Conserved Protein Domain Family
ANIS5_cation-bd
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pfam02520: ANIS5_cation-bd 
SXP/RAL-2 family protein Ani s 5-like, metal-binding domain
This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.
Links
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Statistics
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PSSM-Id: 396877
Aligned: 72 rows
Threshold Bit Score: 52.5834
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003096994  63 SRQEFFSII-QNDKLSKSEIWERVEQWAEKQseYVKTDIMEFHQR-LSQHVDNSKMRVERIIKNLP----EALRRLSEIV 136 
XP_003089397  40 QRSSFFAIS-KNPGFSFQQKDDKLEKWAEDN--KLSEPYAEFRRN-LSNHKEQVSKNVSAAIDRLA----EAKAEVDKVD 111 
CAP26208     178 QRSSFFGIS-KNPGISFQQKEDKLVKWAEAN--NLTEQYAEFYKN-LQLHKEQRSKNISAVIERLA----EAKVEVDKVN 249 
EFP04451     102 ARKEFFDIV-SNEQLSQDQQNEQLTIWAKAF--NVTDEFNTWAKQ-VQEQKEAVSQNVQAVVANIS----TVYNQLEEIL 173 
7_pfamImport   1 ARKEFFDII-HNDQLSMNEQNAQLTIWAKAL--NVTQEFNQWIQK-VQKQKDSVSHNTQTVVANIS----TVYTTLENIL 72  
CAP33522      53 ARKEFFDIV-SNEGLSQDEQSAQLTIWAKAF--NVTDEFNAWTKQ-VQAQKDAITQNVQAVVANIS----TVYNQLEEIL 124 
EGT44867     163 EQDKFYEIV-QHPSWSGAEKNRRIEEFMKTMsdERQSMYSNYRRDvVSKEMEEKRQRVDRAVSTMTkeavDEFQRVVRIM 241 
XP_001900036  39 VVKQFFDLLkADESKTDPQTEADIEAFIRRLggDYQTRFEQFKQE-IKKEKAQYEKIHQAALLKFSpaarEADAKMSAIA 117 
6_pfamImport   2 QLQSFQGVIqNNGHLTDAALDAKVQQWVNQQggNVAADWAEFQKF-IKGQQSQAEAAHQAAIASFSpaakKADSELTAIS 80  
Q23683        34 QLKSFQQMIqSNGHLTETAMGAKIQEWVDQQggKVAADWKDFQEF-IKGQQGKSEAAHQTAISSFSpeakKADAELTAIS 112  Caenorhabditis...

XP_003096994 137 QDIDITRVQEKNRIANLYTSLDDDvSKTLQWIVHLV 172 
XP_003089397 112 ADFSLTKIQRDDKIEELKQKYPQE-IPTLFYMRSLF 146 
CAP26208     250 ADLSLTKTQRDEKIDELKKTYPQE-IPTIFHINSLF 284 
EFP04451     174 SNTNLTRRDQHDQIRKLGVTYPRK-SFKIFQEVRtl 208 
7_pfamImport  73 SNTNLSRREQQEQIRNLSSTSPKE-MDALFFIARN- 106 
CAP33522     125 SNTNLTRRDQHDQIRKLGTTFPRE-VRALFFIARNY 159 
EGT44867     242 HDPSQTEPEKLKKIEEIYSKLPDS-------IRKEF 270 
XP_001900036 118 DSTQLTNHQKTEQIKAIMDSLSEA-------VRKEI 146 
6_pfamImport  81 NDQSLSVQAKGQKIQSYLQALPAN-------VRAEL 109 
Q23683       113 NDASLSIKAKGDKIQAYLTTLPAN-------VKAEL 141  Caenorhabditis elegans
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