Conserved Protein Domain Family
Tcf25

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pfam04910: Tcf25 
Transcriptional repressor TCF25
Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions.
Statistics
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PSSM-Id: 461476
Aligned: 80 rows
Threshold Bit Score: 211.665
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8I434        304 FKIE---KNKLYLDAENLFYLLLDTHDI-QAMNELVKKYPFHVDTLLVLAEYY-NETRNYEVANKFIKMSILLLQNIFHI 378  Plasmodium fa...
Q38EB2        296 YLDV---SAPESQRADADLAECEKLVDAvDGLMGCLGKTPYHIPTLIVVSNVFeTMG-NVPRALEVIDLALYHLGVLLQ- 370  Trypanosoma b...
Q4CST5        296 YLDD---SSAETRRAEAALAVCGSMHAGvEGIMTCLAAAPYHIPTLIIASNLFeTMG-NIPRAQEAIDIALYHVGVLLS- 370  Trypanosoma c...
EER34832      300 FQFSkinDIKERVANTRFYASVVMTPDP-DSLMQLLQQYPYHVETLLQVAMVLlRQGDNKATSNALIERALFAFDRSFHK 378 
EMG47197      296 FQFSqtnNIKERVANTRFYASVVMTPDP-DSLMQLLQQYPYHVETLLQVAMVLlRQGDNKSTSNALVERALFAFDRSFHK 374 
CCE44816      292 FKFNkvtDTRSRIANTRFYASTVLTPDP-ESLMQLLQSNPYHQETLLQVAMVLlRQGDNKATSNALIERALFTFDRSFHK 370 
XP_001525925  388 FRFNkvhDIKNRVANTKFYAATVLTPDP-ESLFQLLQVSPYHHETLLQVAMVLlRQGDNKATSNALIERSLFTFDRSFHR 466 
EEQ40478      294 FKFNkinSVTERMANSKFYASVVMTPDP-ESLMQLLQQHPYHVETLLQVAMVMlRQGNNKATSFALVEKCLFVFDRSFDK 372 
CCE81218      355 FKFSkvsTIQERLANTKFYASVVMMADP-DSLIQLLQHYPYHAETLLQVSMIMlRQGGDKSVANALIEKCLFVFDRSFNM 433 
Q7RGJ4        246 FKIE---KEKLYLEAENLFYLLLDTHDI-QSMNDLIKKYPFHIDTILILAEYY-NETNNYEVANQYIKMALLLLQNIFHM 320  Plasmodium yo...
Q8I434        379 NFhpnflNKNF-NIFINPYIYDNKCLFKSLYMHMLSLENEACTITSLEIAKLLCKIDLANDLCSILLRIDNIILKCNLYD 457  Plasmodium fa...
Q38EB2        371 SFplrqtARQRc---VPFSIPSNKQLFQVLRCGIHHALRKAAVRTAWETCKLLYSLDPK-DPFGSLFLLDYLALRSKGWA 446  Trypanosoma b...
Q4CST5        371 RFpvrqtVRRRc---LPFGVTPNRQLFQVLRCGVHQALRKAATRTAWEIAKLIYSLDDT-DPLGMLLQLDYLALRAKQWA 446  Trypanosoma c...
EER34832      379 NFhellsQASNgLVRLPYERFMNRQFHLYLFRYIVALGERSTFYTALTYCKLLLSLNPAEDPLGVRYFIDFYAIMSEEFK 458 
EMG47197      375 NFhellcQASTgLIRLPYERFMNRQFYLCLFRYIVALGERSTFFTALSYCKLLLSLNPAEDPLGVRYFIDFYAIMSEELN 454 
CCE44816      371 NFhelvmSAQNgLIRLPYEFFSNRQFYLNLFRYIVSLGERSLFETALTFCKFLLSLSPAEDPLGTRYFIDFYCIMSEEFE 450 
XP_001525925  467 VFhellsSAQNgLIRLPYEFFSNRQFYLNLFRYIVSLGERSLFSTAMSYCKLLLSLSPAEDPMGVRYFMDFYAIMSDNFD 546 
EEQ40478      373 TFhemlcEGRTgLLRLPYESFMNRQFYLCLFRMISALGERNTFYTALNYCKFMLSLSPAEDPLGVRFFIDHYAILSEEYQ 452 
CCE81218      434 KFhellsNGKLsLIRLPYECFLNRQFYLCLFRYITSLGERSMFSTAFAYCKFLLSLSPAEDPLGVRYFLDFYAMMNDDYH 513 
Q7RGJ4        321 NFnidyiNNNH-KIYVNPQLYDNKVLFKTLYMHMQSLEYEGCTITSLEIAKLLCKIDLCNDLCGILLRIDGIMLKGNVFE 399  Plasmodium yo...
Q8I434        458 FLLYFSFNFIIQNiqsvippntynqivtslmnqqnsitpnhiesnllknnmdninninteiqehninktnvesnkhdhni 537  Plasmodium fa...
Q38EB2        447 WLVHVYYLLIREScripnsrtlpptaec---------------------------------------------------- 474  Trypanosoma b...
Q4CST5        447 WLVQVSFIVARELerhaegkvddt-------------------------------------------------------- 470  Trypanosoma c...
EER34832      459 YLVQFTES------------------------------------------------------------------------ 466 
EMG47197      455 YLIQFSES------------------------------------------------------------------------ 462 
CCE44816      451 YLIQLSKS------------------------------------------------------------------------ 458 
XP_001525925  547 YLIKFRKS------------------------------------------------------------------------ 554 
EEQ40478      453 YLIDLVDS------------------------------------------------------------------------ 460 
CCE81218      514 FLTGFCES------------------------------------------------------------------------ 521 
Q7RGJ4        400 FLVFFSFNFILQNihyvmplsrtneiisdfffnendikngenciteklnpneeishnnipttnqstneisktqenil--- 476  Plasmodium yo...
Q8I434        538 ssnnqmstnqnqsstqknknsynsnkeqdthtsncnenhilknnltsssqhcdifineqnkqsiimnkqnnlyifNNYEL 617  Plasmodium fa...
Q38EB2        475 ------------------------------------------------------------vnsgcsnlsnhelalSLSTL 494  Trypanosoma b...
Q4CST5        471 ----------------------------------------------------------------ndawsnrklalALSTL 486  Trypanosoma c...
EER34832      467 ---------------------------------------------------------------------------PLVQT 471 
EMG47197      463 ---------------------------------------------------------------------------PLVTP 467 
CCE44816      459 ---------------------------------------------------------------------------PLVTC 463 
XP_001525925  555 ---------------------------------------------------------------------------PLVTC 559 
EEQ40478      461 ---------------------------------------------------------------------------PLTST 465 
CCE81218      522 ---------------------------------------------------------------------------PLVTT 526 
Q7RGJ4        477 ------------kmeckenisslkrqdgdifddekiiyeqfsqnndftkklpeqdrnndkldylqnthtkkkydfQNYEI 544  Plasmodium yo...
Q8I434        618 rlhfilPNFAFAIPMSLYLKmNThlnlddiklikkddiihsfsyeeckyliphfnirficyksnhqinytgnqtcqnnih 697  Plasmodium fa...
Q38EB2        495 ------PGFFFSAALAKLFLeREeathtqkggkls-----------------------------------------rvir 527  Trypanosoma b...
Q4CST5        487 ------PGFFFSTALAKYFLeREeatsavsgvsnkgk-------------------------------------sskvlr 523  Trypanosoma c...
EER34832      472 ytkwltPGLAFSTVLAYL-------------------------------------------------------------- 489 
EMG47197      468 ysqwytPGIAFSTVLAHL-------------------------------------------------------------- 485 
CCE44816      464 ytrwysPGIAFSTVIAYL-------------------------------------------------------------- 481 
XP_001525925  560 ytrwytPGIAFSTALAYL-------------------------------------------------------------- 577 
EEQ40478      466 ysqwftPGLAFSKVLALL-------------------------------------------------------------- 483 
CCE81218      527 ykkwltPGLAFSCALAHF-------------------------------------------------------------- 544 
Q7RGJ4        545 rlhfilPNFAFSIPLCLYLKnNTnvnyneineikkndilssfsyeeckf------------liphfninfncywgnnnvs 612  Plasmodium yo...
Q8I434        698 dtkqnqdNnqNYSLSFCAHLFLIRALLQYPCFLKTFLNYNNFKATkiVKQTiydylfqdilaappfsNTQQL-NREEYEI 776  Plasmodium fa...
Q38EB2        528 dispaelH--AFHDTPPSGVMLADAIGRFPSAAVLLVEKVGSQAQ--PSVApaawk-------evvkGHMNNnGGQRLRV 596  Trypanosoma b...
Q4CST5        524 eltptqlH--AFRNTPPASVMLAHAISRFPSAAVLIVEKIGGQSV--VSSVpvswq-------divkAHELNtEENSLHV 592  Trypanosoma c...
EER34832      490 ----------KLNQTDKAQAALEKAFEHHPYTAFKLYQLIGLGDN--LAIS-----------------ESSFnVTTEISI 540 
EMG47197      486 ----------KLDQKEKAREALVRAFKAQPYAAFRLYQQIGLGSN--LTVD-----------------EKSFkLTTEVKL 536 
CCE44816      482 ----------ELNKVDDAEREMQKAFEAYPYVAYRLLTDVALSSV--AGVK-----------------ESDFeVTHEVAV 532 
XP_001525925  578 ----------KLEQTELAIEELRNAVKEHPYTAYKILTEICISNN--VHLK-----------------DSDFdVDAETLI 628 
EEQ40478      484 ----------YLGQTDKARAALKDAFSAHNYCSLQLLAVVGLATK--PPVK-----------------VSEVhKDDSIIL 534 
CCE81218      545 ----------NLDKIELAKEKLAVAFENFPYVSFKLLEQVCKVDT--LPVS-----------------EKDLeITDEDRL 595 
Q7RGJ4        613 nlcdkknI--SYSLSYSSHLFLIRALLFYPDFVQIFVKYNNFNTSkiVKNTiydisfkhilshppfsDNTLFsNKEEYEI 690  Plasmodium yo...
Q8I434        777 VQKivsCFLEKNNIYYKSEKVITWLHVCSsfiHEMYKD------------------------------------------ 814  Plasmodium fa...
Q38EB2        597 AT----LWVARNAEMWNAAEPSGFLRRVIteeSGVYLKslsv-------------------------------------- 634  Trypanosoma b...
Q4CST5        593 AS----MWVARNAEIWKAADPCAFLRRVItedDGLWLKshrtdidanl-------------------------------- 636  Trypanosoma c...
EER34832      541 ATE---TYLVRCGIMWNDQSHRQFLHDAL---QKLFDGwkpdksksitsslf---------------------------- 586 
EMG47197      537 ATE---TYMVRCGVMWTEHAHRQFLHDEI---QQLFADwkpqqaktisstlf---------------------------- 582 
CCE44816      533 CAE---TYMVRAKLLW--QKHLDFLSTNL---EKLFKTkhkpvrgsffg------------------------------- 573 
XP_001525925  629 SAE---TYLVRAKILW--ASDLEFLTINL---ESNLAEnrqkssgwffgssgsssgsgsgsgsspgsnsggngsitntlk 700 
EEQ40478      535 ASE---TYLVRASILWKEQNHRQFLHDEL---MKLFKTqsegsksswlg------------------------------- 577 
CCE81218      596 AGE---SYLVRAKFLWNNQAKLSFLEEEL---ISLFKSksskranysglssvy--------------------------- 642 
Q7RGJ4        691 VQKiilAYLEKNNIYYKSEKMITWVHVCSafiHEMYKD------------------------------------------ 728  Plasmodium yo...
Q8I434        815 --------------------KKvsqeidevrkeycqkialldINKYKHVRVGEFK---SHNYLLPDflMEkNRSYTPNVT 871  Plasmodium fa...
Q38EB2        635 -----------------saaNPca----------------dvPTPWEHEMLREEDlmgTVMAAIPAh------------l 669  Trypanosoma b...
Q4CST5        637 ----------sasaavvtaeSPh------------------lPTPWKHASLTEEDilcQTLTTIPAh------------l 676  Trypanosoma c...
EER34832      587 ------gllgfsggdtvnqeVP--------------------FNLLRFAILSGEN---KIIAKLPQklLS-RNDLFEYDL 636 
EMG47197      583 ------gllglsekdlssqeVP--------------------FNLVRFAILSGEN---KIMAKLPKklWS-RDDLFEYDL 632 
CCE44816      574 ----------flnakeipkeVP--------------------FNLIRFAILSGEN---KIMAKLPKsvWN-RDDLLEFDV 619 
XP_001525925  701 nffgrvglegststlaknkdVP--------------------FNLVRFAILSGEN---KIMGKLPQkiWN-RDDLHEYDV 756 
EEQ40478      578 ----------kwfntkestdIP--------------------INLIRFAILSGEN---KVLAKIPEkiFS-RSDILEYDV 623 
CCE81218      643 ------slffgskpdtpsseLP--------------------LNLIRFAVLSGEN---TMMARIPKkvWN-TQELLEYDI 692 
Q7RGJ4        729 --------------------ELvakeldearkqwhrriplldINKYKGIRVSEFK---SRNYLLPDfmMEkTVSHPA--P 783  Plasmodium yo...
Q8I434        872 NRA 874  Plasmodium falciparum 3D7
Q38EB2        670 LDP 672  Trypanosoma brucei
Q4CST5        677 LDP 679  Trypanosoma cruzi
EER34832      637 VPP 639 
EMG47197      633 LPP 635 
CCE44816      620 LPP 622 
XP_001525925  757 LPP 759 
EEQ40478      624 IPP 626 
CCE81218      693 LPP 695 
Q7RGJ4        784 VPN 786  Plasmodium yoelii yoelii
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