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dATP/dGTP pyrophosphohydrolase This domain is found in phage proteins, such as A0A2H5BHG5 from Acinetobacter phage SH-Ab 15497, which are associated with PurZ, an enzyme that catalyzes the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity. This domain has dATP and dGTP pyrophosphohydrolase activity; it catalyzes the hydrolysis of dATP/dGTP to pyrophosphate and dAMP/dGMP, respectively, with little or no activities for NTPs and pyrimidine dNTPs. It is suggested that enzymes containing this domain supply dGMP as the substrate for PurZ, elevating dZTP level to promote Z incorporation. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",