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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2026 Jan-.

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Select item 34012942.

Endotext [Internet].

Feingold KR, Adler RA, Ahmed SF, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 33342723.

Educational interventions for preventing vascular catheter bloodstream infections in critical care: evidence map, systematic review and economic evaluation.

Frampton GK, Harris P, Cooper K, et al.

Southampton (UK): NIHR Journals Library; 2014 Feb. (Health Technology Assessment, No. 18.15.)

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Select item 52876544.

Management of thyrotoxicosis: - drugs vs surgery vs radioactive iodine - safety of treatment with radioactive iodine: Thyroid disease: assessment and management: Evidence review I.

National Guideline Centre (UK).

London: National Institute for Health and Care Excellence (NICE); 2019 Nov. (NICE Guideline, No. 145.)

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Select item 44650645.

Autoimmunity: From Bench to Bedside [Internet].

Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors.

Bogota (Colombia): El Rosario University Press; 2013 Jul 18.

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Select item 48538166.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 26591827.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 53250688.

Enhancing NIH Research on Autoimmune Disease.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee for the Assessment of NIH Research on Autoimmune Diseases.

Washington (DC): National Academies Press (US); 2022 Jun 2.

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Select item 26253289.

InformedHealth.org [Internet].

Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-.

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Select item 141528010.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 145898411.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 144534212.

Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.

Walker HK, Hall WD, Hurst JW, editors.

Boston: Butterworths; 1990.

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Select item 145639013.

Endocrinology: An Integrated Approach.

Nussey S, Whitehead S.

Oxford: BIOS Scientific Publishers; 2001.

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Select item 429903414.

A cost-effectiveness modelling study of strategies to reduce risk of infection following primary hip replacement based on a systematic review.

Graves N, Wloch C, Wilson J, et al.

Southampton (UK): NIHR Journals Library; 2016 Jul. (Health Technology Assessment, No. 20.54.)

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Select item 318743215.

Medicare Coverage of Routine Screening for Thyroid Dysfunction.

Institute of Medicine (US) Committee on Medicare Coverage of Routine Thyroid Screening; Stone MB, Wallace RB, editors.

Washington (DC): National Academies Press (US); 2003.

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Select item 279182016.

Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism [Internet].

Rugge B, Balshem H, Sehgal R, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Oct. (Comparative Effectiveness Reviews, No. 24.)

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Select item 404737817.

Screening for and Treatment of Thyroid Dysfunction: An Evidence Review for the U.S. Preventive Services Task Force [Internet].

Rugge JB, Bougatsos C, Chou R.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Oct. (Evidence Syntheses, No. 118.)

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Select item 337849218.

Reducing Care Utilisation through Self-management Interventions (RECURSIVE): a systematic review and meta-analysis.

Panagioti M, Richardson G, Murray E, et al.

Southampton (UK): NIHR Journals Library; 2014 Dec. (Health Services and Delivery Research, No. 2.54.)

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Select item 509198219.

NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice: Technical Report 597 [Internet].

National Toxicology Program.

Research Triangle Park (NC): National Toxicology Program; 2020 May.

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Select item 528993420.

Management of thyrotoxicosis: anti thyroid drugs: Thyroid disease: assessment and management: Evidence review J.

National Guideline Centre (UK).

London: National Institute for Health and Care Excellence (NICE); 2019 Nov. (NICE Guideline, No. 145.)

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Supplemental Content

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Figure 13.9Feedback regulation of thyroid hormone production is disrupted in Graves' disease

Graves' disease is caused by autoantibodies specific for the receptor for thyroidstimulating hormone (TSH). Normally, thyroid hormones are produced in response to TSH and limit their own production by inhibiting the production of TSH by the pituitary (left panels). In Graves' disease, the autoantibodies are agonists for the TSH receptor and therefore stimulate production of thyroid hormones (right panels). The thyroid hormones inhibit TSH production in the normal way but do not affect production of the autoantibody; the excessive thyroid hormone production induced in this way causes hyperthyroidism.

Autoimmune responses are directed against self antigens.

Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001.
Figure 5.

Histology of a thyroid gland of a patient with Graves’ disease. Columnar epithelium, vacuolization of colloid, and significant lymphocytic infiltrate are present in the setting of diffuse parenchymal hypertrophy.

Graves’ Disease and the Manifestations of Thyrotoxicosis.

Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Figure 3.

Risk factors for Graves’ disease. MHC: Major histocompatibility complex; HLA: Human leukocyte antigen; CTLA: Cytotoxic T-lymphocyte-associated protein; RNA: Ribonucleic acid. (Created with Biorender.com).

Graves’ Disease and the Manifestations of Thyrotoxicosis.

Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
Figure 2.

Stimulation of thyroid hormone secretion by LATS-P. The subject's thyroid iodine was labeled by administration of I¹³¹, and serial observations were made on the appearance of I¹³¹-labeled hormone in blood (Y axis) over one month (X axis). An infusion of 280 ml control plasma had no effect, but 280 ml plasma from a patient with Graves' disease caused a marked stimulation of secretion of hormone from the thyroid. (Adapted from: D.D. Adams et al., J. Clin. Endocrinol. Metab., 39:826, 1974).

Graves’ Disease and the Manifestations of Thyrotoxicosis.

Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.