"Brefeldin A" - Books

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Results: 14 books (63 items)

Select item 14152801.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 52797182.

Evidence reviews for sepsis: Intrapartum care for women with existing medical conditions or obstetric complications and their babies: Evidence review M.

National Guideline Alliance (UK).

London: National Institute for Health and Care Excellence (NICE); 2019 Mar. (NICE Guideline, No. 121.)

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Select item 15020683.

Annual Reviews Collection [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2002 Nov.

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Select item 16868404.

Retroviruses.

Coffin JM, Hughes SH, Varmus HE, editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

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Select item 23580525.

Probe Reports from the NIH Molecular Libraries Program [Internet].

Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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Select item 23639746.

Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.

Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.

Cambridge: Cambridge University Press; 2007.

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Select item 54829307.

Glycoscience Protocols (GlycoPODv2) [Internet].

Nishihara S, Angata K, Aoki-Kinoshita KF, et al., editors.

Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021-.

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Select item 23871568.

Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

Noebels JL, Avoli M, Rogawski MA, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012.

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Select item 53216729.

Essentials of Glycobiology [Internet]. 4th edition.

Varki A, Cummings RD, Esko JD, et al., editors.

Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022.

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Select item 554555810.

Toxicological Profile for Ammonia.

Atlanta (GA): Agency for Toxic Substances and Disease Registry (US); 2004 Sep.

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Select item 557379411.

$Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT.$

Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCT.

Lindsay JO, Hind D, Swaby L, et al.

Southampton (UK): National Institute for Health and Care Research; 2024 Jan. (Efficacy and Mechanism Evaluation, No. 11.03.)

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Select item 186024212.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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Select item 290697613.

TRP Channels.

Zhu MX, editor.

Boca Raton (FL): CRC Press/Taylor & Francis; 2011.

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Select item 563261214.

Electromechanobiology of Cartilage and Osteoarthritis: A Tribute to Alan Grodzinsky on his 75th Birthday [Internet].

Connizzo BK, Han L, Sah RL, editors.

Cham (CH): Springer; 2023.

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Figure 13-8Electron micrographs showing the effect of brefeldin A treatment on the Golgi apparatus

A histochemical stain shows the location of a Golgi enzyme (a mannosidase) before (A) and two hours after (B) brefeldin A treatment of cultured fibroblasts. Note that after the treatment the enzyme relocates from the cis and medialGolgi cisternae to the ER and to the nuclear envelope, which is continuous with the ER. (Courtesy of Jennifer Lippincott-Schwartz and Lydia Yuan.)

Transport from the ER Through the Golgi Apparatus .

Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.
Figure 13-9The postulated return pathway from the Golgi apparatus to the ER

Whereas the forward pathway requires transport vesicles and occurs independently of microtubules, the return pathway is thought to involve membrane tubes that are pulled from the Golgi apparatus to the ER along microtubules (which are disrupted by drugs such as nocodazole). As we discuss later, brefeldin A prevents the assembly of the coats that are required for budding of the transport vesicles, and this may block the forward vesicular transport steps while leaving the backward membrane-tube-dependent transport process intact.

Transport from the ER Through the Golgi Apparatus .

Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.
Figure 13-55A current model of coatomer-coated vesicle formation

(A) Inactive, soluble ARF-GDP binds to a guanine-nucleotide-releasing protein in the donor membrane, causing the ARF to release its GDP and bind GTP. A GTP-triggered conformational change in ARF exposes its fatty acid chain, which inserts into the donor membrane. (B) Membrane-bound, active ARF-GTP recruits coatomer subunits to the membrane. This causes the membrane to form a bud. A sub-sequent membrane-fusion event pinches off and releases the coated vesicle. The drug brefeldin A blocks coatomer-coat assembly by inhibiting the exchange reaction of GDP to GTP. This blocks coatomer-coated vesicular traffic from the ER through the Golgi apparatus, causing the Golgi apparatus to empty into the ER, as explained on page 604.

The Molecular Mechanisms of Vesicular Transport and the Maintenance of Compartmental Diversity .

Alberts B, Bray D, Lewis J, et al. Molecular Biology of the Cell. 3rd edition. New York: Garland Science; 1994.