Conserved Protein Domain Family
FH_FOXD4-like
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cd20048: FH_FOXD4-like 
Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins
FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410822
Aligned: 11 rows
Threshold Bit Score: 188.174
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Download Cn3D
 
DNA binding
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based structure evidence that Rattus norvegicus FOXD3 (2HDC) binds DNA through its Forkhead domain.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ######                ##                 ## ### ###  #     ###### # ######     
Q12950       104 KPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGRPGKGNYWSLDPA 183 human
Q9NU39       107 KPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGTYWSLDPA 186 human
Q3SYB3       108 KPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPA 187 human
Q6VB84       108 KPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPA 187 human
Q8WXT5       108 KPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPA 187 human
Q5VV16       108 KPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRrKFPAWQNSIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPA 187 human
Q02361        85 KPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKdKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPL 164 fruit fly
Q5WM45        97 KPPYSYIALITMAILQSPHKKLTLSGICDFISSKFPYYKdKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPA 176 tropical clawed...
XP_007884665  65 KPPYSYIALITMAIMQSPRKRLTLSGICQFIRSHFAYYQeRVPAWQNSIRHNLSLNDCFLKVPREAGHLGKGNYWTLDPG 144 elephant shark
VDD75621      79 KPPYSYIALITMAIMQSPNQRLTLSGICNFIMAKFPYYKeRFPTWQNSIRHNLSLNDCFVKVPREPGNTGKGNYWTLDPN 158 Mesocestoides c...
XP_019333538  29 KPPYSYIALIAMAILQSPQQRLTLSGICAFIRARFAYYGaRFPAWQNSIRHNLSLNDCFVKVPREPGRPGKGSYWRLDPA 108 American alligator

Feature 1                   #####
Q12950       184 SQDMFDNGSFLRRRKR 199 human
Q9NU39       187 SQDMFDNGSFLRRRKR 202 human
Q3SYB3       188 SQDMFDNGSFLRRRKR 203 human
Q6VB84       188 SQDMFDNGSFLRRRKR 203 human
Q8WXT5       188 SQDMFDNGSFLRRRKR 203 human
Q5VV16       188 SQDMFDNGSFLRRRKR 203 human
Q02361       165 AEDMFDNGSFLRRRKR 180 fruit fly
Q5WM45       177 SEDMFDNGSFLRRRKR 192 tropical clawed frog
XP_007884665 145 STDMFKDGSFLRRRKR 160 elephant shark
VDD75621     159 SQDMFEHGSFLRRKKR 174 Mesocestoides corti
XP_019333538 109 CRGMFDHGSFLRRRKR 124 American alligator

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