"Saccharopolyspora" - Books

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Results: 8 books (12 items)

Select item 24632621.

Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats.

Washington (DC): National Academies Press (US); 2010.

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Select item 28787482.

The Science and Applications of Synthetic and Systems Biology: Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats.

Washington (DC): National Academies Press (US); 2011.

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Select item 30716683.

Microbial Ecology in States of Health and Disease: Workshop Summary.

Forum on Microbial Health; Board on Global Health; Institute of Medicine.

Washington (DC): National Academies Press (US); 2014 Feb 18.

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Select item 13709704.

Approved Lists of Bacterial Names (Amended).

Skerman VBD, McGowan V, Sneath PHA, editors.

Washington (DC): ASM Press; 1989.

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Select item 44036685.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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Select item 53153386.

Guidelines for drinking-water quality: Fourth edition incorporating the first and second addenda [Internet].

Geneva: World Health Organization; 2022.

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Select item 30771107.

Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary.

Chemical Sciences Roundtable; Board on Chemical Sciences and Technology; Division on Earth and Life Studies; National Research Council.

Washington (DC): National Academies Press (US); 2014 Jan 27.

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Select item 31010048.

Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary.

Committee on Science and Technology for Defense Warning; Division on Engineering and Physical Sciences; National Research Council.

Washington (DC): National Academies Press (US); 2013 May 15.

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FIGURE WO-32

Genomics can reveal cryptic natural products. Saccharopolyspora erythraea is a well-characterized bacterial species that is cultivated on an industrial scale to produce the potent antibiotic, erythromycin. Analysis of this bacterium's genome revealed a number of additional gene clusters that potentially encode as yet unknown natural products.
SOURCE: Adapted from Oliynk et al. (2007).

Workshop Overview.

Forum on Microbial Health; Board on Global Health; Institute of Medicine. Microbial Ecology in States of Health and Disease: Workshop Summary. Washington (DC): National Academies Press (US); 2014 Feb 18.
FIGURE A21-4Chemical production pathways are often encoded within gene clusters

The image is of an organelle containing 10–100 associated 2.5 MDa NRPS-PKS mega-complexes from B. subtilis (Straight et al., 2007). The erythromycin pathway is shown from Saccharopolyspora erythraea NRRL 2338 and echinomycin pathway from Streptomyces lasaliensis. For erythromycin, chemical groups added by post-assembly-line tailoring enzymes (two P450s and two glycosyltransferases) are shown in red. A, adenylation; T, thiolation; C, condensation; E, epimerization; MT, methyltransferase; TE, thioesterase; AT, acyltransferase; KS, ketosynthase; KR, ketoreductase; DH, dehydratase; ER, enoylreductase. Bacteriochlorophyll (bottom left) is incorporated into light harvesting complexes. FeMoCo (bottom right) is produced by a metabolic pathway and incorporated into nitrogenase (image from Noodleman et al. [2004]). All images reproduced with permission.

PROKARYOTIC GENE CLUSTERS: A RICH TOOLBOX FOR SYNTHETIC BIOLOGY.

Institute of Medicine (US) Forum on Microbial Threats. The Science and Applications of Synthetic and Systems Biology: Workshop Summary. Washington (DC): National Academies Press (US); 2011.