"Transgenes" - Books

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Select item 18602421.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 14152802.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 43826723.

Genetically Engineered Crops: Experiences and Prospects.

National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Agriculture and Natural Resources; Committee on Genetically Engineered Crops: Past Experience and Future Prospects.

Washington (DC): National Academies Press (US); 2016 May 17.

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Select item 31441964.

Environmental Effects of Transgenic Plants: The Scope and Adequacy of Regulation.

National Research Council (US) Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants.

Washington (DC): National Academies Press (US); 2002.

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Select item 31466405.

Animal Biotechnology: Science-Based Concerns.

National Research Council (US) Committee on Defining Science-Based Concerns Associated with Products of Animal Biotechnology.

Washington (DC): National Academies Press (US); 2002.

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Select item 16686906.

Holland-Frei Cancer Medicine. 6th edition.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors.

Hamilton (ON): BC Decker; 2003.

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Select item 18669547.

C. elegans II. 2nd edition.

Riddle DL, Blumenthal T, Meyer BJ, et al., editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

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Select item 31393008.

Genetically Modified Pest-Protected Plants: Science and Regulation.

National Research Council (US) Committee on Genetically Modified Pest-Protected Plants.

Washington (DC): National Academies Press (US); 2000.

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Select item 31898349.

Self-Perpetuating Structural States in Biology, Disease, and Genetics.

National Academy of Sciences (US); Lindquist S, Henikoff S, editors.

Washington (DC): National Academies Press (US); 2002.

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Select item 165410610.

Immunobiology: The Immune System in Health and Disease. 5th edition.

Janeway CA Jr, Travers P, Walport M, et al.

New York: Garland Science; 2001.

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Select item 570487611.

Jasper's Basic Mechanisms of the Epilepsies. 5th edition.

Noebels JL, Avoli M, Rogawski MA, et al., editors.

New York: Oxford University Press; 2024.

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Select item 152013212.

Bioinformatics in Tropical Disease Research: A Practical and Case-Study Approach [Internet].

Gruber A, Durham AM, Huynh C, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2008.

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Select item 538535013.

Introduction to Epigenetics [Internet].

Paro R, Grossniklaus U, Santoro R, et al.

Cham (CH): Springer; 2021.

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Select item 219516214.

StemBook [Internet].

Cambridge (MA): Harvard Stem Cell Institute; 2008-.

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Select item 150279215.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.

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Select item 430428616.

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values.

Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct; Board on Life Sciences; Division on Earth and Life Studies; National Academies of Sciences, Engineering, and Medicine.

Washington (DC): National Academies Press (US); 2016 Jul 28.

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Select item 479834417.

Genome Editing in Neurosciences [Internet].

Jaenisch R, Zhang F, Gage F, editors.

Cham (CH): Springer; 2017.

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Select item 563261218.

Electromechanobiology of Cartilage and Osteoarthritis: A Tribute to Alan Grodzinsky on his 75th Birthday [Internet].

Connizzo BK, Han L, Sah RL, editors.

Cham (CH): Springer; 2023.

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Select item 314761419.

Genetically Engineered Organisms, Wildlife, and Habitat: A Workshop Summary.

National Research Council (US) Planning Committee for the Workshop on Research to Improve the Evaluation of the Impacts of Genetically Engineered Organisms on Terrestrial and Aquatic Wildlife and Habitats.

Washington (DC): National Academies Press (US); 2008.

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Select item 238715620.

Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

Noebels JL, Avoli M, Rogawski MA, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012.

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Figure 5Figure 5: Automated analyses of transcription factor gene expression.

(A-D) Representative frames showing expression of mCherry reporters for the indicated transcription factors (red) ovelayed on ubiquitous histone::gfp reporter expression marking all nuclei. Anterior is left. (E) Embryonic lineage trees showing expression of the indicated transcription factor::mCherry transgenes (colored), or a merged image showing expression of all four transgenes. This data was acquired and visualized using StarryNite and AceTree (Murray et al., 2008). Panels A-D were acquired from movies at http://epic.gs.washington.edu/. Panel E was adapted with permission from Murray et al., 2008.

Transcriptional regulation of gene expression in C. elegans.

WormBook: The Online Review of C. elegans Biology [Internet]. Pasadena (CA): WormBook; 2005-2018.
Fig. 6.2

Domain organization of DICERLIKE (DCL) proteins from various eukaryotes. DCL proteins are responsible for dicing dsRNAs of diverse origin, e.g., derived from transgenes, endogenous genes, or viruses, into siRNAs. They are also crucial for the biosynthesis of microRNAs (miRNAs), regulatory small RNAs produced from stem-loop structures formed by transcripts of endogenous loci. The RNase III domains are responsible for dicing, while other domains are involved in binding the target dsRNA. (From Johanson et al. 2013)

RNA-Based Mechanisms of Gene Silencing.

Paro R, Grossniklaus U, Santoro R, et al. Introduction to Epigenetics [Internet]. Cham (CH): Springer; 2021.
Figure 77–2.

Representative transgenes used in preclinical gene therapies for focal epilepsy, with putative mechanisms of action. Kv1.1 overexpression reduces neuronal excitability and shortens action potentials, thereby reducing neurotransmitter release. eGluCl detects extrasynaptic spillover of glutamate, opening a chloride conductance that hyperpolarizes and/or shunts excitatory currents. hM4Di, activated by an exogenous ligand such as olanzapine, opens presynaptic G protein–coupled inward-rectifying potassium channels, and also inhibits neurotransmitter release. NPY, acting through Y2 receptors, inhibits neurotransmitter release.

Gene Therapy for Refractory Epilepsy.

Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies. 5th edition. New York: Oxford University Press; 2024.
FIGURE A-6The generation of transgenic mice with randomly inserted transgenes. Embryos at the 4 to 8 cell stage are infected with retroviruses or DNA is injected into the male pronucleus of the zygote

The embryos can be transplanted into a foster mother. The exogenous DNA sequences are randomly integrated into the genome of the resulting transgenic mice directly or after incubation any time up until the blastocyst stage (~100 cells).

The Basic Science of Genome Editing.

National Academies of Sciences, Engineering, and Medicine; National Academy of Medicine; National Academy of Sciences; Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations. Human Genome Editing: Science, Ethics, and Governance. Washington (DC): National Academies Press (US); 2017 Feb 14.