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Select item 32564481.

Review of the Fialuridine (FIAU) Clinical Trials.

Institute of Medicine (US) Committee to Review the Fialuridine (FIAU/FIAC) Clinical Trials; Manning FJ, Swartz M, editors.

Washington (DC): National Academies Press (US); 1995.

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Select item 33081682.

Sofosbuvir (Sovaldi): Sofosbuvir is Indicated for the Treatment of Chronic Hepatitis C Virus (CHC) Infection in Adult Patients With Compensated Liver Disease, Including Cirrhosis [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Oct.

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Select item 42618023.

Ledipasvir/Sofosbuvir (Harvoni): For the Treatment of Chronic Hepatitis C Virus (CHC) G1 Infection in Adults [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 42179904.

Riociguat (Adempas): Management of Inoperable Chronic Thromboembolic Pulmonary Hypertension [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 44957345.

5-Fluorouracil 0.5% and Salicylic Acid 10.0% (Actikerall) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr.

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Select item 42165846.

Macitentan (Opsumit): For Long-Term Treatment of Pulmonary Arterial Hypertension [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 43661967.

Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (EVG/COBI/FTC/TAF) (Genvoya) Fixed-Dose Combination, Oral Tablet) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Nov.

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Select item 47403088.

Clinical Review Report: Riociguat (Adempas) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Dec.

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Select item 47498589.

Clinical Review Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/FTC/TAF) (Biktarvy): (Gilead Sciences Canada, Inc.): Indication: A complete regimen for the treatment of HIV-1 infection in adults with no known substitution associated with resistance to the individual components of Biktarvy [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Oct.

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Select item 476163410.

Common Drug Review New Combination Product Submission: Darunavir/Cobicistat/Emtricitabine/Tenofovir alafenamide (Symtuza): (Janssen Canada Inc.): Indication: A complete regimen for the treatment of HIV type 1 infection in adults and adolescents (aged 12 years and older with body weight at least 40 kg) with no known mutations associated with resistance to the individual components of Symtuza [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Aug.

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Select item 513743411.

Clinical Review Report: Cabotegravir Tablets, Cabotegravir Extended-Release Injectable Suspension, and Rilpivirine Extended-Release Injectable Suspension (Vocabria, Cabenuva): (ViiV Healthcare ULC): Indication: HIV-1 infection [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2020 Sep.

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Select item 498122812.

NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3′-Azido-3′-deoxythymidine (AZT) and Clarithromycin Combinations (CAS Nos. 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss CD-1® Mice [Internet].

Rao GN, Giles HD, Rogers TS, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2003 Oct. (Toxicity Report, No. 9.)

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Select item 265918213.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 498301814.

NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3′-Azido-3′-deoxythymidine (AZT) and Pyrazinamide Combinations (CAS Nos. 30516-87-1 and 98-96-4) Administered by Gavage to Swiss CD-1® Mice [Internet].

Rao GN, Giles HD, Heath JE, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2002 Apr. (Toxicity Report, No. 7.)

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Select item 498100215.

NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3’-Azido-3’-deoxythymidine (AZT), Trimethoprim (TMP)/Sulfamethoxazole (SMX), and Folinic Acid Combinations Administered by Gavage to Swiss (CD-1®) Mice [Internet].

Rao GN, Cirvello JD, Rogers TR, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 1998 Dec. (Toxicity Report, No. 2.)

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Select item 466351616.

Clinical Review Report: Sofosbuvir / Velpatasvir / Voxilaprevir (Vosevi): (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6 [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb.

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Select item 498111817.

NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Study of 3′-Azido-3′-deoxythymidine (AZT) and Rifabutin Combinations (CAS Nos. 30516-87-1 and 7255-06-09) Administered by Gavage to Swiss (CD-1®) Mice [Internet].

Rao GN, Collins BJ, Giles HD, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2000 May. (Toxicity Report, No. 4.)

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Select item 498135618.

NIEHS Technical Report on the Subchronic Toxicity Study of 3′-Azido-3′-deoxythymidine (AZT) and Rifampicin Combinations (CAS Nos. 30516-87-1 and 13292-46-1) Administered by Gavage to B6C3F1 Mice [Internet].

Rao GN, Farnell DR, Giles HD, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2001 Jan. (Toxicity Report, No. 6.)

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Select item 466487419.

Pharmacoeconomic Review Report: Sofosbuvir/Velpatasvir/Voxilaprevir (Vosevi): (Gilead Sciences Canada, Inc.): Indication: Hepatitis C infection genotype 1 to 6 [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Feb.

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Select item 498181420.

NIEHS Technical Report on the 13-Week Toxicity Study of 3′-Azido-3′-deoxythymidine (AZT) and Isoniazid Combinations (CAS Nos. 30516-87-1 and 54-85-3) Administered by Gavage to B6C3F1 Mice [Internet].

Rao GN, Giles HD, Lindamood C III, et al.

Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2002 Jul. (Toxicity Report, No. 8.)

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Figure 13

Purine-pyrimidine landscape representation (excess of purines over pyrimidines) of the human beta globin chromosomal region (GenBank accession HUMHBB) of the total length L = 73,308. The overall frequency of purines (50.27%) is almost equal to the frequency of pyrimidines (49.73%). HUMHBB contains a KpnI repeat from position 67071 to position 73195. This region is very purine rich with 58.57% of purines. KpnI repeat belongs to the LINE1 family of repetitive elements. A region from 23,137 to 29,515 is very purine poor (41.43%). It contains 3 segments of LINE1 repetitive elements inserted into the opposite DNA strand, so that all purines are exchanged with pyrimidines.

Power Law Correlations in DNA Sequences.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 3

Models of evolution represent rate changes along the arrows changing a nucleotide from one to another. Often these rates are different and there is often a difference between transitions (changes within pyrimidines or purines) and transversions (changes among class).

Phylogenomics and Molecular Evolution of Polyomaviruses.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 47.3

Metabolic activation and targets of fluorinated pyrimidines. DT = thymidine (thymine deoxyriboside); MP, DP, TP = mono-, di-, and triphosphate; dTMP also called thymidylate; dU = deoxyuridine; FdU = fluorodeoxyuridine; dUMP and FdUMP also called deoxyuridylate and fluorodeoxyuridylate; FBAL = fluoro-ß-alanine; FU = fluorouracil; FUMP also called fluorouridylate; O = orotidine; U = uridine (uracil riboside); OMP also called orotidylate; UMP also called uridylate.

Pyrimidine and Purine Antimetabolites.

Bast RC Jr, Kufe DW, Pollock RE, et al., editors. Holland-Frei Cancer Medicine. 5th edition. Hamilton (ON): BC Decker; 2000.
Figure 50-3

Metabolic activation and targets of fluorinated pyrimidines. CO₂ = carbon dioxide; dT = thymidine (thymine deoxyriboside); dTMP also called thymidylate; dU = deoxyuridine; dUMP = deoxyuridine monophosphate; FBAL = fluoro-β-alanine; FdU = fluorodeoxyuridine; FdUMP = fluorodeoxyuridine monophosphate; 5-FU = fluorouracil; 5-FUMP = 5-fluorouridine monophosphate (also called fluorouridylate); MP, DP, TP = mono-, di-, and triphosphate; NH₃ = ammonia; O = orotidine; OMP also called orotidylate; PRPP = phosphoribosyl pyrophosphate; U = uridine (uracil riboside); UMP also called uridylate.

Pyrimidine Analogs.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003.