"Methyltransferases" - Books

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Select item 14152801.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 14589842.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 18602423.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 44036684.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2026 Jan-.

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Select item 26591825.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 21951626.

StemBook [Internet].

Cambridge (MA): Harvard Stem Cell Institute; 2008-.

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Select item 31898347.

Self-Perpetuating Structural States in Biology, Disease, and Genetics.

National Academy of Sciences (US); Lindquist S, Henikoff S, editors.

Washington (DC): National Academies Press (US); 2002.

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Select item 56831068.

World Cancer Report: Cancer research for cancer prevention.

Wild CP, Weiderpass E, Stewart BW, editors.

Lyon (FR): International Agency for Research on Cancer; 2020.

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Select item 14416189.

Helicobacter pylori: Physiology and Genetics.

Mobley HLT, Mendz GL, Hazell SL, editors.

Washington (DC): ASM Press; 2001.

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Select item 485381610.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 538535011.

Introduction to Epigenetics [Internet].

Paro R, Grossniklaus U, Santoro R, et al.

Cham (CH): Springer; 2021.

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Select item 323569012.

Arsenic in Drinking Water.

National Research Council (US) Subcommittee on Arsenic in Drinking Water.

Washington (DC): National Academies Press (US); 1999.

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Select item 532167213.

Essentials of Glycobiology [Internet]. 4th edition.

Varki A, Cummings RD, Esko JD, et al., editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.

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Select item 550803814.

RNA, the Epicenter of Genetic Information: A new understanding of molecular biology.

Mattick J, Amaral P.

Abingdon (UK): CRC Press; 2022 Sep 20.

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Select item 188138215.

Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition.

Siegel GJ, Agranoff BW, Albers RW, et al., editors.

Philadelphia: Lippincott-Raven; 1999.

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Select item 282062216.

Medical Genetics Summaries [Internet].

Pratt VM, Scott SA, Pirmohamed M, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

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Select item 186900817.

Sequence - Evolution - Function: Computational Approaches in Comparative Genomics.

Koonin EV, Galperin MY.

Boston: Kluwer Academic; 2003.

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Select item 464581018.

Signaling Mechanisms Regulating T Cell Diversity and Function.

Soboloff J, Kappes DJ, editors.

Boca Raton (FL): CRC Press/Taylor & Francis; 2018.

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Select item 244051419.

Maternal Control of Development in Vertebrates: My Mother Made Me Do It!

Marlow FL.

San Rafael (CA): Morgan & Claypool Life Sciences; 2010.

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Select item 500888420.

The Pangenome: Diversity, Dynamics and Evolution of Genomes [Internet].

Tettelin H, Medini D, editors.

Cham (CH): Springer; 2020.

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Supplemental Content

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Fig. 9.5

S-adenosylmethionine (SAM) is the cofactor of DNA and histone methyltransferases. SAM and S-adenosylhomocystein (SAH) are shown. SAM is the cofactor for DNA methyltransferase and histone methyltransferase. The methyl group of SAM serves as donor for trans-methyltransferase reactions. SAM is then converted into SAH, which is a potent inhibitor of all methyltransferases

Epigenetics and Metabolism.

Paro R, Grossniklaus U, Santoro R, et al. Introduction to Epigenetics [Internet]. Cham (CH): Springer; 2021.
Fig. 8.4

DNA methyltransferase inhibitors. Chemical structure of cytidine nucleoside and DNA methyltransferases inhibitors azanucleosides

Epigenetics and Cancer.

Paro R, Grossniklaus U, Santoro R, et al. Introduction to Epigenetics [Internet]. Cham (CH): Springer; 2021.
Figure 11.4

Regulation of CD4⁺ T cell differentiation by histone methyltransferases. Histone methyltransferases are critical regulators of CD4⁺T cell-associated transcription factors and effector cytokines. (a) The role of Ezh2 in regulating Tbx21 remains controversial. Interaction of this HMT with the Tbx21 regulatory region may promote or suppress expression of T-bet. SUV39H1 mediates the suppression T_H1 transcription factors in T_H2 cells and vice versa through H3K9me3 modifications. HP1a forms a complex with SUV39H1 to further suppress the T_H1 phenotype and stabilize the T_H2 phenotype in T_H2 cells. MLL1 has been shown to interact with key T_H2 transcription factors, Gata3, and other components to form a multisubunit complex capable of inducing IL-4 production through interaction with the Gata3 promoter. (b) Ezh2 actively suppresses T_H2 cytokine production in T_H1 cells through deposition of H3K27me2 at the IL4 and Il13 locus of T_H1, but not T_H2 cells. SUV39H1 mediates the suppression T_H1-associated Ifng in T_H2 cells and T_H2-associated Ifl4 in T_H1 through H3K9me3 modifications. Finally, G9a is important for restraining IL-17 production through deposition of H3K9me2 modifications.

Histone Methyltransferases and T Cell Heterogeneity.

Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018.
Figure 3

Histone methyltransferases and demethylases function antagonistically to control gene expression patterns during ES cell differentiation. In pluripotent cells, the essential pluripotency gene Oct4 is maintained in an active state by the histone H3 K9 demethylases Jmjd1a and Jmjdc2 whose expression is in turn regulated by Oct4 to maintain self-renewal. Upon differentiation, G9a tri-methylates histone H3 lysine 9 in the promoter region of Oct4 which results in recruitment of HP1 and DNA methyltransferases, leading to stable gene repression and exit from pluripotency.

The chromatin signature of pluripotent cells.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.