DNA-binding domain of T-box transcription factor 22 and related T-box proteins
TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
Comment:based on related T-box transcription factors bound with DNA
Comment:T-box monomers dimerize upon DNA binding; some form weak dimers, others tight dimers, some may bind as non-associating monomers where the dimer is kept in register by the DNA
Jiyao W et al.(2023). "The conserved domain database in 2023.",