Conserved Protein Domain Family
DUF4657

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pfam15552: DUF4657 
Domain of unknown function (DUF4657)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.
Statistics
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PSSM-Id: 464762
Aligned: 16 rows
Threshold Bit Score: 383.036
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007476541  73 MGGGESPSTAPSSLALDSSNLALGGRPK-MASVTmE------PPPDLDRFLASRKLEQVVARSC----------WPRSSP 135
XP_004046807 146 MAVGDSPLAALPGLSQDSLDFESSGSP--------E------PPAQVGRLLASQKLGEVLERSR----------RLPTVP 201
EHB06020     207 MVAGDSTLATFPGLSQDSVSVEPMRSPEpTALAApE------PPSQLGQLLASRKLEQVLEWSQggahpstqhcALPPAP 280
Q66JV7        78 MVVGDSSLATLSGLSQDSLNLEPMGSPE-------L------PPAQLDRLLARQKLEEVLERSR----------EFP--- 131 house mouse
EGV91967      69 MVVGDSPLATLSGLSQDSLNLEPTGSPE-------L------PSVQLDRLRARRKLDQVLERSQ----------EFP--- 122
XP_005329370  77 MVVGDSPLATLSELSQDSLNLEPMGSPEh------LaldatePPAQLGRLLANHKLEQVLERSR----------QLP--- 137 thirteen-lined ...
XP_023371299   1 MAVGDSLLATLPGLSQDSLDFEPLGSP--------E------LPTQQGRFLASHKLEQMLERSH----------RLPTGP 56  small-eared galago
EFB26336      62 MVVGDSPLTPSPGLSQDSLDFEPAGSPVpLGLASlE------PAAHLGRLLASRKLEQVLERSR----------QLPTSP 125 giant panda
XP_006930705 114 MVVGDSPLATSPGLPQDSLDFEPTGSPdpralaamE------PPAHLSRLLANRKLEQVLERSR----------QLPTSP 177 domestic cat
XP_004763333 114 MVVGDGPLTTSPGLSQVCLDFEPTGSPEpLALAPvE------PPAHLGRLLANRKLEQVLERSR----------RLPTSP 177 domestic ferret
XP_007476541 136 ATLPKC-WQQ----REQGSEVSSEVTRDQNGTKAEpgsqagpaeslaL-GSEADAWACLPGQGLRYLEHLCLMLERMAML 209
XP_004046807 202 TSLSGQ-RHSlrlaTKPEREVPLFGAGEKESMEADtdleag-leeeaVgGLGPGAWACLPGQGLRYLEHLCLVLEQMARL 279
EHB06020     281 WT-------------RPGCAPPLLG--------AEakleqdleeaevVaAVVPRAWACLPGQGLRYLEHLCLVLEQMARL 339
Q66JV7       132 -SLSAQ-RGPlqllNKPVDGVPIF-AGEQESTEADteleagleeakeVgNMESAACTCLPGQGLRYLEHLCLVLEQMVRL 208 house mouse
EGV91967     123 -SLSGQrRHSlqllSKPVGGVPIF-AGELESTEAAtele----eakvVgDVESGALTCLPGQGLRYLEHLCLVLEQMARL 196
XP_005329370 138 -SVSGD-HGSl---SKPKCGVSLFGAGEQETTEAEtkleag-leaevVqgvDPGSWACLPGQGLRYLEHLCLVLEQMARL 211 thirteen-lined ...
XP_023371299  57 ASLSGR-RSPfqppSKPECEVPLYGAGKQESSEVHvdgeasleatevVeGPGPEAWTCLPGQGLRYLEHLCLVLEQMARL 135 small-eared galago
EFB26336     126 ASVSRY-PCSlkspREPECEMPLFGAGEQEAAKAEtaleagveeaevAgGLGPEAWACLPGQGLRYLEHLCLVLEQMARL 204 giant panda
XP_006930705 178 VGMSQH-HYSlkppIKPECEMPPFGAGEQEATEAEtdleaglegaevVgGLGPKAWACLPGQGLRYLEHLCLVLEQMARL 256 domestic cat
XP_004763333 178 ASMSRH-CSSlnspCEPERQVPPFGAGEQEATEAEtdleagleeaevAgALGPEAWACLPGQGLRYLEHLCLVLEQMARL 256 domestic ferret
XP_007476541 210 QQLQQQLQQQHQQ----------------------------M--------PTgtegT--NE------SS----------I 235
XP_004046807 280 QQLYLQLRIQRPP----------------------------G--------DP----G--KE------ES----------T 301
EHB06020     340 QQLYLQLRTQSPP----------------------------E--------DP----E--EE------EL----------A 361
Q66JV7       209 QQLYLQLQTQRPS----------------------------R--------DP----E--EE------------------V 228 house mouse
EGV91967     197 QQLYLQLQTQRPS----------------------------R--------DP----Q--EE------EL----------A 218
XP_005329370 212 QQLYLQLQTQRPL----------------------------G--------------SleEE------ES----------A 233 thirteen-lined ...
XP_023371299 136 QQLYLQLQSQRPP----------------------------G--------DP----E--EE------EL----------A 157 small-eared galago
EFB26336     205 QQLCLQLQTQRPPrdpeseeeeeegeppvapspppsrarghQ--------VH----E---Q------------------- 250 giant panda
XP_006930705 257 QQLYLQLQTQRPP----------------------------GaselqvgqDP----E--AVe----gEWgeqqqwppppA 298 domestic cat
XP_004763333 257 QQLYLQLQTQRPL----------------------------P--------DPev-eE--EEiegaggEP----------T 287 domestic ferret
XP_007476541 236 LAPYRPRVSS----VLgpqEFQRLVEKt-----gKVEESVLPRQAQMHSVSTPSLLEGPAGAAHTIPSYQGHRNNLSHWD 306
XP_004046807 302 RAPLPSPLYTpgngGQgpwELLSQTEQ-------TGAKAASPPKVEVPSANPPRLSETPVEPTYHLPSSQGHKRDISHWD 374
EHB06020     362 LAPLPSLLPApgsgVQgseELQSLTKE-------TGLEAASCSKVGMLSANPPRLPEAPVEPTDSFPPSQGHKQAPSHWD 434
Q66JV7       229 LAPALSSSHIpdnrVQehrEELSQTKDp------EGAEAASLPEVGVLVTSPSRLPEALLEPTHILPPSQEPK-DLSHWD 301 house mouse
EGV91967     219 LALS-SSSHSpdnrMQghkEQLSQTRDlgdvvlsEGAEAASLPEVGVLIANAPRLPEALLESTHTLPSSQGHKQDVSHWD 297
XP_005329370 234 LVPLPSPSPTpvngVQgtgELLSRTKE-------TGADAALSQKVGVLSINPPRLTEAPVEPTHSFLLSQEHKQDLSHWD 306 thirteen-lined ...
XP_023371299 158 VAPSPSPSQTssnqVQrpwELRSQTEE-------SGTKAASPPKVGMPNTSHPKLAEAPVEPTHNFPCSQGHK-DVSHWD 229 small-eared galago
EFB26336     251 -LSQMQGTGA---------------------------KPAAPLKVGPPGANPPRLLEATAEPAHIFPPSQGHKRDLSHWN 302 giant panda
XP_006930705 299 LDPSPPPSCApggeVQ---ELLSQTQE-------TGANTASPLKVGVPGANLPRLLEASAEPAHIFPSSQGHKRDLSHWN 368 domestic cat
XP_004763333 288 LAPSPPPSCDtgpeVH---ELLSQRQEa-------GAETAAPLKAGLPNANPPRLLEAAAEPAQIFAPSQGHKRDLSHWN 357 domestic ferret
XP_007476541 307 KVKALLNRIRWRSPRASEPSFAQDPPAPR--RDSKE-LPEGPLPCSSRRTFLPSLVSKKHRAKNFSV 370
XP_004046807 375 KVKVLLNRICRRSHHHPEPPAPPDGSDPR--IESRD-LPERPQCRPHRKTFMPSLVVKKQRAKNLSV 438
EHB06020     435 RVKVLLNRIRRRSPGHPKSLVPPDGSGPR--IESRD-LSESPQCHPQQNAFRPSLVVKKQ------- 491
Q66JV7       302 KVKVLLNRLRWRSPRLPEPPVPPDGSGSR--MEFRN-LSDRTPCHSQRKTFIPALVVKKPRAKNLSV 365 house mouse
EGV91967     298 KVKVLLNRIRWRSPRLPEPPAPPDGSGPR--MEFTN-LSERIQYHSHRKTFMPTLVVKKPRAKNLSV 361
XP_005329370 307 KVKVLLNRIRWRSSQHPEPPAPPNGSDPR--IETRD-LSERPQYHPHRKTFMPSLMVKKRRGKNLSV 370 thirteen-lined ground squirrel
XP_023371299 230 KVKVLLNRIRWRSHQQPEPPAPPGSSGLW--IEPRNhLPDRPQSCIHRKTFMPSLVVKKQRAKNLSV 294 small-eared galago
EFB26336     303 KVKVLLNRIRWRSPKHPDSPAPPDGLGAQprIESRG-VPERPPCQPLRKTFMPSFVVKKQRAKNLSV 368 giant panda
XP_006930705 369 KVKVLLNRIRWRSSKHSESSAPPDGPAPR--IESRG-VPERPPFQPLRKTFMPPFVVKKQRAKNLSV 432 domestic cat
XP_004763333 358 KVKVLLNRIRWRSPKHPESPALPDGPAPR--TESRG-VPERPPCQPLRKTFMPSFVVKKQRAKNLSV 421 domestic ferret
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