Conserved Protein Domain Family
MFS_MFSD9

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cd17390: MFS_MFSD9 
Major facilitator superfamily domain-containing protein 9
Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340948
Aligned: 20 rows
Threshold Bit Score: 311.853
Created: 14-Mar-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##  ##  #                               #                                
Q8NBP5     49 LYLVGFLDLFGVSMVVPLLSLHVkslgASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGrRSSLLACILLSALGYLLLga 128 human
EDO46735   18 LYLLGFLDLMTVSMGLPLAARRArelgATPSIVGLIGSVYGAIQFFSNPLVGKFSDVAGrKKVLLVSLLGTGAAYLLHgl 97  starlet sea anemone
EEZ97676   11 VYVLSFVDLFAVGLTVPLFSNHLrelgASHFTIGLLNSLYSGLQVISGPIVGSWSDVRDrRSVLQITLLLCSLGYVALgl 90  red flour beetle
JAS28949   20 LYILSFLDTFATSLIIPLLTIHFrslgMSHMLIGIISSVYAGVQLFSSPAIGCWSDKFGkQQTLKISLLICAVSYLILgv 99  Arizona spittle bug
KPI94738    8 LQFVAFLDLLAVGLIVPLVPNHIrqlgGNHIYVGLLGSIYSGFQLGSGPLIGSLSDLKGrRTILMFTLLLCAGVYSIMgf 87  Papilio xuthus
ODM98667   57 FYFMAFLDLLAVSLFLPLLSTGMrdlgATPFMTGLIGSAYGAIQLFSSPVMGWGSDIYGpKLVMFISLVATAVAYVVQgs 136 Orchesella cincta
JAS51107   12 VYTVSFLDFFGVSMILPVMSTHLrglgISYVDIGLLSSVYGMTQLIFGPIIGSLSDIQGrHTVLFLTTIVCSSVYGLMgi 91  Cuerna arida
ETW00839   21 LYLISFLDLFSVSLIVPSLPSYVkslgGDAVSIGYISSLYGAIQMVSAPLAGVLSDIFDrRLVLLIGIAGSAVGYVILgf 100 Aphanomyces invadans
GAQ82472   26 LLLLVFVDLMAAGMVMSMLVPLMkelgATPFQLGLISSTYGALQLTSGPMVGLLSDRKGrHFIIVAAYLGTAIGYGLVgf 105 Klebsormidium flac...
OIO86802    8 VIFVVFIDLLGFSLILPLLPYYAekygATQLVVGLLVASYAAMQLIGAPLLGRLSDRFGrRPILLASVGGTFLGFVLLgl 87  Anaerolineae bacte...
Feature 1                                        ## ###  #                   #  ##  #         
Q8NBP5    129 a------------------tnvFLFVLARVPAGIFKHTLSISRALLSDvvpeker-plvighFNTASGVGFILGPVVGGY 189 human
EDO46735   98 s------------------vslIMLALTRIPIGLFKQSQSLCKACLADitapaqr-isvfgkFNAFSSLGFVVGPLIGGH 158 starlet sea anemone
EEZ97676   91 t------------------nslLVIASVRILLGVTKHTQSICKAIITDlvppsdr-asafgrSTAFGSLGFIIGPTLGGH 151 red flour beetle
JAS28949  100 t------------------tsiFVIVVIRFILGIMKHTQTICKTLVPElftseqq-teafgmINAVTAIGFVAGPAVGGY 160 Arizona spittle bug
KPI94738   88 i------------------ssiAVILILRGMLGLFKQTQLLTKALVPDyesnqqkqsviygkMAAISGVGITLGPVIGGH 149 Papilio xuthus
ODM98667  137 a------------------lniAMMLVARGLAGIFKHTQTVGKSIVSElstkdk--shvignFNAFGSMGFILGPTLGAH 196 Orchesella cincta
JAS51107   92 i------------------ssfYLFLILNCILGAVQHTMMLCQAYIADivpvnkq-stvnglTNAFMSFSFMIGPIIGGH 152 Cuerna arida
ETW00839  101 s------------------mtlSMVVFSRVPCGVFKHTLSTVRLAVADqtstktr-adalgkINAYSSFGFIFGPLVGGI 161 Aphanomyces invadans
GAQ82472  106 s------------------rslEVLFLSRVITGLVRHSSNGVKAYISDrvsrser-svdfgrMATASGLGFMVGPMLGGF 166 Klebsormidium flac...
OIO86802   88 adpignalaksfspqsanlfvlAILFLSRIIDGLTGGNLSVAQAYISDvtdvqsr-skglglIGAAFGLGFIIGPATGGL 166 Anaerolineae bacte...
Feature 1                                                                                     
Q8NBP5    190 Ltele--dgfYLTAFICFLVFILNAGLVWFFPwreakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpw 267 human
EDO46735  159 Lamtd--ngfFRVFLLEGILFVAMTIFTWLCIehddqqqsspnkdvgtasess---------------------efdgar 215 starlet sea anemone
EEZ97676  152 Lierk--ngfFHVCLFTSVLFIINVGITCAINeikspkkrqlnhesvpifa--------------------------klg 203 red flour beetle
JAS28949  161 Fiete--ngfQLLCTISCLIFVFNTVIVYYFLrtveqvynikkes----------------------------------- 203 Arizona spittle bug
KPI94738  150 IvedhpengfMYIAIIVGFCFLVNAGLVYFLPatikktsketksksehesvm------------------------nkii 205 Papilio xuthus
ODM98667  197 Iaqld--kgfQIVCYISAAAFLFNAVLLAILVpdpsklmsskpspklspkskskkl----------------gskgdsde 258 Orchesella cincta
JAS51107  153 Vmeid--ggfQYLTAIVSLMLIFNSAIVFVFGnvnkiakkektknvsv-------------------------------f 199 Cuerna arida
ETW00839  162 Lgays--ngfNYTALLTAAVFIVNYALVFLYVppakpmvvasreiqcddptdidpmlldadr---dappvahnissiava 236 Aphanomyces invadans
GAQ82472  167 Lhry---ggqRLPGCLAALLFLCNATLASYFLpafpgptsdkggpespfpsplp-------------------prirswh 224 Klebsormidium flac...
OIO86802  167 Lsqw----gyAVPAFAASALSFINLLLIYFWLpesltaekraempdk--------------------------------- 209 Anaerolineae bacte...
Feature 1                             #  ##  ###  #                           #   #           
Q8NBP5    268 vevvlalrnmknllfSEMWDIFLVRLLMAMAVMLYYSNFVLaleerfgvrpkvTGYLISYSSMLGAVAGLALGPILRly- 346 human
EDO46735  216 nseiqtksgrklqenLKIANLLIVRFLMGFSMIIFRSNFSTvlefrynttpktNGYIMSFNGIVGGLSGYFVGNLLTfy- 294 starlet sea anemone
EEZ97676  204 hefnksvrdmgeidwGAFWDVFLLRFIFGFSVTMYFSQQSVylkeqfkmaqrhVGYTISFFSASGMAAAFLLHYINYfyk 283 red flour beetle
JAS28949  204 --vlsnlkelfsiewKLYWDVLILKLLLSLSMSLFYSNYALtieenfdvspkiIGYTNSFQSFVSAVSCLLSTKFLKiyy 281 Arizona spittle bug
KPI94738  206 tsskqsvvelskipwAEYWDVFLLKALISFAMAVYFSNYSLylktiyelspkyIGYVISIQGVISSVSSFFIGYINKfys 285 Papilio xuthus
ODM98667  259 vsrltklktsfknadIHSLILLAVRFLFSFATLVFRENLTItllekynsnlvnSGYLTSLQALMSTIMGFCVGPVNAfiy 338 Orchesella cincta
JAS51107  200 nqiirifkdllvidwKKYWVFFSLKFLFAMSGMLFFQNMGIiltdsfdltpryMGYTISFYGFISFISNLNVGRIKSlnl 279 Cuerna arida
ETW00839  237 vvdklsdykdilklsPIARSLLSVRLLMAASAILFRSHFMLlleekygassttRGYILSYMGGLAASSGLVVGRLVNlv- 315 Aphanomyces invadans
GAQ82472  225 arlesvlpqaavlrrPKVGALLAVRAVLGLAVQVFREGFTTlvlyrfeldarqNGMLISYQGFLTTLVQGFAIRPLVasy 304 Klebsormidium flac...
OIO86802  210 rapvtldallkalqrPFSGSLLITRFFFGLAFAIFQTMFAAyalqkfqltardTGFVLTYVGVLSVFVQGFLIGLLTka- 288 Anaerolineae bacte...
Feature 1                                              ##   #   #               #  ##  ##  #  
Q8NBP5    347 -khNSQALLLHSSILTCTLLLLYSlaptmgaVVLSSTLLSFSTAIGRTCITDLQLTVGGAqasGTLIGVGQSVTAVGRII 425 human
EDO46735  295 -nnDDAKALLHFSSILAMSIFCVTfspelwvLVVFIAPLAFSSAVSRVCSTNLTLKRGRAdekGLLLGVGNSLMSFARML 373 starlet sea anemone
EEZ97676  284 gdvSCLKRLTHFFLLMTLSLVCLYfapnielFLLVLVPFSLSCTVLRIVSMELMLKNASTthrGSLSGTSNSIMSVARFV 363 red flour beetle
JAS28949  282 tnkSYYLKLFHSFFILSLSFLCLGfvpnitiFVLCLVPLCTSSSLLRIMTTEVLLERAMPdqrGSLLGSENTIASIAYLI 361 Arizona spittle bug
KPI94738  286 ydtDYSVRNLHMFILVGVSLTGMIlatnvymFIVCLLPLAVGSAVGRLVSLEMVLTRCKGkhrGTLIGATNSVTSLSGVV 365 Papilio xuthus
ODM98667  339 -kgNSLYMVLITGILKTIVLFTLFwsssywlAGTMLVIVSALNPFLRVGITAVSLEGHHSd-iGTILGFSQSATSMARMI 416 Orchesella cincta
JAS51107  280 fpnNNYESLMYMFCVMAVTFYWLYivdncwlFLAGLVPLAASNALAEIVMTEVLVEQTDAssrGSMMGISASVAAIVQIF 359 Cuerna arida
ETW00839  316 --qSETLLVQGASIVYVLSFLGIAmatslpmVLALQAPQVIAISVLRACSVSLQTSAVAPeslGGIMGVSDSLTALARTA 393 Aphanomyces invadans
GAQ82472  305 -pkEGFLIQAGITSLGLAYVAASLgps-irsLVVLLAPVALAGGVVRTTFTALLTSAVPSsevGQLLGLADTLMSTCRVL 382 Klebsormidium flac...
OIO86802  289 --yREDVLITISVIVMAFALLGWAlapsvfwLIVVLTPTAISGGVLNTLLSSTLTKAVQPqeiGGILGFSASIESSTRIV 366 Anaerolineae bacte...
Feature 1                                          
Q8NBP5    426 APLLSGVaqe-vsPCGPPSLGAVLALVAIFIMSLNKR 461 human
EDO46735  374 SPTLGGLaqe-lsVYAPGMLSVSVSAVGILLMATRIV 409 starlet sea anemone
EEZ97676  364 TPVTSGLisdklgGSSALLFTAVPPLIGTLVSVWMKV 400 red flour beetle
JAS28949  362 GPSLSGFcrdqfgPICVSILSVLLTGIGATLSAILNS 398 Arizona spittle bug
KPI94738  366 APMVAGFigqyfgVAYGLYASLFATLLGVALSYQYRR 402 Papilio xuthus
ODM98667  417 SPTAAGLals-msTDGPFLLAAVSSICGIIATLAAQR 452 Orchesella cincta
JAS51107  360 APFLSGLiaswggVSSALKVSSLISATACFITLRKSR 396 Cuerna arida
ETW00839  394 GPLLSGYlyv-isSAGPAYGATALALASCVLFYATMV 429 Aphanomyces invadans
GAQ82472  383 GPTLAGLlvtrlgTTAPGFVSGMLVLLAGVLFRALGC 419 Klebsormidium flaccidum
OIO86802  367 APILGGVllqsvgAWTPGAFGAVVLTALSVYVWRVIY 403 Anaerolineae bacterium CG2_30_57_67

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