Conserved Protein Domain Family
7tmA_OR2B-like

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cd15947: 7tmA_OR2B-like 
olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320613
Aligned: 28 rows
Threshold Bit Score: 398.15
Created: 16-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q9GZK3        25 IPPFVMFLFSYILTIFGNLTIILVSHVDFKlhtpMYFFLSNLSLLDLCYTTSTVPQMLVNIcntrKVISYggCVAQLFIF 104 human
O95371        25 MIFFIAILFSYLLTLLGNSTIILLSRLEARlhtpMYFFLSNLSSLDLAFATSSVPQMLINLwgpgKTISYggCITQLYVF 104 human
NP_666744     27 LPLFFVLLTSYMFTLLGNIAIILVSQLDSQlqspMYFFLTSLSFLDLCFTTTTVPQMLFNLqgpnKNITYigCMAQAYVF 106 house mouse
EHB14564     305 RPLFGMVLLSYVLTLVGNSSIILLSLLDPRlqmpMYFFLDNLSLLDIGVTCTIVPQLLTNLwgqdKTIASwgCITQVYFF 384 naked mole-rat
NP_001001007  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQldspMYFFLSNLSFLDLCFTTTTIPQLLRNLwgpdKSISYrgCVTQFYIF 104 Norway rat
Q5JQS5        29 LPLFVVLLLSYVLAMLGNVAIILASRVDPQlhspMYIFLSHLSFLDLCYTTTTVPQMLVNMgssqKTISYggCTVQYAVF 108 human
NP_001000268  25 LPLFIILLVTYPTAMIGNIAIILVSTIDPSlhspMYFFLTNLSFLDMCYTTSIVPQMLINLggstKTISYmrCAIQLYFY 104 Norway rat
NP_001000023  29 MPLFGVLLVSYIFTMIGNSSIIILSLLEPRlqtpMYFFLDNLSMLDLCATCTIVPQLLVNLwgpeKTIASwsCITQSYLF 108 Norway rat
XP_004841248  65 RPLFAVVLISYFLNLVGNSSIILLSLEDPRlq-tPMYFLDNPSLLDLSVTCGTVPQMLAKLwgphKTIAAwaCITQGYIL 143 naked mole-rat
ELR55964      28 MVLFWIVIFLYTMIILSNMTIILLSYMNPQlytpMYFFLSNLSFLDLCFTTTVVPQMLFNLwgpdKSITYigCIIQLGMV 107 Bos mutus
Feature 1        #  #                                            # #####                         
Q9GZK3       105 LALGSTECLLLAVMCFDRFVAICRPlhYSIIMhQRLCFQLAAASWISGFSNSVLQSTwtlkMPLCGHkEVDHFfCEVPAL 184 human
O95371       105 LWLGATECILLVVMAFDRYVAVCRPlrYTAIMnPQLCWLLAVIACLGGLGNSVIQSTftlqLPLCGHrRVEGFlCEVPAM 184 human
NP_666744    107 HWLGCTECVLLGIMALDRYVAVCKPlrYSVIMdHRLCLQLSGAAWLTGLANSLLQSTltiqLPLCGNrMLDHFfCELPGL 186 house mouse
EHB14564     385 NWTACAECILLAMMAIDRYVAICQPlqYTLIMhPRVCVQMAAASWSSGLANSLLQTIstlqLPLCGPhTLDHFfCEVPVL 464 naked mole-rat
NP_001001007 105 HFLGATECILLAVMSLDRYIAICKPlrYPAIMhQQFCILLMFMTWLSGLANSLLQSTltvkLPFCGNnKVDNFlCEVPVM 184 Norway rat
Q5JQS5       109 HWLGCTECIVLAAMALDRYVAICKPlhYAVLMhRALCQQLVALAWLSGFGNSFVQVVltvqLPFCGRqVLNNFfCEVPAV 188 human
NP_001000268 105 HTMGGTECVLLALMSFDRYIAVCKPlhYTLIMkQRNCVLLVSIVWLIGISYAVTEATvtlqLPLCGHnKLDHLvCEIPVL 184 Norway rat
NP_001000023 109 HWTSCTECALLAVMALDRYVAICCPlrYVLIMhLWACVWLAAVCWASGLANSLVQATltlyLTLCAKnTLDHFfCEVPAL 188 Norway rat
XP_004841248 144 NWTASAECILLAMMSIDHYVAICWPlqYTVIIcPWACVHMAAPSCSSRLLNSLLQTTltlqLPLCRQhTLDHF-CELPVL 222 naked mole-rat
ELR55964     108 LCVGATQGVMLVVMAFDRYVAICQPlrYTIIMhPQFCWKLVLMSWLSGLIESVTQTPitfqLPFCVHhCLDDFvCQVPSL 187 Bos mutus
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q9GZK3       185 LKLSCvdttaNEAELFFISVLFLLIPVTLILISYAFIVQAVlriqsaEGQRKAFGTCGSHLIVVSLFYGTAISMYLQPps 264 human
O95371       185 IKLACgdtslNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVlkirsaEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPak 264 human
NP_666744    187 IKMSCgdttvNEVTLAVVATFFIMGPLSMILVSYSYIAQTVfrmpsaAGRLKAFNTCSSHLLVVSLFYGPGIYIYMQPse 266 house mouse
EHB14564     465 IKLACgdttaNELALSIGAIPFGMLAPLLVVVSYIFIARAIlklpsaEGRHKALSTCSSHLLVVTMYYGPAIYVYFQPp- 543 naked mole-rat
NP_001001007 185 IKMSCantafNIAMLSIVGTFYSLVPLSLILVSYGFIVATVlrirssEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPss 264 Norway rat
Q5JQS5       189 IKLSCadtavNDTILAVLVAFFVLVPLALILLSYGFIARAVlriqssKGRHKAFGTCSSHLMIVSLFYLPAIYMYLQPps 268 human
NP_001000268 185 IKTACgeketNELALSVVCIFLLAVPLCLILASYASIGHAVfkikssEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPps 264 Norway rat
NP_001000023 189 IKLACsdttmNDLSLALGAIPFGIVSPLTVLISYIFIARAVlklpsaEGRRKALSTCSSHLLVVTMFFGPGMYTYLQPp- 267 Norway rat
XP_004841248 223 IKPAFgettaNELALVIGPIPFARMAPMLVVTSDTFIARALlklpsaESRHKALSTCSSRLLVVTMYFASAMYVQLQPp- 301 naked mole-rat
ELR55964     188 IRLTCgdtstTEWQMTISAVFFTILPMGLILTSYGYIAQTLgkiqseEGRQKAIATCSSHLTVVFMFYGTVAMVYTDPkn 267 Bos mutus
Feature 1           ## ###  #  ##              
Q9GZK3       265 psSKDRGKMVSLFCGIIAPMLNPLIYTLRN 294 human
O95371       265 nsKQDQGKFISLFYSLVTPMVNPLIYTLRN 294 human
NP_666744    267 dgSQDLIKVLTLFYCVITPMANPFIYTLRN 296 house mouse
EHB14564     544 -aKSSQTKFMSFFYCVITPVLNPLIYTLRN 572 naked mole-rat
NP_001001007 265 ssSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294 Norway rat
Q5JQS5       269 sySQEQGKFISLFYSIITPTLNPFTYTLRN 298 human
NP_001000268 265 siTKDQPKFMALFYGVVTPTLNPFIYTLRN 294 Norway rat
NP_001000023 268 -gNSTQSKLLSFFYCVCTPLLNPLIYTLRN 296 Norway rat
XP_004841248 302 --KNHTQAKFMSFYXVITPVLNTLIYTLRN 329 naked mole-rat
ELR55964     268 hfASKHGKFVSFFFTVITPLLNPLIYTLRN 297 Bos mutus

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