"Reassortant Viruses" - Books

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Results: 1 to 20 of 33 books (68 items)

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Select item 19408141.

The Threat of Pandemic Influenza: Are We Ready? Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats; Knobler SL, Mack A, Mahmoud A, et al., editors.

Washington (DC): National Academies Press (US); 2005.

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Select item 24211562.

The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions: Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats.

Washington (DC): National Academies Press (US); 2010.

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Select item 34132843.

Emerging Viral Diseases: The One Health Connection: Workshop Summary.

Forum on Microbial Threats; Board on Global Health; Institute of Medicine.

Washington (DC): National Academies Press (US); 2015 Mar 19.

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Select item 30328804.

Pandemic Influenza Preparedness and Response: A WHO Guidance Document.

Geneva: World Health Organization; 2009.

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Select item 46912125.

Biodefense in the Age of Synthetic Biology.

National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Life Sciences; Board on Chemical Sciences and Technology; Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology.

Washington (DC): National Academies Press (US); 2018 Jun 19.

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Select item 31039246.

Perspectives on Research with H5N1 Avian Influenza: Scientific Inquiry, Communication, Controversy: Summary of a Workshop.

Committee on Science, Technology, and Law; Policy and Global Affairs; Board on Life Sciences; Division on Earth and Life Studies; Forum on Microbial Threats; Board on Global Health; National Research Council; Institute of Medicine.

Washington (DC): National Academies Press (US); 2013 Apr 4.

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Select item 52186007.

Safety of Vaccines Used for Routine Immunization in the United States: An Update [Internet].

Gidengil C, Goetz MB, Maglione M, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Comparative Effectiveness Review, No. 244.)

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Select item 50832568.

FAQ: Influenza.

Washington (DC): American Society for Microbiology; 2013.

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Select item 44036689.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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Select item 233288610.

Infectious Disease Movement in a Borderless World: Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats.

Washington (DC): National Academies Press (US); 2010.

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Select item 445410811.

Dual Use Research of Concern in the Life Sciences: Current Issues and Controversies.

National Academies of Sciences, Engineering, and Medicine; Policy and Global Affairs; Committee on Science, Technology, and Law; Committee on Dual Use Research of Concern: Options for Future Management.

Washington (DC): National Academies Press (US); 2017 Sep 14.

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Select item 423423412.

Global Health Impacts of Vector-Borne Diseases: Workshop Summary.

Forum on Microbial Threats; Board on Global Health; Health and Medicine Division; National Academies of Sciences, Engineering, and Medicine.

Washington (DC): National Academies Press (US); 2016 Sep 21.

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Select item 310100413.

Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary.

Committee on Science and Technology for Defense Warning; Division on Engineering and Physical Sciences; National Research Council.

Washington (DC): National Academies Press (US); 2013 May 15.

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Select item 290025814.

Learning from SARS: Preparing for the Next Disease Outbreak: Workshop Summary.

Institute of Medicine (US) Forum on Microbial Threats; Knobler S, Mahmoud A, Lemon S, et al., editors.

Washington (DC): National Academies Press (US); 2004.

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Select item 317857015.

Respiratory Protection for Healthcare Workers in the Workplace Against Novel H1N1 Influenza A: A Letter Report.

Institute of Medicine (US) Committee on Respiratory Protection for Healthcare Workers in the Workplace Against Novel H1N1 Influenza A; Liverman CT, Harris TA, Rogers MEB, et al., editors.

Washington (DC): National Academies Press (US); 2009.

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Select item 315267216.

Emerging and Readily Available Technologies and National Security: A Framework for Addressing Ethical, Legal, and Societal Issues.

Committee on Ethical and Societal Implications of Advances in Militarily Significant Technologies that are Rapidly Changing and Increasingly Globally Accessible; Computer Science and Telecommunications Board; Board on Life Sciences; Committee on Science, Technology, and Law; Center for Engineering, Ethics, and Society; National Research Council; National Academy of Engineering; Chameau JL, Ballhaus WF, Lin HS, editors.

Washington (DC): National Academies Press (US); 2014 Mar 12.

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Select item 552252617.

Zoonoses the Ties that Bind Humans to Animals [Internet].

Vourc’h G, Moutou F, Morand S, et al.

Versailles (FR): Éditions Quae; 2022 Feb.

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Select item 536701818.

Emerging Threats of Synthetic Biology and Biotechnology: Addressing Security and Resilience Issues [Internet].

Trump BD, Florin MV, Perkins E, et al., editors.

Dordrecht (DE): Springer; 2021.

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Select item 530829219.

Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and Response: Lessons from COVID-19.

National Academy of Medicine; National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Global Health; Committee on Vaccine Research and Development Recommendations for Advancing Pandemic and Seasonal Influenza Preparedness and Response; Soltani H, Subbarao K, Bond E, editors.

Washington (DC): National Academies Press (US); 2021 Nov 17.

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Select item 479731420.

Exploring Lessons Learned from a Century of Outbreaks: Readiness for 2030: Proceedings of a Workshop.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Global Health; Forum on Microbial Threats; Nicholson A, Shah CM, Ogawa VA, editors.

Washington (DC): National Academies Press (US); 2019 May 8.

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Supplemental Content

Images search in Bookshelf

Figure 4

| Respiratory droplet transmission of H5 avian-human reassortant viruses in ferrets. a-f, Groups of three, five, or six ferrets were inoculated intranasally with 10⁶ p.f.u. of rgCA04 (a), rgVN1203/CA04 (b), rg(N224K/Q226L)/CA04 (c), HA(N158D/N224K/Q226L)/CA04 (d), HA(N158D/N224K/Q226L/T318I)/CA04 (e), or rgT318I/CA04 (f). One day after infection, three, five, or six naive ferrets were placed in adjacent cages. Nasal washes were collected every other day from both inoculated (left panel) and contact (right panel) animals for virus titration. Virus titres in organs were determined by using a plaque assay on MDCK cells. The lower limit of detection is indicated by the horizontal dashed line.

The Two Published H5N1 Papers.

Committee on Science, Technology, and Law; Policy and Global Affairs; Board on Life Sciences; Division on Earth and Life Studies; Forum on Microbial Threats; Board on Global Health; National Research Council; Institute of Medicine. Perspectives on Research with H5N1 Avian Influenza: Scientific Inquiry, Communication, Controversy: Summary of a Workshop. Washington (DC): National Academies Press (US); 2013 Apr 4.
Figure 1

| Localization of amino acid changes identified in this study on the three-dimensional structure of the monomer of VN1203 HA (Protein Data Bank accession 2FK0)¹⁵. a, Close-up view of the globular head of VN1203 HA. Mutations known to increase affinity to human-type receptors are shown in blue. Amino acid changes not previously known to affect receptor binding are shown in green. Additional mutations that occurred in the HA of H5 avian-human reassortant viruses during replication and/or transmission in ferrets are shown in red.b, The positions of four mutations in the HA of H5 transmissible reassortant mutant virus, HA(N158D/N224K/Q226L/T318I)/CA04, are highlighted in red. The fusion peptide of HA is shown in cyan. All mutations are shown with H3 numbering. Images were created with MacPymol (http://www.pymol.org/).

The Two Published H5N1 Papers.

Committee on Science, Technology, and Law; Policy and Global Affairs; Board on Life Sciences; Division on Earth and Life Studies; Forum on Microbial Threats; Board on Global Health; National Research Council; Institute of Medicine. Perspectives on Research with H5N1 Avian Influenza: Scientific Inquiry, Communication, Controversy: Summary of a Workshop. Washington (DC): National Academies Press (US); 2013 Apr 4.
Figure 7

| Pathological analyses of H5 avian-human reassortant viruses. a, Representative histological changes in nasal turbinates from influenza-virus-infected ferrets. Three ferrets per group were infected intranasally with 10⁶p.f.u. of virus, and tissues were collected on day 3 after infection for pathological examination. Uninfected ferret tissues served as negative controls (normal). Left panel, haematoxylin-and-eosin staining. Right panel, immunohistochemical staining for viral antigen detection (brown staining). Scale bars, 50 μm. b, Pathological severity scores in infected ferrets. To represent comprehensive histological changes, respiratory tissue slides were evaluated by scoring the pathological changes and viral antigen expression levels. The pathological scores were determined for each animal in each group (n = 3 per group on days 3 and 6 after infection) using the following scoring system: 0, no pathological change/antigen negative; 1, affected area (<30%) or only interstitial lesion/rare viral antigens; 2, affected area (<80%, ≥30%)/moderate viral antigens; 3, severe lesion (≥80%)/many viral antigens. Nasal, pathological changes in the nasal mucosa; nasal Ag, viral antigens in the nasal mucosa. Asterisks indicate virus pathological scores significantly different from that of rgCA04 (Dunnett's test; P < 0.05). Error bars denote standard deviation.

The Two Published H5N1 Papers.

Committee on Science, Technology, and Law; Policy and Global Affairs; Board on Life Sciences; Division on Earth and Life Studies; Forum on Microbial Threats; Board on Global Health; National Research Council; Institute of Medicine. Perspectives on Research with H5N1 Avian Influenza: Scientific Inquiry, Communication, Controversy: Summary of a Workshop. Washington (DC): National Academies Press (US); 2013 Apr 4.