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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Select item 34012942.

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 26591823.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 14589844.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2024.

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Select item 48538165.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 54796886.

Screening for Lipid Disorders in Children and Adolescents: An Evidence Update for the U.S. Preventive Services Task Force [Internet].

Guirguis-Blake JM, Evans CV, Coppola EL, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2023 Jul. (Evidence Synthesis, No. 229.)

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Select item 29244387.

Elucigene FH20 and LIPOchip for the Diagnosis of Familial Hypercholesterolaemia: A Systematic Review and Economic Evaluation.

Sharma P, Boyers D, Boachie C, et al.

Southampton (UK): NIHR Journals Library; 2012 Mar. (Health Technology Assessment, No. 16.17.)

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Select item 42615748.

Lomitapide (Juxtapid) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Select item 48841289.

Familial hypercholesterolaemia: identification and management: Evidence reviews for case-finding, diagnosis and statin monotherapy.

London: National Institute for Health and Care Excellence (NICE); 2017 Nov. (NICE Guideline, No. 71.)

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Select item 563329810.

Evinacumab (Evkeeza): CADTH Reimbursement Review: Therapeutic area: Homozygous familial hypercholesterolemia [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2024 Apr.

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Select item 555402811.

Inclisiran (Leqvio): CADTH Reimbursement Review: Therapeutic area: Primary hypercholesterolemia [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2022 Apr.

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Select item 430903412.

Lipid Screening in Childhood and Adolescence for Detection of Familial Hypercholesterolemia: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].

Lozano P, Henrikson NB, Dunn J, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Aug. (Evidence Syntheses, No. 141.)

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Select item 536791013.

Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets [Internet].

von Eckardstein A, Binder CJ, editors.

Cham (CH): Springer; 2022.

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Select item 552734614.

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.

Qureshi N, Woods B, Neves de Faria R, et al.

Southampton (UK): National Institute for Health and Care Research; 2023 Oct. (Health Technology Assessment, No. 27.16.)

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Select item 547384815.

Bleeding risk in patients prescribed dual antiplatelet therapy and triple therapy after coronary interventions: the ADAPTT retrospective population-based cohort studies.

Harris J, Pouwels KB, Johnson T, et al.

Southampton (UK): National Institute for Health and Care Research; 2023 May. (Health Technology Assessment, No. 27.08.)

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Select item 451825416.

Variation in outcome of hospitalised patients with out-of-hospital cardiac arrest from acute coronary syndrome: a cohort study.

Couper K, Kimani PK, Gale CP, et al.

Southampton (UK): NIHR Journals Library; 2018 Mar. (Health Services and Delivery Research, No. 6.14.)

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Select item 317235617.

Diet and Health: Implications for Reducing Chronic Disease Risk.

National Research Council (US) Committee on Diet and Health.

Washington (DC): National Academies Press (US); 1989.

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Select item 262532818.

InformedHealth.org [Internet].

Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-.

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Select item 141528019.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 281229020.

Adjunctive Devices for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention [Internet].

Sobieraj DM, White CM, Kluger J, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Dec. (Comparative Effectiveness Reviews, No. 42.)

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Supplemental Content

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FIGURE 2.

Approach to the Pharmacologic Treatment of Patients with Heterozygous Familial Hypercholesterolemia

Familial Hypercholesterolemia: Genes and Beyond.

Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Figure 8Familial Hypercholesterolemia (FH): Statin Intervention Trials—FH Criteria Reported (Key Question 4)

Abbreviations: CAD = coronary artery disease; CVD = cardiovascular disease; FH = familial hypercholesterolemia; LDL-C = low-density lipoprotein cholesterol; mg/dL = milligrams per deciliter; TC = total cholesterol

Results.

Guirguis-Blake JM, Evans CV, Coppola EL, et al. Screening for Lipid Disorders in Children and Adolescents: An Evidence Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2023 Jul.
Figure 12Familial Hypercholesterolemia (FH), Multifactorial Dyslipidemia (MFD), and MFD/FH: All Treatment Intervention Trials—Study Duration, by Condition (Key Question 4)

Abbreviations: DHA = Docosahexaenoic acid; EPA = Eicosapentaenoic acid; FH = familial hypercholesterolemia; MFD = multifactorial dyslipidemia; PCSK9 = Proprotein convertase subtilisin/kexin type 9

Results.

Guirguis-Blake JM, Evans CV, Coppola EL, et al. Screening for Lipid Disorders in Children and Adolescents: An Evidence Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2023 Jul.
Figure 1.

LDL cholesterol burden in individuals with or without familial hypercholesterolemia as a function of the age of initiation of statin therapy
Data derived from Starr et al [2008] and Huijgen et al [2012]. Figure from Nordestgaard et al [2013]; used by permission of Oxford University Press.

Familial Hypercholesterolemia.

Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.