"Iduronate Sulfatase" - Books

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See ARSH (SULFATASE) arylsulfatase family member H in the Gene database

sulfatase in Homo sapiens Musca domestica Aedes aegypti All 5 Gene records

Results: 13 books (59 items)

Select item 14589841.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2024.

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Select item 44036682.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Select item 14152803.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 16492744.

Fabry Disease: Perspectives from 5 Years of FOS.

Mehta A, Beck M, Sunder-Plassmann G, editors.

Oxford: Oxford PharmaGenesis; 2006.

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Select item 18690085.

Sequence - Evolution - Function: Computational Approaches in Comparative Genomics.

Koonin EV, Galperin MY.

Boston: Kluwer Academic; 2003.

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Select item 30111826.

Enzyme-Replacement Therapies for Lysosomal Storage Diseases [Internet].

Ratko TA, Marbella A, Godfrey S, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jan. (Technical Briefs, No. 12.)

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Select item 48538167.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 18813828.

Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition.

Siegel GJ, Agranoff BW, Albers RW, et al., editors.

Philadelphia: Lippincott-Raven; 1999.

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Select item 30973509.

Safe and Effective Medicines for Children: Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act.

Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA); Board on Health Sciences Policy; Institute of Medicine; Field MJ, Boat TF, editors.

Washington (DC): National Academies Press (US); 2012 Feb 29.

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Select item 436691810.

Galsulfase (Naglazyme) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Nov.

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Select item 456572811.

Drugs and Lactation Database (LactMed®) [Internet].

Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Select item 239383612.

RefSeq Help [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2011-.

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Select item 265918213.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Supplemental Content

Images search in Bookshelf

Figure 4.3Sequence of the first two exons of human iduronate sulfatase gene

The figure shows the DNA sequence of the positions 15391–15571 of human X chromosome. The iduronate sulfatase mRNA and its coding sequence are shown as thick lines; the corresponding amino acid residues are shown underneath. “Variation” indicates the positions of mapped mutations causing type II mucopolysaccharidosis.

Principles and Methods of Sequence Analysis.

Koonin EV, Galperin MY. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. Boston: Kluwer Academic; 2003.
Figure 4

Degradation of heparan sulphate Enzymes participating in this degradation pathway are (1) Iduronate sulfatase (2) α-Idorunidase (3) Heparan sulfatase (4) Acetyl-CoA transferase (5) N-acetyl glucosaminidase (6) Glucuronate sulfatase (7) β-glucuronidase (8) N-acetyl glucosamine 6-sulfatase.

Lysosomal Storage Disorders.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 4.2Organization of the human iduronate 2-sulfatase gene

This gene is located in positions 152960–177995 of human X chromosome and encodes a 550-aa precursor protein that contains a 25-aa N-terminal signal sequence, followed by eight amino acids that are removed in the course of protein maturation. Mutations in this gene cause mucopolysaccharidosis type II, also known as Hunter's disease, which results in tissue deposits of chondroitin sulfate and heparin sulfate. The symptoms of Hunter's disease include dysostosis with dwarfism, coarse facial features, hepatosplenomegaly, cardiovascular disorders, deafness, and, in some cases, progressive mental retardation (see OMIM 309900). The top line indicates the X chromosome and shows the location of the iduronate sulfatase gene (thick line in the middle). Thin lines on the bottom indicate two alternative transcripts. Exons are shown with small rectangles. The square bracket above the iduronate sulfatase gene marks the region of the gene shown in Figure 4.3.

Principles and Methods of Sequence Analysis.

Koonin EV, Galperin MY. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. Boston: Kluwer Academic; 2003.