4LRH,5F4Q,5JYJ,6HCE


Conserved Protein Domain Family
Folate_rec

?
pfam03024: Folate_rec 
Click on image for an interactive view with Cn3D
Folate receptor family
This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.
Statistics
?
PSSM-Id: 397250
Aligned: 34 rows
Threshold Bit Score: 85.5909
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4LRH_H        14 VCMNAKHHKEKPGPEDKLHEQ--------CRPWRKN-------------------------------ACCSTNTSQEAHK 54  human
XP_006117388  22 RCLEGETHKPRPSPEPDMHE---------CTLYSES-------------------------------SCCYANFTEQLAH 61 
Q7T3I8        28 VCLQDGKHKATPSPEPHLTE---------CSLYADN-------------------------------SCCTEEQIQDMSH 67  Nile tilapia
Q5DRQ5        27 AC---GGSHQFQARSQGHLGL--------ASNLGTNqvqlagdlqasgpqpymmiqdpdsqafplpePCCPSEMDTPETS 95  thirteen-lined ...
Q8QZY4        27 AC---GWSHPLQTRSWGHPGL--------AAKVRTGqlqpaghpqssvlpsypriqvpgsqtppvpvPCCTAEIDRPES- 94  house mouse
Q9BSG5        27 AC---GGSRPLQARSQQHHGL--------AADLGKGklh-------------------------lagPCCPSEMDTTETS 70  human
Q4TUC0        27 AC---GGSRPLPALSRRHHRL--------AADLGTG-------------------------------QLHLAEMDTPEAS 64  dog
Q0IHI5        24 KCLPGRTPNLLPEAEANLLQ---------CQQYSEK-------------------------------ACCTQEQINAHP- 62  African clawed ...
Q14DK5        28 QCL--DFRPPFRPPQPLSF----------CAQYSAF-------------------------------GCCTAEQDAALAR 64  house mouse
Q69GM1        38 RCLNGSSPRRVKKRHRKLQTLdlggagegCRGLYPRl------------------------------SCCPKTDIPGMPM 87  African clawed ...
4LRH_H        55 DVSY-LYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPW-IQQvdqsWRKERVLNVP-LCKEDCEQWWEDCRTSYTCK 131 human
XP_006117388  62 SPVIkVSHSSWDRCGELSKSCEEYMKKIECFYRCSPHAAHW-INP----NYTSGIKLVP-LCQNFCDDWYEACKSDLTCV 135
Q7T3I8        68 VPSVnNQNEPWDKCGSLSPECEGFLKRVSCFYRCSPDAARW-PHP----QRRSYIQAVP-LCHSFCRDWFDACRMDLTCA 141 Nile tilapia
Q5DRQ5        96 GPGI-----FPPRCRTPSSGCESFLGHLQRALRNRFHLLLLgVRQ-----------APP-LCEELCQNWFATCEADITC- 157 thirteen-lined ...
Q8QZY4        95 ---------LLESCGAPSPECEFFLGQLQGALRDRFHPQLFgARP-----------VQP-LCPELCQIWFTTCQADFIC- 152 house mouse
Q9BSG5        71 GPGN-----HPERCGVPSPECESFLEHLQRALRSRFRLRLLgVRQ-----------AQP-LCEELCQAWFANCEDDITC- 132 human
Q4TUC0        65 GPGM-----VSEHCGKPSPGCESFLGHLQVALHNRFRLLLLgIRQ-----------AQP-LCSELCDIWFATCESDITC- 126 dog
Q0IHI5        63 -----ITSFPWGLCGPLSSSCEKYVSRVQCMYLCSPHISAF-WNQ----DSDTGIYNLP-LCSGFCNQWFEACKEDLICT 131 African clawed ...
Q14DK5        65 RFRVlETRMD----AGVWATCAGYALDLLC-QECSPYAAHL-YDAe---DPATPLRTVPgLCEDYCLDMWQTCRGLFRLL 135 house mouse
Q69GM1        88 DSKI-LS-------VANNTECAKLVEEIRCAH-CSPHAQNL-FHAsersETSERQLFLPvLCKDYCKEFYYTCRGQ---- 153 African clawed ...
4LRH_H       132 snwHKGWN----Wts-gfNKCAVGAAC---QPFHFy-fPTPTVLC--NEIWTHSYKVS--NYSRG--------------- 183 human
XP_006117388 136 hnwLTDWE----WdengeNHC--KNEC---ISYDKv-yANGTDLC--QSMWGDSFKVS-----DS--------------- 183
Q7T3I8       142 r----nWA----Rdp-rgQNC--TGNC---VQYQQm-yQHGRDLC--ESLWGDAFMTV--EDEPEevgeageigvdvdgv 202 Nile tilapia
Q5DRQ5       158 ---GRTWL----Wps-gkRSC--EGRC---RTYGQt-fADGVDLC--RSVLGHILPVA----APG--------------- 202 thirteen-lined ...
Q8QZY4       153 ---GPTWL----Qss-geRGC--EPSC---RTYGQt-fANATDLC--HSVLGHVLRVA----APG--------------- 197 house mouse
Q9BSG5       133 ---GPTWL----Pls-ekRGC--EPSC---LTYGQt-fADGTDLC--RSALGHALPVA----APG--------------- 177 human
Q4TUC0       127 ---GPTWL----Pll-ekRGC--EPRC---TTYEQt-fADGADLC--RSVLGYALPVA----APG--------------- 171 dog
Q0IHI5       132 ------------LtnetiPRC--ADAC---VPYKQmfkSEGEDLC--NGIWGDSLVAS-----SE--------------- 172 African clawed ...
Q14DK5       136 spdRELWA----LesnraKLC-------------RylsLDDTDYCfpSLLVNENLNSNlgRVVAD--------------- 183 house mouse
Q69GM1       154 ---IPGLLqtsaDefcfyHGMRDSGLCfpdFPRKQm-rGPASNYL--DQMEDYDKVEEisRKHKH--------------- 212 African clawed ...
4LRH_H       184 -SGRCIQ 189 human
XP_006117388 184 -SCLCLQ 189
Q7T3I8       203 rPCGCLT 209 Nile tilapia
Q5DRQ5       203 -SRHCLN 208 thirteen-lined ground squirrel
Q8QZY4       198 -SSHCLN 203 house mouse
Q9BSG5       178 -ARHCFN 183 human
Q4TUC0       172 -ADHCLN 177 dog
Q0IHI5       173 -NCACVN 178 African clawed frog
Q14DK5       184 -AKGCLQ 189 house mouse
Q69GM1       213 -NCYCIQ 218 African clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap