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Select item 44036681.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Select item 26591822.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Select item 44289803.

Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia [Internet].

Kane RL, Butler M, Fink HA, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Mar. (Comparative Effectiveness Reviews, No. 188.)

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Select item 34012944.

Endotext [Internet].

Feingold KR, Anawalt B, Blackman MR, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 29057705.

Aging in Asia: Findings From New and Emerging Data Initiatives.

National Research Council (US) Panel on Policy Research and Data Needs to Meet the Challenge of Aging in Asia; Smith JP, Majmundar M, editors.

Washington (DC): National Academies Press (US); 2012.

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Select item 14152806.

Madame Curie Bioscience Database [Internet].

Austin (TX): Landes Bioscience; 2000-2013.

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Select item 32989707.

Sociality, Hierarchy, Health: Comparative Biodemography: A Collection of Papers.

Committee on Population; Division of Behavioral and Social Sciences and Education; National Research Council; Weinstein M, Lane MA, editors.

Washington (DC): National Academies Press (US); 2014 Sep 22.

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Select item 54156148.

Understanding the Aging Workforce: Defining a Research Agenda.

National Academies of Sciences, Engineering, and Medicine; Division of Behavioral and Social Sciences and Education; Committee on National Statistics;Committee on Population; Committee on Understanding the Aging Workforce and Employment at Older Ages; Becker T, Fiske ST, editors.

Washington (DC): National Academies Press (US); 2022 May 5.

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Select item 36107249.

Cognitive Aging: Progress in Understanding and Opportunities for Action.

Committee on the Public Health Dimensions of Cognitive Aging; Board on Health Sciences Policy; Institute of Medicine; Blazer DG, Yaffe K, Liverman CT, editors.

Washington (DC): National Academies Press (US); 2015 Jul 21.

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Select item 313791410.

Testosterone and Aging: Clinical Research Directions.

Institute of Medicine (US) Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy; Liverman CT, Blazer DG, editors.

Washington (DC): National Academies Press (US); 2004.

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Select item 315028211.

The Aging Population in the Twenty-First Century: Statistics for Health Policy.

National Research Council (US) Panel on Statistics for an Aging Population; Gilford DM, editor.

Washington (DC): National Academies Press (US); 1988.

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Select item 304031012.

Aging and the Macroeconomy: Long-Term Implications of an Older Population.

Institute of Medicine (US) Committee on the Long-Run Macroeconomic Effects of the Aging U.S. Population.

Washington (DC): National Academies Press (US); 2012 Dec 10.

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Select item 309882613.

Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis.

Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population; Board on Health Care Services; Institute of Medicine; Levit L, Balogh E, Nass S, et al., editors.

Washington (DC): National Academies Press (US); 2013 Dec 27.

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Select item 297454014.

Between Zeus and the Salmon: The Biodemography of Longevity.

National Research Council (US) Committee on Population; Wachter KW, Finch CE, editors.

Washington (DC): National Academies Press (US); 1997.

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Select item 145259415.

Brain Aging: Models, Methods, and Mechanisms.

Riddle DR, editor.

Boca Raton (FL): CRC Press/Taylor & Francis; 2007.

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Select item 316494416.

The Social and Built Environment in an Older Society.

Institute of Medicine (US) and National Research Council (US) Committee on an Aging Society.

Washington (DC): National Academies Press (US); 1988.

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Select item 291983817.

Technology for Adaptive Aging.

National Research Council (US) Steering Committee for the Workshop on Technology for Adaptive Aging; Pew RW, Van Hemel SB, editors.

Washington (DC): National Academies Press (US); 2004.

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Select item 145898418.

GeneReviews® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2024.

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Select item 456372619.

Future Directions for the Demography of Aging: Proceedings of a Workshop.

National Academies of Sciences, Engineering, and Medicine; Division of Behavioral and Social Sciences and Education; Committee on Population; Majmundar MK, Hayward MD, editors.

Washington (DC): National Academies Press (US); 2018 Jun 26.

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Select item 186024220.

WormBook: The Online Review of C. elegans Biology [Internet].

Pasadena (CA): WormBook; 2005-2018.

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FIGURE 1Guiding Model for Healthy Aging

SOURCE: Modified from: Rowe JW, Kahn RL. Successful Aging. New York: Pantheon, 1998; and Marshal VW, Altpeter M. Health & Social Work 2005; 30(2):135-144.

Healthy Aging in Action: Advancing the National Prevention Strategy.

National Prevention Council. Healthy Aging in Action: Advancing the National Prevention Strategy [Internet]. Washington (DC): US Department of Health and Human Services; 2016 Nov.
Figure 6

Model to explain sgs1 and WS phenotypes. Defects in Sgs1 or WRN lead to genome instability that is manifested as premature aging and non-aging phenotypes. In S. cerevisiae, a major cause of aging in normal cells stems from the instability of the repeated ribosomal DNA (rDNA) locus. Aging in yeast is accompanied by a slowing of the cell cycle, fragmentation of the nucleolus, the relocalization of the Sir complex from telomeres and mating-type loci to the nucleolus, resulting in a sterile, pseudo-diploid state. Life span in sgs1 mutants is a composite of normal aging and stochastic death due to defects in DNA replication (see Fig. 4). Similarly, WS is the consequence of aging- and non-aging-related symptoms stemming from different aspects of genome instability. Non-aging related processes in both species can give rise to phenotypes that resemble normal aging.

Yeast RecQ Helicases: Clues to DNA Repair, Genome Stability and Aging.

Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
FIGURE 2–5

Percentage increase in older population, by decade, 1900–2050. Source: U.S. Senate Special Committee on Aging (1986).

The Aging Population and the Psychosocial Implications of Aging.

National Research Council (US) Committee on Chemical Toxicology and Aging. Aging In Today's Environment. Washington (DC): National Academies Press (US); 1987.
FIGURE 2–6

Percentage of population with severe activity limitation, 1982. Source: U.S. Senate Special Committee on Aging (1986).

The Aging Population and the Psychosocial Implications of Aging.

National Research Council (US) Committee on Chemical Toxicology and Aging. Aging In Today's Environment. Washington (DC): National Academies Press (US); 1987.