"Myositis, Inclusion Body" - Books

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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2026 Jan-.

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Select item 43014062.

Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis.

O’Connor J, McCaughan D, McDaid C, et al.

Southampton (UK): NIHR Journals Library; 2016 Jul. (Health Technology Assessment, No. 20.55.)

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Select item 14589843.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 14152804.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 53827725.

Skills in Rheumatology [Internet].

Almoallim H, Cheikh M, editors.

Singapore: Springer; 2021.

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Select item 55010026.

Alternative Therapies to Immunoglobulin for Idiopathic Inflammatory Myopathies: CADTH Health Technology Review [Internet].

Subramonian A, Brett K, Severn M; Authors.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2023 Jun.

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Select item 51939467.

Musculoskeletal Diseases 2021-2024: Diagnostic Imaging [Internet].

Hodler J, Kubik-Huch RA, von Schulthess GK, editors.

Cham (CH): Springer; 2021.

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Select item 53703308.

Selected Immune Disorders and Disability.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Care Services; Committee on Selected Immune Disorders and Disability.

Washington (DC): National Academies Press (US); 2022 May 24.

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Select item 55766649.

Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT.

Maher TM, Tudor VA, Saunders P, et al.

Southampton (UK): National Institute for Health and Care Research; 2024 Feb. (Efficacy and Mechanism Evaluation, No. 11.04.)

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Select item 462955610.

Off-Label Use of Intravenous Immunoglobulin for Neurological Conditions: A Review of Clinical Effectiveness [Internet].

Sutton D, Visintini S.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Mar 14.

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Select item 463004611.

Off-Label Use of Intravenous Immunoglobulin for Autoimmune or Inflammatory Conditions: A Review of Clinical Effectiveness [Internet].

Peprah K, Adcock L.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Apr 6.

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Select item 309735012.

Safe and Effective Medicines for Children: Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act.

Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA); Board on Health Sciences Policy; Institute of Medicine; Field MJ, Boat TF, editors.

Washington (DC): National Academies Press (US); 2012 Feb 29.

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Select item 523768613.

Amyotrophic Lateral Sclerosis [Internet].

Araki T, editor.

Brisbane (AU): Exon Publications; 2021 Jul 25.

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Select item 532506814.

Enhancing NIH Research on Autoimmune Disease.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee for the Assessment of NIH Research on Autoimmune Diseases.

Washington (DC): National Academies Press (US); 2022 Jun 2.

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Select item 577811415.

Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis.

Imamura M, Robertson C, Hudson J, et al.

Southampton (UK): National Institute for Health and Care Research; 2025 May. (Health Technology Assessment, No. 29.20.)

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Select item 567236816.

An Inventory of Rare Disease Registries in the Canadian Landscape: Environmental Scan [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2024 Aug.

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Select item 186024217.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 521860018.

Safety of Vaccines Used for Routine Immunization in the United States: An Update [Internet].

Gidengil C, Goetz MB, Maglione M, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2021 May. (Comparative Effectiveness Review, No. 244.)

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Select item 551740019.

Anifrolumab (Saphnelo): CADTH Reimbursement Review: Therapeutic area: Systemic lupus erythematosus [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2023 Apr.

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Select item 226248020.

Safety of Silicone Breast Implants.

Institute of Medicine (US) Committee on the Safety of Silicone Breast Implants; Bondurant S, Ernster V, Herdman R, editors.

Washington (DC): National Academies Press (US); 1999.

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Fig. 17.9

Axial T1 MR image of the left lower leg in an 82-year-old male demonstrates profound isolated fatty infiltration of the medial head of the gastrocnemius muscle (black arrow). This pattern when symmetric is in keeping with chronic changes of inclusion body myositis

Muscle Imaging.

Hodler J, Kubik-Huch RA, von Schulthess GK, editors. Musculoskeletal Diseases 2021-2024: Diagnostic Imaging [Internet]. Cham (CH): Springer; 2021.
Fig. 17.10

Axial fat-saturated STIR MR image of the left thigh in a patient with inclusion body myositis and acute pain. Notice the diffuse edema in the anterior compartment musculature (black arrow) with notable sparing of the rectus femoris (white arrow)

Muscle Imaging.

Hodler J, Kubik-Huch RA, von Schulthess GK, editors. Musculoskeletal Diseases 2021-2024: Diagnostic Imaging [Internet]. Cham (CH): Springer; 2021.
Figure 2

Inclusion body myositis (IBM): a) rimmed vacuoles can be observed (hematoxylin-eosin staining); b) a mononuclear cell infiltrate, mainly composed by CD8,⁺ T lymphocytes, surrounds a nonnecrotic muscle fiber. e) Modified Gomori trichrome staining shows typical vacuoles with basophilic red granular material in the muscle cell cytoplasm. Electron microscopy (EM) analysis demonstrates the presence (within muscle fibers) of c) cytoplasmic twisted tubulofilaments and d) amyloid-like fibrils. As for the other IIM forms, the activating factor is unknown. It has been proposed that factors, related to muscle aging or to environment (for sporadic-IBM) or of genetic origin (for hereditary-IBM), lead to a defect in the protein processing machinery that in turn causes abnormal protein accumulation within muscle fibers. This accumulation might lead to oxidative stress and other alterations, responsible for muscle fiber degeneration and death.

Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 3

The histopathological features of dermatomyositis (DM) muscle biopsy are shown. A still unknown triggering factor activates CD4⁺ T lymphocytes, which in turn might provide help to B cells to produce antibodies. The antibodies activate the complement cascade that ends with membranolytic attack complex (MAC) deposition on capillaries. This induces capillary depletion (capillaries are stained with fluorescent Ulex europaeus agglutinin lectin) and eventually perifascicular atrophy (outlined as intense NADH-stained fibers), due to the endofascicular hypoperfusion of muscle tissue. Muscle fibers are positive for major histocompatibility complex (MHC) class I molecule expression.

Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.