Conserved Protein Domain Family
hsdM
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TIGR00497: hsdM 
type I restriction system adenine methylase (hsdM)
Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification]
Links
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Statistics
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PSSM-Id: 211578
Aligned: 3 rows
Threshold Bit Score: 640.078
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P75436         8 QRNGVEKKIWEIADKLRGTIDGWDFKSYVLIGLFYRFLSENLCKYFNDSERRNNPDFSYENLTDd-yEAIDALKDAAIAS 86  Mycoplasma pneu...
WP_010875553  13 ERNELHNTIWKVANELRGSVDGWDFKQYVLGILFYRYISENMTHYINKEERKRDPSFDYAKLSD---EKAERGRKHLIEQ 89  Helicobacter py...
WP_005688104   7 QRAELQRRIWQIANDVRGSVDGWDFKQYVLGTLFYRFISENFANYIEAG----DESVNYAQLPDeiiTpdiktdaiktkg 82  Haemophilus inf...

P75436        87 KGFFIKPSQLFQNVVKSIRENknnEDLNTTLRDIFDDIEKStELGDGrSKESFKGLFKDFNVSEVKLGSTLTIRTEKLKE 166 Mycoplasma pneu...
WP_010875553  90 KGFFIPPSALFCNALKNACHN---EDLNVTLQNIFNEIEKS-SLGTP-SEENVKGLFADLDVNSNKLGSSHQNRVEKLTK 164 Helicobacter py...
WP_005688104  83 yfiypsqlfknvaanagnnpnlntdlkqiftdiensatgfpseqdikglfadfdttsnrlgntvkdkndrltavlkgvae 162 Haemophilus inf...

P75436       167 LLTSIDTMELDEFEKNSIDAFGDAYEFLISMYAQNAGKSGGEFFTPQDISELLARIAIGKKDTVDDVYDMACGSGSLLLQ 246 Mycoplasma pneu...
WP_010875553 165 ILEAIGGMQLGDYLKSGIDVFGDAYEYLMAMYASNAGKSGGEFFTPQEVSELLAKITLHGQESVNKVYDPCCGSGSLLLQ 244 Helicobacter py...
WP_005688104 163 ldfgkfednhidlfgdayeylisnyaanagksggefftpqsvskliaqiamhgqtsvnkiydpaagsgslllqakkqfde 242 Haemophilus inf...

P75436       247 VIKVLGkEKTSLVSYYGQEINHTTYNLCRMNMILHNIDYANFNIINADTLTTKEWEkhyvncsNENGFEVVVSNPPYSIS 326 Mycoplasma pneu...
WP_010875553 245 FSKVLG-DKNVSKGYFGQEINLTTYNLCRINMFLHDINYSKFHIAHGDTLLDPKHE-------DDEPFDAIVSNPPYSTK 316 Helicobacter py...
WP_005688104 243 hiieegffgqeinhttynlarmnmflhninydkfdialgntlmepqfgddkpfdaivsnppysvkwagsdnptlinderf 322 Haemophilus inf...

P75436       327 WAGDKKSNLVSDVRFKDAGTLAPNSKADLAFVLHALYVLGQEGTAAIVCFPGILYREGKEQTIRKYLVDQNFVDAVIQLP 406 Mycoplasma pneu...
WP_010875553 317 WVGDSNPILINDERFSPAGVLAPKNAADLAFTMHMLSYLSNSGTAAIVEFPGVLYRGNAEAKIREYLVKENVIDCVIALP 396 Helicobacter py...
WP_005688104 323 apagvlapkskadfafilhalsylsgkgraaivsfpgifyrggaeqkirqylvdnnfvetvialapnlfygtsiavnilv 402 Haemophilus inf...

P75436       407 SNLFSTTSIATSILVLKKNRdKKDPIFFIDGSNEFVREKKNNRLSPKNIEKIVDCFNSKKEEANFAKSVERDKIRESNYD 486 Mycoplasma pneu...
WP_010875553 397 DNLFFGTSIATCILVLKKNK-QDDTTLFIDASKEFVKEGKKNKLKERNREKILQTYIERKEIKHFCALANIEKIKENDYN 475 Helicobacter py...
WP_005688104 403 lskhkpntqtqfidasglfksatnnnileeehieqilklfankedvphlaksvsfeeiaqndhnlavssyveqkdtrevi 482 Haemophilus inf...

P75436       487 LTVGKYVNSEAEKEELDIKVLNHSIDEIVDKQKDLR 522 Mycoplasma pneumoniae M129
WP_010875553 476 LSVNRYVEQEDTKEAIDIKALNSEIAQIVEKQSALR 511 Helicobacter pylori
WP_005688104 483 nidelnaqiretvtnidrlraeidkivaeieg---- 514 Haemophilus influenzae
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