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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2026 Jan-.

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Select item 48538162.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 26591823.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 13988524.

Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives: Supplement to Volume 77(6) of American Journal of Tropical Medicine and Hygiene.

Breman JG, Alilio MS, White NJ, editors.

Northbrook (IL): American Society of Tropical Medicine and Hygiene; 2007 Dec.

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Select item 49600025.

Treatment of Depression in Children and Adolescents: A Systematic Review [Internet].

Viswanathan M, Kennedy SM, McKeeman J, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Apr. (Comparative Effectiveness Review, No. 224.)

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Select item 14589846.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 56895647.

Avatrombopag (Doptelet): Therapeutic area: Chronic immune thrombocytopenia: CADTH Reimbursement Review [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2024 Sep.

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Select item 40929868.

Psychological Testing in the Service of Disability Determination.

Committee on Psychological Testing, Including Validity Testing, for Social Security Administration Disability Determinations; Board on the Health of Select Populations; Institute of Medicine.

Washington (DC): National Academies Press (US); 2015 Jun 29.

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Select item 46559069.

Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 1987. (IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS, No. Supplement 7.)

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Select item 548810610.

Alternative Therapies to Immunoglobulin for Autoimmune Blistering Diseases: CADTH Health Technology Review [Internet].

Tran K, Walter M; Authors.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2023 May.

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Select item 562156411.

Guidelines for Pediatric Immune Thrombocytopenia: Rapid Review [Internet].

Hui D, Barbara A, McGill SC; Authors.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2022 Jun.

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Select item 408650012.

Genetic Testing for Developmental Disabilities, Intellectual Disability, and Autism Spectrum Disorder [Internet].

Sun F, Oristaglio J, Levy SE, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Jun. (Technical Briefs, No. 23.)

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Select item 550122813.

Cost-Effectiveness of Treatment for Pediatric Immune Thrombocytopenia: CADTH Health Technology Review [Internet].

Tran K, Lê ML; Authors.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2022 May.

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Select item 456572814.

Drugs and Lactation Database (LactMed®) [Internet].

Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Select item 282062215.

Medical Genetics Summaries [Internet].

Pratt VM, Scott SA, Pirmohamed M, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

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Select item 166869016.

Holland-Frei Cancer Medicine. 6th edition.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors.

Hamilton (ON): BC Decker; 2003.

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Select item 446506417.

Autoimmunity: From Bench to Bedside [Internet].

Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors.

Bogota (Colombia): El Rosario University Press; 2013 Jul 18.

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Select item 543074618.

Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Reports [Internet].

Rockville (MD): Agency for Healthcare Research and Quality (US); 2020 Jul-.

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Select item 549748219.

Treatment of Adult Patients With Chronic Immune Thrombocytopenia After Failure of First-Line Therapies: CADTH Health Technology Review [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2023 Jul.

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Select item 313419220.

Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance.

Institute of Medicine (US) Committee on the Economics of Antimalarial Drugs; Arrow KJ, Panosian C, Gelband H, editors.

Washington (DC): National Academies Press (US); 2004.

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Molecular weight: 248.7
Pyrimethamine is a diaminopyrimidine used in combination with a sulfonamide, usually sulfadoxine or dapsone. It exerts its antimalarial activity by inhibiting plasmodial dihydrofolate reductase thus indirectly blocking the synthesis of nucleic acids in the malaria parasite. It is a slow-acting blood schizontocide and is also possibly active against pre-erythrocytic forms of the malaria parasite and inhibits sporozoite development in the mosquito vector. It is effective against all four human malarials, although resistance has emerged rapidly.

PHARMACOLOGY OF ANTIMALARIAL MEDICINES.

Guidelines for the Treatment of Malaria. 2nd edition. Geneva: World Health Organization; 2010.
Figure 3.

The 2014 International Consensus Guidelines on Screening, Diagnosis, and Management of PTDM
1Seldom performed in clinical practice (time-consuming/cost). 2 A1C cannot be accurately interpreted within the first 3 months after transplantation because anemia and impaired graft function can directly interfere with the A1C assay. Recent blood transfusion and dapsone may alter A1C level. 3A1C alone < 365 days may underestimate PTDM and require confirmatory testing. 4Within the past several years newer injectable antidiabetic agents have increasingly been used (however, it should also be noted that evidenced-based recommendations are lacking). PTDM, post-transplantation diabetes mellitus; OGTT, oral glucose tolerance test; A1C, hemoglobin A1C

Diabetes Mellitus After Solid Organ Transplantation.

Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.