Conserved Protein Domain Family
TAF1_subA

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pfam14929: TAF1_subA 
TAF RNA Polymerase I subunit A
TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.
Statistics
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PSSM-Id: 434323
Aligned: 34 rows
Threshold Bit Score: 207.96
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEF44021          76 KLVRQHCWTEASGVLSVLLKGTCKENHPTMNRFKYLVSMEFIKHlet--------dnvNLTSVNQIYDIWMTRIGINLSS 147
JCVI:AT1G53200.1  82 ELLRNRHWNDASRVLSVLMKGTINDPCPKMNRLKYEAHIQIVSHset--------nknKADEIGRIYDTWIGQIGk---- 149
XP_009144786      73 ELLRQRKWREASCVLSVLMQGTMRDGSPSMNRLKYEAQIQIVSHlqp--------dknNVEEIERIYDTWIGKIGk---- 140
XP_004251881      80 KLMRQHKYAEASGVLSVLLKGTTKESAVFKTRTKFMAILELIEHikg--------dtiSSKRIQDIYELWMKKLGpmk-- 149
XP_014621377      74 RLVNQHHWVAASGVLSAYLKGTLDDASPYTNRLKFWVLLELLKRven--------hsiNPTRIKNLYDIWSKKIGsmk-- 143
EER88152         135 ELAGAHEWRDAASVVSTLLSGNRRVDSYEDTRRMFVVAMEIHKRlaedsgvqhgvrssYYLRTQKLFNVWMRKLIWFPSC 214
XP_006656838     154 ELVRAHRWRDAAGPFSALVAGTRYPESFEELRSVFAVGMEIHRRhfenggmklgarsrYYLRTLKLYDVWVRRLGWLLTC 233
BAJ99492         211 NLVRSHQWRDAAGVFSVLLPGIQRPDSFEEARSILVDAMDIHRRlaqds----ggrrtYCHRTQKVFDVWIQRLMWLPTC 286
KQK18768         214 DLARAHKWHDAAGVFSALLPGILQPDSFGEAHRIFVDAMEIHRRlaedsgiqlggrsrYYLRTLKVFDVWMRRLIWLPTS 293
ERN07694          48 KLMRKHKWKEAAGVLSLYMQGTHNHKAPFQNRRKYSAALELIRQikg--------pkhDLHRLQRIYDLWSHKQRLYKYS 119
EEF44021         148 KRKRngsmkehYlwflffcKLFDLNDYFAHLFLFSFFFFFcsLMQESEFEGhpMFNMIVGLIFSQLCYSNIPEDMKCKds 227
JCVI:AT1G53200.1 150 ----------qHkeerllvWYEQICHFIEHEMNNEAYSTVisLMQNRDFAMlpRANLFIGISFYKMWCNKFLKELQPEda 219
XP_009144786     141 ----------qHkeerllvWFEQICHLLEHGMEKEAEYAAigMMRSRDLGNlpRTNLYIGITCYRLWCRKYSEELEPKda 210
XP_004251881     150 ---------nrPpkdrfavHLEFILFCLKRGNTQDAHQGAlsLMQQRGFGSdpVSNLVVGLVFYQLWYSTIPKELHLQel 220
XP_014621377     144 ---------twPvesryavHMEFMLFCLLQGNAEDAYQLAlcLGQEKGDIGp-MSKMMMGLTFYELWYSSIPKEFQWRns 213
EER88152         215 PKKnl-------------vTLELALFYLSQGNIDNAHIATrtLIAKGKLQTepILNLVHGLISFDKWYSGLPKDMQVEdf 281
XP_006656838     234 ANKhl-------------vKLELALFYLSQGNIDNAYNTTriLIAMDGLQTepTVNLIHGLISYDKWYSGLPKDMQLEdf 300
BAJ99492         287 TKKhm-------------vKLELALFYLSQGKIGDAHNATrvLLTKDGLKMepTLNLIHGLISYDKWYSGLPKDMQLErf 353
KQK18768         294 AKKhl-------------vKLELAMFHLSQGKIGDAYNLTksLIAMDGLQTepTLNLIHGLISYDKWYSGLPKDMQLEgf 360
ERN07694         120 LYKNsy-----------liRLEYALHFFAQGNIQEAYNISniLVLKSESRRdpLVNMIHGLILYHRWYSGIPEELHFRas 188
EEF44021         228 nqirgptythmsvttqldmsatgfrnevggseghnslfddesescfrctsetsimnckempvkvnndlqeevlpveidvn 307
JCVI:AT1G53200.1 220 ddngsvsnisesgsgslvecsgrdesvcslasevsarkdsetsvmknkkvshlsisdsetr------------------- 280
XP_009144786     211 dcsdsisnmsqsgsgvmaecsprnesvysvessgsvrnvseasvgncevnsdastrdsgsvvev---------------- 274
XP_004251881     221 drfdstvqsetfedrifmsilnseehdavegeeanspfncdsntsirndkeilgvdvsqqreva-------mvdddnvpg 293
XP_014621377     214 dqfdsqensdmegtsfnnetvqsemynsveshmadsqsqrdsdasvmndmkisgdvvfned-------------mevdan 280
EER88152         282 dvydescgismksngsegtdlldhsyedsmdivqsslascssessinnenvgrk-------------------------- 335
XP_006656838     301 dvygqsctvstathgcdengqqdssddncsidsdssfdgcssqssinngnidtqrkip--------------------kk 360
BAJ99492         354 dvydesckisvssnacgdkglqdssddncsidvddasfpacssessinngnidkicki-------------------pkq 414
KQK18768         361 diyneactisvesngfgenrlqdssndncsidvddaslpscssqssinienidkkwki-------------------skk 421
ERN07694         189 dadmpllclepdlssasneqsatvnsrnsptvntsnhhalanisgggvdcvfdsdssicmdkvphds--sggefpkleia 266
EEF44021         308 lqtnvpqdfqpqafyvnsaedevsvdnngdghmhfvpnlsafksgdswllplrtenwE-------LKWVIQADEYNHAVR 380
JCVI:AT1G53200.1 281 --mdtkvkvmstpyvtpppqlyaiseeneaslgdgivefdptvinilgdmdpwllpfkppedpdcYRKIVNDSYYKEAVK 358
XP_009144786     275 kvklenvkveescqhfteppriyasseeneeplrdgvsfdpalvqilgemdpwllplkppedpdcHGKIVSDSFYKDAVS 354
XP_004251881     294 etqndnfqpqdfymnssersdregssmdqsgddpyhsifynrglplwllplqlpssdEnledvlnMHRALRNDNYKNAIK 373
XP_014621377     281 krekpyqnvqpegfylnseehkgfgdpfsnnggltqdilyglggldswllplrfsddHsfeefmyWQGNQPNDFYKNAVK 360
EER88152         336 -mnnkpgfvhpkeeidplesqanenlrsifldtsdgptcgleqsllplklkfatgasNdsfykymKYKSVPNTLYEDAEK 414
XP_006656838     361 pgfvhsteetgslgsqvneknvdtdfqsvffnasnsptcgleksllplrlkhsdgasNacfdsywKYKSTYNAFYEDAEK 440
BAJ99492         415 shfvypvkendsvdsqvkeevvsedfrsvffntsdaptcgleqtllplrlkhaagnsSecfdsywKYKSTPNTFYTDAER 494
KQK18768         422 pgflhpvkendsvgsqvneevvdtdfrsvffntsdsptcgleksllplrlkcapdtsNdsfdsywKYKSTTNSCYEEAVK 501
ERN07694         267 pilmlqnydsagqeeigvtevystaedeisegisiydlfrlgpsllplqfqtslesgE-------YPIVLTNDDHNEAVK 339
EEF44021         381 YLqsAVYSTPPV-FAALIPLIQLLLIGRKYREALDELeKFCgNLNAALPIRLRAHLL-ELVDPKNTVVISScfedTLKTD 458
JCVI:AT1G53200.1 359 YMrqTLQSPPHVsLAALHPLVQILLIGGHVDEAMKVVeEMCnKIHDVKPFRIKALMM-EKFHRNS-DMLAKcyedILKID 436
XP_009144786     355 YLrlTMQSPRYVsLAALHPLVQLLLIGGRVDEAMKLVeEMCnKVHDIKPFRIRAAMK-EKFHNNS-DELAKcyedVLKID 432
XP_004251881     374 YLrhALHSSPPV-LEAFHPLIQMLLLGDQVKEALDEVeKFTpYTNTSFQLRLKATIL-EHFDSGNYVKLSAiheeNLEKD 451
XP_014621377     361 YLqlALDSEPSA-SAALLPLIQLLLIGGQVDEALNMLeKQCcNSASVLPIRVRAALL-ERFDRNNSPLLLScfedILKKD 438
EER88152         415 CLrlALYSNPPV-MAALLPLIQILLLGDKLKDALNELeKAClSSTTALPFRLRGRLLeEY-DQNQVSTISScyeeALRRD 492
XP_006656838     441 CLrvALYSTPPI-MAALLPLIQILLLGDKLKDALAELeKIChSSTTQLPFRLRGRLL-EYFDQNQVSTISScydeALRRD 518
BAJ99492         495 CLrvALHSSPPV-MAALLPLIQILLLGDKLKDALCELeRTCrGSTTALPFRLRGRLL-EYFDQNQVSTISScyeeALQRD 572
KQK18768         502 CLrlALHSSPPV-MSALLPLIQILLLGDKLKDALVELeETCrSSTTALPFRLRGRLL-EYFDQNQVSTISCcyeeALRRD 579
ERN07694         340 HLriALYSKPPV-LAALLPLIQLLLLGNQAQEALMVLkEFChNSDFILPNRLRVRLL-ECFCRENSALIRRchedVLQRD 417
EEF44021         459 pTCRMSLDKLISLHQKgNYSPESLLEMIALHLEAVFGEYKIWKEFALCFlQvsqyeedcmsa-----clygdegkkiqGY 533
JCVI:AT1G53200.1 437 pCCITTLKKLIGMCLEdEYSRESLTEMIALHVEASFPEPEIWKELASCFsNffenldedrlsv---cldgsedkrnpqTY 513
XP_009144786     433 pSCVTTLKKLIEMSKEdGYSRESLIEMIALHVEASFPEPQIWKEFAEMLiLffenvdedrmsv---clnrdgeegcqqTY 509
XP_004251881     452 pACSHSLGRLIILHRRgEYSTEKLMEMIALHLDATHANCDTWKELACCFlRlfqceedcmsv------csngedsekqKF 525
XP_014621377     439 pTCSDALAKLIKMHQNgDYSLESLLEMIALHLDATHAEYNTWKVFSSCFlRlssyeedcmss-----cpvqnedghkqHF 513
EER88152         493 pTCSYSMERLIKMHRKgYYNVIQLLEAIALHLDSVNGKPCIWEELVSCFlRlfsdntadyed-----cisctnthgdeAL 567
XP_006656838     519 pTCSYSMQRLIRLHRKgYYNTIQLLEAIALHLDSVNGKLCIWEELVACFlRlfsdqttdcgd------cmscnvqgdgTF 592
BAJ99492         573 pTCSYSVERLTEMHRKgYYNTTRLLERIALHLDSVNGKPFVWEELVSCFlRlfsdrttdyed------ciscnvegeaSI 646
KQK18768         580 pTCGHSVERLIEMHRKgYYNSVQLLEAIALHLDSVNGKPFIWEELVSCFlRlfshrtadyed------ciscniqgdtAI 653
ERN07694         418 pTSEESVLYLIDMYTEgKYEVQQLLEMIVLHLDAAYGTSYIWGQLASCFlSlqgtllsqpdvdqlsiiqhgseycehaSL 497
EEF44021         534 SvrYNRIPkLFICGRsginWRFRCRWWLTRHFSKKLLVSEIAAgn-------lEF---LaYKAACAAHMYGTEFDYFVKA 603
JCVI:AT1G53200.1 514 SvrYNPTPkTFTKt----sWTLRAKWWLNRHFSPQMLETEIKNvtlt---gdwEM---MtYKAACASYIYGREFGYVTKV 583
XP_009144786     510 SvrYNRTPrMFTGt----sWTRRAKWWLNRHFSPEILETEMKKleaeqingdlEMlrlMsFKAACASRLYGPEFGYVTTV 585
XP_004251881     526 TkwISQIPkIFSDYEssksWRLRCRWWLTHYFSQTILTSDIASgd-------wEL---LtYKAAVACYLYGREFKYVVKA 595
XP_014621377     514 Sl--NKTPkIFTDGIsgksWRLRCRWWLTRHFSNSKLESEIEAgd-------lQL---LtYKAACASYMYGREFSYVAKA 581
EER88152         568 Ev-SSKLSsVFFERFtresWKARCKWWAHHHFSQNAYTSETRSgd-------cKL---LaAKAACAAHLFGPEFPYVKAV 636
XP_006656838     593 Ta-SSNFAcVFFEQHtretWKVRCRWWMNHHFSQNICTSETVTgd-------cKL---LvSKAACACHLYGPEFRYVKAV 661
BAJ99492         647 Np-FSSLSsVFFEQHtresWKLRCKWWINRHFSQNIYMSETAKgd-------sKL---LaSKASCASHMLGPGFPYVKAA 715
KQK18768         654 Aa-FSSMSsVFFEQHkresWKLRCRWWMNHHFSQSIYTSETLKgd-------cKL---LaSKAACATHLFGPRFKYVGAV 722
ERN07694         498 SlsSNPIPqAFAGHEsrkaWRLRCRWWSNRHFSSKAYVLDEQAdg-------mEL---LvSKTACALHLYGVECEYVKSV 567
EEF44021         604 YT 605
JCVI:AT1G53200.1 584 YE 585
XP_009144786     586 YG 587
XP_004251881     596 RE 597
XP_014621377     582 YS 583
EER88152         637 GS 638
XP_006656838     662 ES 663
BAJ99492         716 KS 717
KQK18768         723 NN 724
ERN07694         568 LH 569
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