Conserved Protein Domain Family
DUF4594
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pfam15266: DUF4594 
Domain of unknown function (DUF4594)
This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.
Links
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Statistics
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PSSM-Id: 464604
Aligned: 20 rows
Threshold Bit Score: 131.436
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
VFV23292     138 PTRAKNRGAGGSPGGGLGRTPSMQMAVSSDSARK-G--AREPQSpGLVpGPVPhrpvggpqEVGWDYAQWKQEREQIDLA 214
EGW14853     127 TTQARTPRAKGTSGGGRGQSLPLQMTSSTDSSGK-G--VLDPRSpGTVpGPPPqqplglppeASWDYMQWKQEREQIDLA 203
A3KGF9       185 TTQARSPRAKGTSGGGRSWRAPLQMTSSSDSAGK-G--VLEPRSpGVVsSPPPqqslglspeASWDYTQWKQEREQIDLA 261 house mouse
XP_012401424 162 STKARSQRDESTLRGGSSLGSPMQIAITMEPGQK-A--V----GpGSQ-------------ELGRDYVRWKQEREQIDLA 221
XP_008115041 176 ITMDNKGRVDEKRPMERRWSEGDKHAVSGVIRKErG--KSPQKSpGDKsrt-------ltgRERSEYMRWKKEREQIDLE 246
XP_007492020 213 LQESERDRREGSRRHGRNWGGADFERVRSGLEQErY--GRRa---GPG---GDmtls-mtgRERAEYLRWKQERERIDQE 283
ELW71159     204 LEEPERDRREGSRRHGRNWGGPDFER------------GRRa---GLG-GAGDmtls-mtgRERSEYLRWKQERERIDQE 266
XP_010584770 205 LEEPERDRREGSRRHGRNWGGPDFERVRCGLEQErQ--GRRa---GLG-GAGDmtls-mtgRERSEYLRWKQEREKIDQE 277
XP_015196280 265 VPDADRDRKEGSRRHVRNWGGLDFDNVRTSPEWDkEwtSRRp---GPK-GSVDmtls-mtgRERAEYLRWKKEREQIDQE 339 spotted gar
XP_017918155 202 LEEPERDRREGSRRHGRNWGGPDFERVRYGLEQErQ--Grr---aGLR-GAGDmtls-mtgRERSEYLRWKQEREKIDQE 274 goat

VFV23292     215 RVARHRDAQGDWRRPWDLDKAKPTLQDSSK----PREEGPARAGg--TRGPRSHRKLQPPPLSPDGK--GgttRGGQPSR 286
EGW14853     204 RLARHRNAQGDWSRPWDLDKAKPMQQDCNK----QRDKDST-TG---RKGPRT-------PLSMDGK--R---RGGQSGR 263
A3KGF9       262 RLARHRNPQGDWSRPWDLDKAKSMPQNCHK----PRDRDLA-MGs--RKGPRTHQKPQHPPSSLDGK--C---RGGQSGR 329 house mouse
XP_012401424 222 RLARHRDAQGEWRRPWDLDKSKHMFQDASK----ARDLSISGGSs--KKGPRNYRKFQSRPLPPDERgsSa--HSGNLGK 293
XP_008115041 247 RLARHKNARGEWRRAWDVEKSDCMFEDT-------KDGGPALEGphsKKGGRNARKSQHRSLPSEGKvgGqhrRSTSESA 319
XP_007492020 284 RLQRHRKPTGQWRREWDAEKTEGMFKDGPS----TASEPPAHHDegsSR---------PPKPPTFGDflS-------QHK 343
ELW71159     267 RLQRHRKPTGQWRREWDAEKTDGMFKDGSThvhePFNEPSPRYDeqaWAR-----PPKPPKPPTFGEflS-------QHK 334
XP_010584770 278 RLQRHRKPTGQWRREWDAEKTDGMFKDGPA----PAVETSHRYDdqpWAR--------PPKPPTFGEflS-------QHK 338
XP_015196280 340 RLARHRNATGQWRREWDAQKADAMFKEDAA------VTGVP-TAdqgGRK---DDAKRPPKAPLLGDflS-------QAR 402 spotted gar
XP_017918155 275 RLQRHRKPTGQWRREWDAEKTDGmFKDGPA----VALEPSHRYDdqaWAR--------PPKPPTFREflS-------QHK 335 goat

VFV23292     287 SSVVSATRSKARGTERLTGRAR-------RWETKEGKEE 318
EGW14853     264 PSVTSTIGSKAQGKDRLTGRAR-------RYDMKEDEEL 295
A3KGF9       330 PSMTSTIGSNAQGKERLTGRAR-------RYDMKEDEML 361 house mouse
XP_012401424 294 PKV-PAMSSKARGKDRLTGRAR-------RWDTKEGEEQ 324
XP_008115041 320 SRTLPFMSSKAKGKDRLTGRAR-------RWDAKEGEEM 351
XP_007492020 344 TVPGNR-RRRKTSRPRVKGPPRgyshhddRWEPKEEVED 381
ELW71159     335 AEVSSR-RKRKSSRPQAKAAPRaysnhddRWEMKEETAS 372
XP_010584770 339 AEVNSR-RRRKSSRPQAKAVPHaysdhddRWETKETASL 376
XP_015196280 403 SKEPGRSRGRGKGR----AQGKsysmhddRWEDDKPEKE 437 spotted gar
XP_017918155 336 TEV-SR-RKKKSSRPQPKAAPRaysdhddRWETKEAVSA 372 goat
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