3MGU


Conserved Protein Domain Family
P4Hc

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smart00702: P4Hc 
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Prolyl 4-hydroxylase alpha subunit homologues.
Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.
Statistics
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PSSM-Id: 214780
Aligned: 58 rows
Threshold Bit Score: 79.3542
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MGU_A        51 QPYNWGTIHELVNDDLL-RAvrkEIETEIHfTKk----------ETD---IYRVN-QsgdlanlsGLDWDDLS----RLP 111 Saccharomyces c...
Q62630       152 GEVVGDCVLERVKQLHY-NG---ALRDGQL-AGpra------gvSKR---HLRGD-Q--------ITWIGGNEe---GCE 205 Norway rat
Q9VN98        61 GMETGLKILNEVRSMYN-AG---AFQDGQV-VTnqtpd--apavRGD---KIRGD-K--------IKWVGGNEp---GCS 118 fruit fly
O45918       384 GSDHYKFTAKEIERLYE-RG---LFSPGQL-MEakhk----defHIK---DIRSD-H--------IYWYDGYDgrakDAA 442 Caenorhabditis ...
P74376       169 SATELEQLFKFVIQNEN-NF---LPTSNSA-ND-------------S---DYRRSmF--------LPIFAPFS-----EL 214 Synechocystis s...
Q9KL01        26 NPQEVQALRECIPERWK-RA---KIGRNEE-IQ-----------RAA---DIRSD-K--------IQWLDLSMgq-pVQD 76  Vibrio cholerae
Q9KIT9        12 rTQPFQLFRGRDLLDDGqLD---ELLATVP-TAdvakiavedpkHEK---QYRMn-L--------VDLIVLEK----EAP 71  Streptomyces an...
XP_003270394 199 GAALGGRVLAEVEALKR-GG---RLRDGQL-VSq----------RAIpprSIRGD-Q--------IAWVEGHEp---GCR 251 White-cheeked G...
ZP_01363210   30 PERLTTRLAEECRTRAV-AG---DLTPAAI-GRgdg------qvIRE---GIRGD-L--------TQWLEPGE----SEA 82  Pseudomonas aer...
AAF61921      30 TDAVAEKLRGEFSDDGF--E---ESERTDL-NRs-----------DK---QYRMF-N--------RNLVTAGA----VDE 76  Streptomyces an...
3MGU_A       112 -----NLFK--LRQILyskqyRDFFGYVtka---------gklSGS-----KTDMSINTYTK--GCHLLTHDDVIg---- 164 Saccharomyces c...
Q62630       206 -----AINF--LLSLI-----DRLVLYCgsrl-------gkyyVKE-----RSKAMVACYPGn-GTGYVRHVDNPng--d 258 Norway rat
Q9VN98       119 -----NVWY--LTNQI-----DSVVYRVntmkdng--ilgnyhIRE-----RTRAMVACYPGs-GTHYVMHVDNPqk--d 176 fruit fly
O45918       443 -----TVRL--LISMI-----DSVIQHFkkri--------dhdIGG-----RSRAMLAIYPGn-GTRYVKHVDNPvk--d 494 Caenorhabditis ...
P74376       215 -----IIER--VKAIL-----PQLISDlqi----------qpfQID-----YVEAQLTAHNH--GNYYKVHNDNGspdsa 265 Synechocystis s...
Q9KL01        77 -----YLER--MEQIR-----CEVNRhf-------------flGLF-----EYEAHFAKYEA--GDFYLKHLDSFrg-ne 123 Vibrio cholerae
Q9KIT9        72 -----VFPR--LPGVW-----RDLVEDLrgaeftawlekstgiELA-----GLQRSIGLYTHrnGDYLSVHKDKP----- 129 Streptomyces an...
XP_003270394 252 -----SIGA--LMAHV-----DAVIRHCag------------rLGSyvingRTKAMVACYPGn-GLGYVRHVDNPhg--d 304 White-cheeked G...
ZP_01363210   83 -----CDEYlgVMDSL-----RQALNASlf------------lGLE-----DFECHFALYPP--GAYYQKHVDRFrdd-d 132 Pseudomonas aer...
AAF61921      77 dqvrtLPAN--WQQLV-----ADVVSRPyrealsa--ltgvdlERC-----LVEARMTRYAR--GCWIEPHTDRP----- 135 Streptomyces an...
3MGU_A       165 SRRISFILYLP----D----PdrkwksHYGGGLRLFPSIL--------P--NVphsdpsAKLVPQFNQIAFFKVLPgFSF 226 Saccharomyces c...
Q62630       259 GRCITCIYYLNknwdA----K------LHGGVLRIFPEGK--------S--FV------ADVEPIFDRLLFSWSDR-RNP 311 Norway rat
Q9VN98       177 GRVITAIYYLNinwdA----R------ESGGILRIRPTPG--------T--TV------ADIEPKFDRLIFFWSDI-RNP 229 fruit fly
O45918       495 GRCITTIYYCNenwdM----A------TDGGTLRLYPETS--------M--TP------MDIDPRADRLVFFWSDR-RNP 547 Caenorhabditis ...
P74376       266 TRELTYVYYFNre-pK----A------FSGGELAIYDSKIennfyvaaE--SF------KTVQPVNNSIVFFLSR---YM 323 Synechocystis s...
Q9KL01       124 NRKLTTVFYLNen-wT----P------ADGGELKIYDLQD--------N--WI------ETLAPVAGRLVVFLSER--FP 174 Vibrio cholerae
Q9KIT9       130 TKAITVILYLNrd-wP----V------EAGGQFQIFASPKe-------G--PT------EEISPVGGQLLAFPPTD-KSW 182 Streptomyces an...
XP_003270394 305 GRCITCIYYLN----QnwdvK------VHGGLLQIFPEGR--------P--VV------ANIEPLFDRLLIFWS-DrRNP 357 White-cheeked G...
ZP_01363210  133 aRTVSAVLYLN----Daw-lP------EHGGALRLHLPQR--------Q--V--------DIQPTGGSLVVFMSAG--TE 181 Pseudomonas aer...
AAF61921     136 DKAVTHLFYFNdg-wD----P------EWRGDLRLLRSAD--------MadCA------KRVAPTTGTSVV-LVRSdRSW 189 Streptomyces an...
3MGU_A       227 HDVEEVKVd-----KHRLSIQGWYH 246 Saccharomyces cerevisiae S288c
Q62630       312 HEVQPSY-------ATRYAMTVWYF 329 Norway rat
Q9VN98       230 HEVQPAH-------RTRYAITVWYF 247 fruit fly
O45918       548 HEVMPVF-------RHRFAITIWYM 565 Caenorhabditis elegans
P74376       324 HEVLPVNCpsqafaDSRFTINGWVR 348 Synechocystis sp. PCC 6803
Q9KL01       175 HEVLEAH-------ADRVSIAGWFR 192 Vibrio cholerae
Q9KIT9       183 HAVSKIEHpe---gTERITVQIEYW 204 Streptomyces ansochromogenes
XP_003270394 358 HEVKPAY-------ATRYAITVWYf 375 White-cheeked Gibbon
ZP_01363210  182 HEVLPASR-------DRLSLTGWFR 199 Pseudomonas aeruginosa PACS2
AAF61921     190 HGVPPVadtcpvdrrallvhfvrp- 213 Streptomyces ansochromogenes
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