Conserved Protein Domain Family
NTP-PPase_u3
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cd11540: NTP-PPase_u3 
Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea
This family corresponds to a group of uncharacterized hypothetical proteins from bacteria and archaea, showing a high sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, members in this family consist of a single MazG-like domain that contains a well conserved divalent ion-binding motif EXX[E/D].
Links
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Statistics
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PSSM-Id: 212147
Aligned: 27 rows
Threshold Bit Score: 70.7334
Created: 29-Aug-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative metal
Feature 1: putative metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:E E X DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on sequence similarity to other superfamily members.
  • Comment:Most members of the NTP-PPase superfamily contain the well-conserved divalent ion-binding motif, EEED.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #  #                                 #  #         
EGT80990      6 QLIKNIEQWAEDRNLiegsTPQKQFIKLMEEFGELCSGVAKnkp------------------dvIKDSIGDCFVVMVILA 67  Haemophilus haem...
BAK15833      3 ELFKQVEQWSMNKGLdk-aDSSKQFLKVTEEVGEVAAALARndk------------------daLRDGIGDVVVTLIILA 63  Solibacillus sil...
EGS31427      5 DLIKRVQAWGQEKGItdpkNTDKQFLKFMEEALEFKTELDRyvdifwdddys--aafvdytrqnLLLEFGDVLVTLCILA 82  Peptoniphilus sp...
EFT36350      3 KLIKQIKQWADDKGIlakaTPTKQALKTLEECTELLTAIADddg------------------teIKDAIGDIVVTLIIQC 64  Riemerella anati...
EGS34225      5 ELNTKIIEWACEREIdrkgTIQGQAIKTIEEMSELVKGICKndi------------------dlIKDSIGDVYVTLVIGC 66  Finegoldia magna...
ZP_07819228   5 SLVKSVEVWAMNKNLdk-aDPRAQYLKVVEEVGEIAAGLARndk------------------feVIDAIGDSLVTLIILA 65  Eremococcus cole...
ZP_03929760   5 QLQDKVLSWADDKDLlhaeNAEKQFMKFIEEVFEFKTEFDYlvrigedpsecysdyeqietqenMKLEMGDIFVTLIILC 84  Anaerococcus tet...
ZP_08260157   7 DYVTRIIDWAKDREIkekgRLTKQLLKSDEENSELQNAIESyengnk------------daliqIKDSIGDIYVTLVVST 74  Gemella haemolys...
EGQ44328     34 ETQEAIYEWSLEQFGd--qDPENPLIGAQEELGEVSRIVLKekqsirqd--------eefaeedLEVEVADVVIYLLDFC 103 Candidatus Nanos...
ZP_08968716   6 TLQGEVSEWSRENFAd--qPTANPLLGVAEELGELTEHLAVhdcl----------------teyELDCVGDLLVYLADFC 67  Natronobacterium...

Feature 1                                                                                       
EGT80990     68 KQNhidsvletisnldsfqpvfkldveeiiaetvvslg---mlaselmgqnleiptkvdaifgcpclslklisrkyNLML 144 Haemophilus haem...
BAK15833     64 QQN-------------------------------------------------------------------------GMDL 70  Solibacillus sil...
EGS31427     83 KQL-------------------------------------------------------------------------DLDP 89  Peptoniphilus sp...
EFT36350     65 EMQ-------------------------------------------------------------------------NLNF 71  Riemerella anati...
EGS34225     67 MLNntrvctnytldggryrskesmleritnem---------------fklsvcnepydyfnvaklvkllesiaieyKTSL 131 Finegoldia magna...
ZP_07819228  66 KTI-------------------------------------------------------------------------DSSA 72  Eremococcus cole...
ZP_03929760  85 EQL-------------------------------------------------------------------------GIDP 91  Anaerococcus tet...
ZP_08260157  75 YLVserpyltfrkiktskhssvsigwlyfirelktqdr----llfdvftnteatfidievrlssyinflemvaqayGLEL 150 Gemella haemolys...
EGQ44328    104 ARN-------------------------------------------------------------------------DVSL 110 Candidatus Nanos...
ZP_08968716  68 ARRgfdlqaaydtqnpdertyddplygvnaalgrlnrsvlkrrqgirleesrvgdeaerrtistllthlsdfakerGYTL 147 Natronobacterium...

Feature 1              
EGT80990    145 TDCVQAA 151 Haemophilus haemolyticus M21639
BAK15833     71 EECLNCA 77  Solibacillus silvestris StLB046
EGS31427     90 TTCLEMA 96  Peptoniphilus sp. oral taxon 375 str. F0436
EFT36350     72 IDCVQSA 78  Riemerella anatipestifer RA-YM
EGS34225    132 SECVQLA 138 Finegoldia magna SY403409CC001050417
ZP_07819228  73 VECLGTA 79  Eremococcus coleocola ACS-139-V-Col8
ZP_03929760  92 VDCLGIG 98  Anaerococcus tetradius ATCC 35098
ZP_08260157 151 VECIKYA 157 Gemella haemolysans M341
EGQ44328    111 SEGLHEA 117 Candidatus Nanosalina sp. J07AB43
ZP_08968716 148 EECIDVA 154 Natronobacterium gregoryi SP2

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