Conserved Protein Domain Family
E3_UFM1_ligase

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pfam09743: E3_UFM1_ligase 
E3 UFM1-protein ligase 1
The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organizms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.
Statistics
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PSSM-Id: 462874
Aligned: 51 rows
Threshold Bit Score: 233.207
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH60340       3 EILALQAQLASAQDAKS---SFRLNERNVIELVGKLKKLGYLd-dTLMHTLDGKEFVTVEQLRKEIAEEVRASGGRVPVF 78 
ESS30027       3 SLEELQRQFMAVQEAAP---TQMLSERACVDIVVKLMEKKKI---QLVTTTNGKEFVTLETLAQEIRTHLANHKGRVNVI 76 
Q4MZ62         3 SISELRSRLASAQSTKS---KLRLSNLQCIDLLLKICKKKGV---DLITSTDGMLFYTLEEVQAEVENELLSRGGRIPIF 76  Theileria parva
CDS38373       6 EVRNLAEKLRSVQASES---THYLSERICVDIVSYLTKSGRL---RLVRTIDGRAFLTENELFKEIIEELAARRGRISLL 79 
A0E4Z0         3 ELFALQQQLAEIQETST---KYRLSDRIIIDLIEKLVKEYDL---KVYHSTDGQSLVTPNQLSKEIHQLILSN-KRVAVN 75  Paramecium tetr...
Q22YA0         3 EILELQRLLAEVQEQTC---TNKFSDRVIVELVNKIINDYGL---HLIYSQDGQEYMTPEHLDEQLAQLISER-GRIQVL 75  Tetrahymena the...
XP_004024371   5 EILELQRQLAQIQEQTT---QNKFSDRVIVDLINKLIQEYNL---TLIYSSDGQEYMTPEHLDNQIQQLTQEKG----VQ 74 
EFC39553      10 SIEQLQQQFEQVQQESLsggSYKLNEHNIIELIQYIKKQDPNfaeQLCFTSDGKEYITRDQIEYELQILLEKYGGRINKN 89 
Q4E139         5 DLSELVKKFQAIQRQTF---PDQIGERNVVEIINVLREKQLV---DLLYTLDGKEYLTWDQLRREVVDEIVFNGGRMNVV 78  Trypanosoma cruzi
Q38AF6         5 ELSELIRKFQAIQRQDI---PNQITERNVVEIVNVLQRKKFV---DLLFTVDGKEYLTWDQLRREVIDEVHANGGRMNVT 78  Trypanosoma brucei
EEH60340      79 DLQSALNIDVHHCEREAKFL---AADAtAG-LSLVEG--ELMTPAYFDGVAAEVEEELRELGVVAV-------------- 138
ESS30027      77 EMATALGVSPDIVEAKTEEM---TRRS-RH-LMLLDG--DLISTLYLNMIAGEIENLLEEKGQLTI-------------- 135
Q4MZ62        77 ELNSVLNFQPDHIDRAVSNI---VKPG-GE-YLNSHG--VIISKQYLERLMHSIDDRIQECGTVAI-------------- 135 Theileria parva
CDS38373      80 EISKNLEMEYSVIESHVNELlskPYEYlDEqCLLVAG--ELMTKSFIRRIAEEIRDRLKFRGAESM-------------- 143
A0E4Z0        76 QLPEILGIGFDKIEGQIEKD--------SNgWDVVRMqdEMMSHDYILNVCEEINEDLQQKSIISL-------------- 133 Paramecium tetr...
Q22YA0        76 EIPPILNVTEDVVENRVPKI---IKKN-KKdFIRVGN--EVITSNYLNQICEEINEDLQQQSQIFL-------------- 135 Tetrahymena the...
XP_004024371  75 TLQTIHNYQMLILKQS-----------------------KVVYLKYQRKTNENSQDQKTKQQQVHIqtkyvkiqmkiysk 131
EFC39553      90 ELPKLLRVDFTYLEQPIHNL---IQKQ-IVlPDLINGc-EILTPSYLESVVMEINELLKLSGYIYI-------------- 150
Q4E139        79 DLPGSLNVHFTHIERVLQDV----LED-PT-IRIESG--ELLTDEYLDSTIQAAADVLKENGFLSI-------------- 136 Trypanosoma cruzi
Q38AF6        79 DLPGLLTVHMIHIERVLPEV----LEE-PN-IRLEAA--ELMTDEYLDSTVSAAQDVLKEKGFVAV-------------- 136 Trypanosoma brucei
EEH60340     139 ------ADLARAHGLSADLMSR-ALR---ERVgdGGIVSGRMEGGLLYTPQYVARITAQLRGAMRAALTPTTRdALVTNA 208
ESS30027     136 ------AELSQKYSLPAEFLRQ-EIH---ARL--GTVIHGELKNQYLTTAHFSRRVESIVRGVLTAACRPVAV-SAIATE 202
Q4MZ62       136 ------SDLSKEYDLPLEMMRT-YVS---ANL--GSIIKGNINGNLIESLTFEQRKINNFLASVLAITMPIST-NDLSRI 202 Theileria parva
CDS38373     144 ------IELSRVYNFTPQFLAS-IIS---DYN--GVLFNVHRDGDKLYTHIFMSKQKSKVMGYLSAVVAPISL-ADCGSK 210
A0E4Z0       134 ------QEIMQKYALPMQFVTKyILKq------vGAVIQGVCnEDKLTTVTYQEIMTAKLCGILRATLSPVSF-LKLNKD 200 Paramecium tetr...
Q22YA0       136 ------FELTSKYSLTLQFLKEqLQYridNNIidGNII-----GDKLCTLTYQELTKSKFRGLFRGATKPILL-SSLAKD 203 Tetrahymena the...
XP_004024371 132 drkyclQKQAKIYNLTMQFIKDqLQSridQRIidGNIVG----GEKICTSTFQLLMKAKLRGSLRAATKPIVL-GNLSKE 206
EFC39553     151 ------GTLTKQLFLPSDFIKEhIITkymHLLlnGTIFS----NNSLYTEKYINNLKSITIGICNSITSRSMEcNDLLKV 220
Q4E139       137 ------AEFAKTHRFSSVFAQD-LLM---KAVesQR-LRAVAERSAMYTTQFVHSQKAILRAGLMAATRPVNL-TTFFER 204 Trypanosoma cruzi
Q38AF6       137 ------SEFARIHRFTSLFAQN-LLT---GAVesGR-LRAVLQGGALHTKQFVGAQKVVLRAGLLAATEPVNL-TTFFER 204 Trypanosoma brucei
EEH60340     209 lrgcdgdgdggdgggggvgdgrgtgAELTGSIVG--ELGKN-VDA--SGLDGVFQRG--AWQPAAYSRAQTAAVGDLYAT 281
ESS30027     203 -------------------------FNLPNDSVT--NAAVQlIRL--AQLQGRLQSG--IFTPARFSTGQSDKVTSFYKA 251
Q4MZ62       203 ---------------------------IKQNINTvnDTLGNlIKQ--GNVNG-FIKGn-eFVPQCYINSVDTFLTHYYAR 251 Theileria parva
CDS38373     211 -------------------------LDIPLKVLS--SLIDTlISS--GKLKGTLTAGksLYAPLCYRKAQDIYISDFVKQ 261
A0E4Z0       201 -------------------------LEIQNSQ----KICEQlLIT--KQIDGKIFSGq--YVSSRFLQNQEAQVKSFFDQ 247 Paramecium tetr...
Q22YA0       204 -------------------------YQIEQRQLQ--EIIEDlISS--EAIEGKIISGq--FVPTRFQRNQENTIRDFLKQ 252 Tetrahymena the...
XP_004024371 207 -------------------------FGIENKVLQ--EIIEElINQ--EYIEGKIHTGs--FIPQKFQKNQENIIRNFLKQ 255
EFC39553     221 tkkfylmne-------sngneyaddIEIELELYQ--NIVKDlIKN--KQINGTLQVNstLYVPNIYEKMATDQVCKFIHS 289
Q4E139       205 -----------------------------HNLFV--PLMDPvIDAvrAELPGKFVGGv--YVPTYFEVTRAEQVENVYLS 251 Trypanosoma cruzi
Q38AF6       205 -----------------------------HNLFA--PLVDVlIEAvrNDLPGK-IEGr-vYIPTYFEQDRANEVENVYLS 251 Trypanosoma brucei
EEH60340     282 AGIVTIDQATR-MGVERPREYF 302
ESS30027     252 NAFVPFSLAKD-CGFSDAHGFL 272
Q4MZ62       252 NGYIEVSLINS-FHYFTTNTIN 272 Theileria parva
CDS38373     262 NGYVEWTTVQR-VGIPDPSSYL 282
A0E4Z0       248 NSYVEYDKLHQqFFIQKPKEYL 269 Paramecium tetraurelia
Q22YA0       253 NKYIEYSMLQK-LFIQKPEETL 273 Tetrahymena thermophila SB210
XP_004024371 256 NNYIEYSMLQKqLYVQKPQDTL 277
EFC39553     290 NGYVSVERVESmLGYK----AF 307
Q4E139       252 NGFIEYASLHQ-HGISQAKEFL 272 Trypanosoma cruzi
Q38AF6       252 NGFIEYALLHR-KGITQAREFL 272 Trypanosoma brucei
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