"Polymorphism, Restriction Fragment Length" - Books

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Human Papillomaviruses.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2007. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 90.)

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Helicobacter pylori: Physiology and Genetics.

Mobley HLT, Mendz GL, Hazell SL, editors.

Washington (DC): ASM Press; 2001.

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Select item 29807923.

Chromosomal Variation in Man: A Catalog of Chromosomal Variants and Anomalies: Online NLM Version [Internet].

Borgaonkar DS.

Bethesda (MD): National Center for Biotechnology Information (US); 1975-.

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Select item 32658144.

DNA Technology in Forensic Science.

National Research Council (US) Committee on DNA Technology in Forensic Science.

Washington (DC): National Academies Press (US); 1992.

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Select item 44036685.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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Holland-Frei Cancer Medicine. 6th edition.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors.

Hamilton (ON): BC Decker; 2003.

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Select item 26591827.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 18602428.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 32230529.

Ending Neglect: The Elimination of Tuberculosis in the United States.

Institute of Medicine (US) Committee on the Elimination of Tuberculosis in the United States; Geiter L, editor.

Washington (DC): National Academies Press (US); 2000.

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Select item 141528010.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 340129411.

Endotext [Internet].

Feingold KR, Ahmed SF, Anawalt B, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment [Internet].

Dahabreh IJ, Moorthy D, Lamont JL, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Sep. (Comparative Effectiveness Reviews, No. 125.)

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The Evaluation of Forensic DNA Evidence.

National Research Council (US) Committee on DNA Forensic Science: An Update.

Washington (DC): National Academies Press (US); 1996.

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Mapping and Sequencing the Human Genome.

National Research Council (US) Committee on Mapping and Sequencing the Human Genome.

Washington (DC): National Academies Press (US); 1988.

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Select item 145898415.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2025.

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Select item 437626416.

Human Immunodeficiency Viruses and Human T-Cell Lymphotropic Viruses.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1996. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 67.)

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Select item 158168617.

Medical Microbiology. 4th edition.

Baron S, editor.

Galveston (TX): University of Texas Medical Branch at Galveston; 1996.

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Genomes. 2nd edition.

Brown TA.

Oxford: Wiley-Liss; 2002.

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Personal Habits and Indoor Combustions.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100E.)

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Bioinformatics in Tropical Disease Research: A Practical and Case-Study Approach [Internet].

Gruber A, Durham AM, Huynh C, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2008.

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FIGURE 1-2

Basis of restriction fragment length polymorphism (RFLP). Diagram indicates heterozygosity at a "restriction site": chromosome on left has sequence CCGG that is recognized and cut by specific restriction enzyme, whereas chromosome on right has one-nucleotide difference that results in sequence CTGG, which is not recognized and cut by enzyme.

Introduction.

National Research Council (US) Committee on DNA Technology in Forensic Science. DNA Technology in Forensic Science. Washington (DC): National Academies Press (US); 1992.
Figure 5.4A restriction fragment length polymorphism (RFLP)

The DNA molecule on the left has a polymorphic restriction site (marked with the asterisk) that is not present in the molecule on the right. The RFLP is revealed after treatment with the restriction enzyme because one of the molecules is cut into four fragments whereas the other is cut into three fragments.

Mapping Genomes.

Brown TA. Genomes. 2nd edition. Oxford: Wiley-Liss; 2002.
Figure 4.29A restriction fragment length polymorphism (RFLP)

The region of DNA shown contains three cleavage sites for BamHI in molecule I. In molecule II one of these sites has mutated from A to G, so it is no longer recognized by the restriction endonuclease. This mutation generates an RFLP, which can be detected by Southern blot hybridization of BamHI-digested DNAs with a probe derived from the polymorphic region. In DNA I, the probe hybridizes to a 4-kb BamHI fragment. In DNA II, however, the probe hybridizes to a 9-kb BamHI fragment instead, because one of the BamHI sites has been lost.

The Human Genome.

Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000.
Figure 7-14Some DNA sequence changes that produce a restriction fragment length polymorphism (RFLP)

(A) In many individuals in the population, a restriction nuclease cuts the chromosomal DNA shown at three sites, producing two DNA fragments; one of these DNA fragments is detected with a labeled DNA probe after gel electrophoresis and Southern blotting. (B) In other examples of the same chromosome, a single base-pair change in the short sequence recognized by the restriction nuclease prevents cutting at the central restriction site. The labeled probe now detects a much longer DNA fragment as an RFLP. (C) In yet other examples of the same chromosome, a sequence duplication increases the length of the DNA fragment that is detected by the labeled probe. This type of RFLP is commonly found in regions containing runs of short repeated sequences, such as GTGTGT...; the number of such tandem repeats is found to be highly variable in the population, with each individual typically containing a different number of copies (generally 4 to 40) of the repeat at each particular locus. A repeat of this type is commonly referred to as either a microsatelliteor a VNTR (variable number of tandem repeat) sequence.

Nucleic Acid Hybridization .

Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.