"Chromosomal Instability" - Books

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Select item 14152801.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 14589842.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 44036683.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2026 Jan-.

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Select item 16686904.

Holland-Frei Cancer Medicine. 6th edition.

Kufe DW, Pollock RE, Weichselbaum RR, et al., editors.

Hamilton (ON): BC Decker; 2003.

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Select item 29807925.

Chromosomal Variation in Man: A Catalog of Chromosomal Variants and Anomalies: Online NLM Version [Internet].

Borgaonkar DS.

Bethesda (MD): National Center for Biotechnology Information (US); 1975-.

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Select item 28215246.

PDQ Cancer Information Summaries [Internet].

Bethesda (MD): National Cancer Institute (US); 2002-.

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Select item 34012947.

Endotext [Internet].

Feingold KR, Adler RA, Ahmed SF, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 51971328.

Tumour Site Concordance and Mechanisms of Carcinogenesis.

Baan RA, Stewart BW, Straif K, editors.

Lyon (FR): International Agency for Research on Cancer; 2019. (IARC Scientific Publications, No. 165.)

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Select item 18957889.

Molecular Biology of the Cell. 4th edition.

Alberts B, Johnson A, Lewis J, et al.

New York: Garland Science; 2002.

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Select item 568310610.

World Cancer Report: Cancer research for cancer prevention.

Wild CP, Weiderpass E, Stewart BW, editors.

Lyon (FR): International Agency for Research on Cancer; 2020.

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Select item 136515011.

Dynamics of Cancer: Incidence, Inheritance, and Evolution.

Frank SA.

Princeton (NJ): Princeton University Press; 2007.

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Select item 408515612.

Biological Agents.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100B.)

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Select item 186024213.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 572544614.

IRIS Toxicological Review of Hexavalent Chromium [Cr(VI)] CASRN 18540-29-9.

Gibbons CF, Sasso AF, Angrish MM, et al.

Washington (DC): U.S. Environmental Protection Agency; 2024 Aug.

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Select item 244094615.

How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General.

Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US).

Atlanta (GA): Centers for Disease Control and Prevention (US); 2010.

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Select item 544913416.

15th Report on Carcinogens [Internet].

National Toxicology Program.

Research Triangle Park (NC): National Toxicology Program; 2021 Dec 21.

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Select item 219516217.

StemBook [Internet].

Cambridge (MA): Harvard Stem Cell Institute; 2008-.

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Select item 408618818.

Arsenic, Metals, Fibres and Dusts.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100C.)

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Select item 575295019.

IRIS Toxicological Review of Formaldehyde (Inhalation) CASRN 50-00-0.

Kraft A, Bateson TF, Glenn B, et al.

Washington (DC): U.S. Environmental Protection Agency; 2024 Aug.

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Select item 408460620.

Chemical Agents and Related Occupations.

IARC Working Group on the Evaluation of Carcinogenic Risks to Humans.

Lyon (FR): International Agency for Research on Cancer; 2012. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 100F.)

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Supplemental Content

Images search in Bookshelf

Figure 2

Genetic abnormalities, histological changes, and screening methods in the occurrence and development process of CRC. CIMP, CpG island methylator phenotype; CIN, chromosomal instability; FIT, fecal immunochemical test; FOBT, fecal occult blood test; MSI, microsatellite instability.

Colorectal Cancer: An Overview.

Morgado-Diaz JA, editor. Gastrointestinal Cancers [Internet]. Brisbane (AU): Exon Publications; 2022 Sep 30.
Figure 3.

The chromosomal instability pathway of tumorigenesis. As tumors progress down the chromosomal instability (CIN) pathway from early stage adenomas to carcinomas, they acquire somatic mutations that result in aberrant Wnt signaling. Accumulation of mutations leads to invasion, malignancy, regional lymph node metastasis, and distant metastasis, primarily in the liver and lungs. Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are thought to contribute to local invasion and metastasis, respectively. Figure adapted from John Hopkins Medicine, 2010.177

MicroRNAs and the Progression of Colorectal Cancer.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 3.2

Morphology of colorectal cancer progression. This classical pathway is characterized by traditional adenoma morphology, slow progression, high adenoma:carcinoma ratio, frequent chromosomal instability and aneuploidy, and rare microsatellite instability. Particular genetic changes often associate with morphological stage, suggesting that the genetic changes play an important role in driving progression. Approximately 50–85 percent of colorectal cancers follow this pathway. Redrawn from Figure 3 of Fearon and Vogelstein (1990).

Multistage Progression.

Frank SA. Dynamics of Cancer: Incidence, Inheritance, and Evolution. Princeton (NJ): Princeton University Press; 2007.
Figure 3DNA methylation patterns.

(a) Basal state of CpG islands is been unmethylated to allow the transcription, but when they are methylated at promoter regions of genes the transcription will be inhibited. (b) At the same time, CpG island shores located up to ~2 kb of CpG islands have a similar methylation pattern to the CpG islands in which methylation is closely associated with transcriptional inactivation. (c) Gene bodies are methylated to prevent spurious transcription initiations. (d) Repetitive sequences which are hypermethylated to protect chromosomal integrity by preventing reactivation of endoparasitic sequences that causes chromosomal instability.

Epigenetics and autoimmune diseases.

Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18.