Conserved Protein Domain Family
DUF3446

?
pfam11928: DUF3446 
Early growth response N-terminal domain
Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.
Statistics
?
PSSM-Id: 463400
Aligned: 18 rows
Threshold Bit Score: 41.7462
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_008103208 118 GRFSLEPSGNN--GgpHPLWPEPLFSLVS-GLVGMANap----------tlPPLSSs--sSSSAPSSSSSSS--SSSPIl 180
P26632        99 GRFTLEPATNC--S--NSLWAEPLFSLVS-GLVGINPppasipsstsqathPSSSS----TSSIPSSSSSST--SSASL- 166 zebrafish
OWK12515     137 GRFSLEPAPNS--G--NTLWPEPLFSLVS-GLVSMTN--------------PPATSs---SASSPAASSSAS--QSPPL- 191
EOA99173      36 GRFSLEPAPNS--S--NTLWPEPLFSLVS-GLVGMAN--------------APPTSt--pSSSSPSSSS-----QSPPL- 88 
XP_003457055  81 GRFSFEPSVSTc-G--NNLWAESLLSL----LVGVAA--------------PPPASs--lPVSSPSVTSSSP--SQPTIs 135
CAF97249      89 GRFTFEPSTSVsgG--GGLWAEPLLSLFT-GLVSMAA--------------SPSTAssslSSVASSVASPAP--QSQPGf 149
XP_003223498  99 GKFCIDAQYPGgaGavGSYPADGILNLVSaGLLQGLAa-------------APTSS----SSSSSSSAA-----SSGSPg 156
BAF50737      34 GKFSIDPQYPG-----ASCYPEGIINIVSaGILQGVT--------------PPAST----TASSSVTSASPNplATGPLg 90 
XP_003976264  87 GKFAFDTPPSGgiGgsGWCSDNNIISLVSaGILGVS---------------PSPGT----VTTQTSSAA-----AAASM- 141
XP_015460567  66 GKISIDSQFAQ-----GSWTQEGLISLVCaDVEGKTT--------------ASSGTt--dLSGAPGSSQGP---EKAPL- 120
XP_008103208 181 lsasssSSSGQGSEAGPIYSAA---PTFpgPSSGsG-DLF-S--E---QPF---SGPQFPpPPAYPS 234
P26632       167 ------SCSVHQSEPNPIYSAA---PTY--SSAS-P-DIF-P--Es-gPNF---STTVGT-SLQYSS 212 zebrafish
OWK12515     192 ------SCAVQSNDSSPIYSAA---PTF--PTPN-T-DIF-P--EpqgQAF---PGSAGP-ALQYPP 238
EOA99173      89 ------SCSVQASENSPIYSAA---PTF--PNSS-S-DIF-P--EpqtQSF---PNPSGA-PMQYPP 135
XP_003457055 136 s----vQVTCSSAEITSVFSAI---PTY--TSAGaE-PLL-P------------ATDSQPaPLAFSP 179
CAF97249     150 aavpvsGCSASGASGL---------PAY--TSAA-G-PNF-L--PpvsISQ---PGLPGL-QPQGSP 196
XP_003223498 157 -------TMAPP-EMEHMYS-P---PPY----SScG-ELYhPhqQpqeGSYl--PAPSGH----FPP 200
BAF50737      91 vc---tmSQTQP-ELDHLYSPPpppPPY----SGcTgDLY-Q--Dp--SAFlspPPTTSTsSLAYQP 144
XP_003976264 142 --------GGQTSDMEQVYGPPl--PAY----STcS-DLY-Q--Dq--VSFh--HSPATStTLAYPG 186
XP_015460567 121 -----------SSAMEHMYTAP---PPY-----TcSaDVY-Q--Dp--SAYs--SATSCA--VAHPC 159
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap