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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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Select item 26591822.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 33558663.

Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews.

Sutcliffe P, Connock M, Gurung T, et al.

Southampton (UK): NIHR Journals Library; 2013 Sep. (Health Technology Assessment, No. 17.43.)

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Select item 48538164.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.

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Select item 40681645.

The prognostic utility of tests of platelet function for the detection of ‘aspirin resistance’ in patients with established cardiovascular or cerebrovascular disease: a systematic review and economic evaluation.

Dretzke J, Riley RD, Lordkipanidzé M, et al.

Southampton (UK): NIHR Journals Library; 2015 May. (Health Technology Assessment, No. 19.37.)

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Select item 26253286.

InformedHealth.org [Internet].

Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-.

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Select item 47921627.

Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCT.

Hull MA, Sprange K, Hepburn T, et al.

Southampton (UK): NIHR Journals Library; 2019 Jun. (Efficacy and Mechanism Evaluation, No. 6.4.)

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Select item 53335548.

Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: An Updated Decision Analysis for the U.S. Preventive Services Task Force [Internet].

Dehmer SP, O’Keefe LR, Grossman ES, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 Apr. (Technical Report, No. 211s.)

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Select item 14589849.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2025.

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Select item 296984010.

Clopidogrel and Modified-Release Dipyridamole for the Prevention of Occlusive Vascular Events (Review of Technology Appraisal No. 90): A Systematic Review and Economic Analysis.

Greenhalgh J, Bagust A, Boland A, et al.

Southampton (UK): NIHR Journals Library; 2011 Sep. (Health Technology Assessment, No. 15.31.)

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Select item 412795611.

Aspirin Use in Adults: Cancer, All-Cause Mortality, and Harms: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].

Whitlock EP, Williams SB, Burda BU, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Sep. (Evidence Syntheses, No. 132.)

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Select item 438788012.

Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis.

Sterne JAC, Bodalia PN, Bryden PA, et al.

Southampton (UK): NIHR Journals Library; 2017 Mar. (Health Technology Assessment, No. 21.9.)

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Select item 474505813.

Clinical Review Report: Ticagrelor (Brilinta) [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Aug.

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Select item 466763414.

Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update [Internet].

Sanders GD, Lowenstern A, Borre E, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Oct. (Comparative Effectiveness Reviews, No. 214.)

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Select item 340129415.

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 547384816.

Bleeding risk in patients prescribed dual antiplatelet therapy and triple therapy after coronary interventions: the ADAPTT retrospective population-based cohort studies.

Harris J, Pouwels KB, Johnson T, et al.

Southampton (UK): National Institute for Health and Care Research; 2023 May. (Health Technology Assessment, No. 27.08.)

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Select item 497458217.

Evidence reviews for pharmacological treatment in people with suspected or confirmed deep vein thrombosis and/or pulmonary embolism: Venous thromboembolic diseases: diagnosis, management and thrombophilia testing: Evidence review D.

London: National Institute for Health and Care Excellence (NICE); 2020 Mar. (NICE Guideline, No. 158.)

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Select item 477854018.

Clinical Review Report: Rivaroxaban (Xarelto): Bayer Inc. Indication: In combination with 75 mg to 100 mg acetylsalicylic acid, for the prevention of stroke, myocardial infarction, and cardiovascular death, and for the prevention of acute limb ischemia and mortality in patients with coronary artery disease with or without peripheral artery disease [Internet].

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Jan.

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Select item 463265619.

AVURT: aspirin versus placebo for the treatment of venous leg ulcers – a Phase II pilot randomised controlled trial.

Tilbrook H, Clark L, Cook L, et al.

Southampton (UK): NIHR Journals Library; 2018 Oct. (Health Technology Assessment, No. 22.55.)

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Select item 532400020.

Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force [Internet].

Guirguis-Blake JM, Evans CV, Perdue LA, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 Apr. (Evidence Synthesis, No. 211.)

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Supplemental Content

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Figure 5Duration of Randomized Aspirin Use and Timepoints for CRC Incidence and Mortality

Abbreviations: AAA = Aspirin for Asymptomatic Atherosclerosis; ARRIVE = Aspirin to Reduce Risk of Initial Vascular Events; ASA = aspirin; ASCEND = A Study of Cardiovascular Events in Diabetes; ASPREE = Aspirin in Reducing Events in the Elderly; BMD = British Male Doctors; CRC = colorectal cancer; HOT = Hypertension Optimal Treatment Study; JPAD = Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes; JPPP = Japanese Primary Prevention Project; PHS = Physician’s Health Study; POPADAD = The Prevention of Progression of Arterial Disease and Diabetes trial; PPP = Primary Prevention Project; SALT = Swedish Aspirin Low-dose Trial; TPT Thrombosis Prevention Trial; UK-TIA = United Kingdom Transient Ischaemic Attack; WHS = Women’s Health Study

Results.

Guirguis-Blake JM, Evans CV, Perdue LA, et al. Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: An Evidence Update for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2022 Apr.
Figure H.2Cost-effectiveness plane comparing aspirin use in pregnant women at risk of developing pre-eclampsia with no aspirin

Cost effectiveness of aspirin compared with no aspirin in preventing pre-eclampsia in women at risk of developing pre-eclampsia.

National Collaborating Centre for Women's and Children's Health (UK). Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy. London: RCOG Press; 2010 Aug.
Appendix F Figure 9Aspirin vs. Placebo/Control, Intracranial Bleeding

Q =0.29 df=1, p= 0.59, I-sq= 0.00
For AFASAK: zero for aspirin and zero for placebo. For SPAF I: aspirin, one fatal intracerebral hemorrhage and one fatal subdural hematoma; placebo, two subdural hematomas with full recovery.

Additional Meta-Analysis Results.

Jonas DE, Kahwati LC, Yun JDY, et al. Screening for Atrial Fibrillation With Electrocardiography: An Evidence Review for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Aug.
Figure H.4Sensitivity analysis showing QALY loss for women not taking aspirin compared with those taking aspirin in women at risk of developing pre-eclampsia, varying short-term utility loss from pre-eclampsia over a range suggested by the GDG

Cost effectiveness of aspirin compared with no aspirin in preventing pre-eclampsia in women at risk of developing pre-eclampsia.

National Collaborating Centre for Women's and Children's Health (UK). Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy. London: RCOG Press; 2010 Aug.