRTYPVNHMCPKAHAVLLSGDAR-VLITGDWCALG---E-----HPP-LWELVDDE-VDAIVTECTRAAsvHPDDPEAAE 158 Methanopyrus kandle... 2496428 134 ITPFKVSSSIPSSFGFALHTDDGYIVYVDDFIVLNDKNIAF--ENQLNQIIPQVANKTLLLITGVGLVGr-NTGFTTPKH 210 Mycoplasma pneumoniae 15678932 214 ITQAPVDHSVPGSCAYLIESEEA-IVYTGDIRFRGRRDQES---RKFVKKARKFSP--TVMITEGTRID---QDNSTFEE 284 Methanothermobacter... 15829176 130 IKPIQVFGSVPGTLGFDVQSPMGSVVFLLNFILGENGFFGK---TDLLAIKKQVNNNLLALVMDSGKSK--NPGFAKDKI 204 Mycoplasma pulmonis 14521766 217 VRAYPVDHSIYGATAYIIEGDVS-VAYTGDFRLHGKNGN-----LTR-KFIKAAKN-ASILITEGTRVSrkNDDFNVSEK 288 Pyrococcus abyssi 14590378 215 VKAFNVDHSIYGATAYIIEGDVS-LAYTGDFRLHGRKGD-----ETR-KFIKAAKS-SSILITEGTRVGr-DEHGNVSEQ 285 Pyrococcus horikoshii 13358072 134 VTSFKVSNSMPHSYGFVLKTSDGAIVYVDEFIISNDKNKTF--DSQINLLNNITKNNTLALIVGMGQAG--NPYFTAPNH 209 Ureaplasma urealyticum
18266923 356 DVAPTLKRLVGDA--KQRVILASFASNVYRVQAAVDAAVASNRKVAFNGRSMIRNMEIAEKLGYLKAPRG-TIISMDD-- 430 Corynebacterium glu... 1351578 211 KSLEQLNRIITPA--KGRIFVACYDSNAYSVMTLAQIARMQNRPFIIYSQSFVHLFNTIVRQKLFNNTHL-NTISIEE-- 285 Mycoplasma genitalium 20094694 196 VFEYALSLHDPRD-----VLAFLQPTDLEIIDTAFRVASDLGLDVVVDSETDRKLKFLERRGDVEWEYD----------- 259 Methanopyrus kandle... 20094710 159 YRIQRLLELHRED--R--TVLLLTHVN----------------PLIDVASEVEILHVLEGDP--VDEAVKaGAHEG---- 212 Methanopyrus kandle... 2496428 211 KSLEQLNRIIASA--KGRVFAACYDSNAYSVMTLAQIARMQNRPFVIYSHSFVHLFNAIVRQKLFNNTHL-NTISIEE-- 285 Mycoplasma pneumoniae 15678932 285 DIERRTSDIAVNH--RGLVIINYPIRDLDRFLTFYRAAENSDRTLAVSLKQAYIIKLFEGLGYPWLRDLA-VYIPRRN-- 359 Methanothermobacter... 15829176 205 HLPKSVEQVFENAkdNERIIVGAYDEEIGSLNYILDLAKKYNRPIITYGKSYGKQIFLIKKINPKFKTS--EFLNYKK-- 280 Mycoplasma pulmonis 14521766 289 EVYENALRIVEEA--KGLVIADFSLRNFERLESFKRIAEKTGRELVITTKEAYYLHALKTAG-EADHLREvKIYEDSKtk 365 Pyrococcus abyssi 14590378 286 EVYENALKIVEEA--KGLVIADFSPRNFERLEIFKKIAENTGRELVITAKDAYFLHALQLVD-NVNRLKDlRIYGNLKat 362 Pyrococcus horikoshii 13358072 210 KNKAFYEAALQNT--KNRLIVGCYSNDAYSIFTLATIAKQQNRPFIVYSNNFINTFIGVLKLKLFNSK---NLISLP--- 281 Ureaplasma urealyticum
18266923 431 -----------------ASRMAPH---KVMLITTGTQGEPMAALSRMARREHRQ-I--TVRDGDLIILSSSLVPGNEEAV 487 Corynebacterium glu... 1351578 286 -----------------INNSTNS-----IVVLTSPPDKLYAKLFKIGMNEDER-I--RYRKSDTFIFMTPKVAGYEEIE 340 Mycoplasma genitalium 20094694 260 --------------------------------VADEPLVRSLYLTVSWEKAR---------ELAEAGLVEAVVGN--WAT 296 Methanopyrus kandle... 20094710 213 -------------------------------ADLEVVSRPEYPLVTSSVGTVEG------LSKRPHVLITER-----WFL 250 Methanopyrus kandle... 2496428 286 -----------------INNSTNA-----IVVLTAPPDKLYAKLFKIGTNEDER-V--RYRKTDSFIFMIPRIAGYEELE 340 Mycoplasma pneumoniae 15678932 360 -----------------WGLIAED-----AFVCFDGEWIPAADLPEEYMEQDYRgWerAFLELDNTITCRDLREE-PEEY 416 Methanothermobacter... 15829176 281 -----------------ANFVPN-----ALILVTGTVERLYQRFLRIAKNEDVYlN---LKSSDNVIFIAPPVNGIEVIA 335 Mycoplasma pulmonis 14521766 366 pekwekw-ilskynelkVTPEEITreqENYILCFSFYDMPKLLDIMPSGGVYIYsS--SEAFTEEQVFSFLRLWN--WLQ 440 Pyrococcus abyssi 14590378 363 qdkwesivvwgnyaeqyISPFEIRknqENYILCFSFYDMPHLLDIMPDGGTYIYsS--SEAFGEEQVFSFLRLWN--WLQ 438 Pyrococcus horikoshii 13358072 282 -----------------VSEINNSk--NAIIVVIENQDTLFSKLNKILHNEDKY-V--NLSSDDQLILGVVITPGFEMLA 339 Ureaplasma urealyticum
18266923 488 FGVINML-AQIGATVVTGRD-AKVHTSGHGYSGELLFLYNAARPKNAMPVHGEWRHLRANKELAISTGVNRD---NVVLA 562 Corynebacterium glu... 1351578 341 AQILDDI-ARNEVSYYNLGR---EILSIQASDEDMKFLVSSLKPKYIIPTGGLYRDFINFTMVLKQAGAEQN---QILIL 413 Mycoplasma genitalium 20094694 297 VHHLRRR---VGVKYAYVIP-----RSGHASRPEITRLITELEPSCLVFRHRSGDATRLERYYSRFVDEVR-----VWVG 363 Methanopyrus kandle... 20094710 251 YRDREG--RLRRLLDAVP-YpYIVSGTGHASAAELVRLVEELEPEYLVLRHGS-PDGVRALRKRLAGAGLDVrveAWIGR 326 Methanopyrus kandle... 2496428 341 AQILDDV-ARNEVSYYNLGR---EILSINASDEDMKFLVTSLKPKYIIPTSGLYRDFINFTMVMKQAGVEQS---QVLIP 413 Mycoplasma pneumoniae 15678932 417 LFQCDYFeFKEFIDIKPEG---AAYIKSKTEPFNEEMEIDAERESNWLRHFGIYQYRRFHSSGHAGRSDLLG---MIRDI 490 Methanothermobacter... 15829176 336 AHTLDQV-TKVSPKILDVT--EEEYYRHRPASKDIYQTIDVLRPKYYIPVQGLYRYLVDAAALVRPLGYNTK---NTLVL 409 Mycoplasma pulmonis 14521766 441 YFGFEVH-GFKVDEHGRPIFeKGFHASGHISKDELVKVIEEVDPDYIVPVHTENPEWFREV---WEDK--------AIIL 508 Pyrococcus abyssi 14590378 439 YFGFEVH-GFRVDKYGKPIFeKGFHASGHISREELRKVIDEIDPDYVIPVHTEKPELFKWA---FGER--------VILL 506 Pyrococcus horikoshii 13358072 340 AELSDEV-GRLDIPYKALP---KTVLPMTQSDEDLKHLINFLQPKFLIPINGLYKTEVKFSSTVTTSWIKSD---QIISV 412 Ureaplasma urealyticum
18266923 563 QNGVVVDMVNGRAQVVG--QIPVGNLYVDGVTMGDIDADILADRTSLGEGGLISITAVIDNRTGRLLERPTVQTSGFSE- 639 Corynebacterium glu... 1351578 414 FNGEVLTIENKKLDSKKn-ELKLNPKCVDSAGLQEIGASIMFERDQMSESGVVIIIIYFDQKKSEFLNEITYSFLGVSLd 492 Mycoplasma genitalium 20094694 364 RGCRDESLELPP-------------------------------------------------------------------- 375 Methanopyrus kandle... 20094710 327 RGGKLELP------------------------------------------------------------------------ 334 Methanopyrus kandle... 2496428 414 FNGEVLAINHKQIDNKKr-ELKLNPKCVDSAGLQEIGASIMFERDQMSEAGVVTIIIYYDSKKSEFLNEITYSFLGVSLd 492 Mycoplasma pneumoniae 15678932 491 EPESIYPIHTRNREEFLi-FEDESIRVLDPPQ------------------------------------------------ 521 Methanothermobacter... 15829176 410 QNGKIAEFDGGKLISHNkkIKQVGDDIIDGFGLGDVSHEVIREREKMASNGVVLISACIN-KFKQIKGKIEIKYLGLVSi 488 Mycoplasma pulmonis 14521766 509 RNGDSWEI------------------------------------------------------------------------ 516 Pyrococcus abyssi 14590378 507 KNGESWEI------------------------------------------------------------------------ 514 Pyrococcus horikoshii 13358072 413 SNGELFTIEDKVLNPKPq-IIELEDKYISSFDALDVGANILFERSQMGENGVINLIVIFDKQFQKLFNYVEFDYCGVVNn 491 Ureaplasma urealyticum
18266923 640 DAK-----SMMGEVTeLSETTMNDLAAEGe----NDPYRMVQQLRRKLSRFVEQKWKRQPVIMPTVI 697 Corynebacterium glutamicum 1351578 493 VPEkdklkTKMEELIkKQINDIKDFTTIKkrigkEISKELKVSIKRAVMNLFTKMTSKAPLILSTII 559 Mycoplasma genitalium 20094694 ------------------------------------------------------------------- Methanopyrus kandleri AV19 20094710 ------------------------------------------------------------------- Methanopyrus kandleri AV19 2496428 493 SNNqvklkTKMEELIrKQINDIKDFTTIKrrlgkDTSKELKVSIKRAVMNLFTKMTAKAPLILSTII 559 Mycoplasma pneumoniae 15678932 ------------------------------------------------------------------- Methanothermobacter thermautotro... 15829176 489 ADRd----EINDFVRsIVVNNFYDEENSS-------LKVIQEKIRKQVRKKLYKKIEKEPIVVVVFY 544 Mycoplasma pulmonis 14521766 ------------------------------------------------------------------- Pyrococcus abyssi 14590378 ------------------------------------------------------------------- Pyrococcus horikoshii 13358072 492 DAQi---kEIEETFKkRMGECLVYDERKR-----LILKDTKANLKRLLTKLFEKKFNKRPLVLPTVV 550 Ureaplasma urealyticum
Jiyao W et al.(2023). "The conserved domain database in 2023.",