"Adrenarche" - Books

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Select item 34012941.

Endotext [Internet].

Feingold KR, Adler RA, Ahmed SF, et al., editors.

South Dartmouth (MA): MDText.com, Inc.; 2000-.

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Select item 44036682.

StatPearls [Internet].

Treasure Island (FL): StatPearls Publishing; 2025 Jan-.

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Select item 14589843.

GeneReviews® [Internet].

Adam MP, Bick S, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2026.

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Select item 14563904.

Endocrinology: An Integrated Approach.

Nussey S, Whitehead S.

Oxford: BIOS Scientific Publishers; 2001.

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Select item 29191225.

Offspring: Human Fertility Behavior in Biodemographic Perspective.

National Research Council (US) Panel for the Workshop on the Biodemography of Fertility and Family Behavior; Wachter KW, Bulatao RA, editors.

Washington (DC): National Academies Press (US); 2003.

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Select item 48006266.

Handbook of Life Course Health Development [Internet].

Halfon N, Forrest CB, Lerner RM, et al., editors.

Cham (CH): Springer; 2018.

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Select item 31697307.

Biologic Markers in Reproductive Toxicology.

National Research Council (US) Subcommittee on Reproductive and Neurodevelopmental Toxicology.

Washington (DC): National Academies Press (US); 1989.

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Select item 48228268.

The Promise of Adolescence: Realizing Opportunity for All Youth.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Division of Behavioral and Social Sciences and Education; Board on Children, Youth, and Families; Committee on the Neurobiological and Socio-behavioral Science of Adolescent Development and Its Applications; Backes EP, Bonnie RJ, editors.

Washington (DC): National Academies Press (US); 2019 May 16.

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Select item 57026329.

Diagnostic tests and diagnostic thresholds for referral: Adrenal insufficiency: identification and management: Evidence review D.

London: National Institute for Health and Care Excellence (NICE); 2024 Aug. (NICE Guideline, No. 243.)

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Select item 321912410.

Adolescent Development and the Biology of Puberty: Summary of a Workshop on New Research.

National Research Council (US) and Institute of Medicine (US) Forum on Adolescence; Kipke MD, editor.

Washington (DC): National Academies Press (US); 1999.

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Select item 460751611.

Child and Adolescent Health and Development. 3rd edition.

Bundy DAP, Silva Nd, Horton S, et al., editors.

Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 20.

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Select item 516431212.

NTP Monograph on the Systematic Review of Occupational Exposure to Cancer Chemotherapy Agents and Adverse Health Outcomes: NTP Monograph 05 [Internet].

National Toxicology Program.

Research Triangle Park (NC): National Toxicology Program; 2019 Mar.

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Select item 569722013.

When to refer for specialist investigation when withdrawing corticosteroids: Adrenal insufficiency: identification and management: Evidence review C.

London: National Institute for Health and Care Excellence (NICE); 2024 Aug. (NICE Guideline, No. 243.)

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Select item 319935214.

Exploring the Biological Contributions to Human Health: Does Sex Matter?

Institute of Medicine (US) Committee on Understanding the Biology of Sex and Gender Differences; Wizemann TM, Pardue ML, editors.

Washington (DC): National Academies Press (US); 2001.

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Select item 430371615.

The Interplay Between Environmental Chemical Exposures and Obesity: Proceedings of a Workshop.

Roundtable on Environmental Health Sciences, Research, and Medicine; Board on Population Health and Public Health Practice; Health and Medicine Division; National Academies of Sciences, Engineering, and Medicine.

Washington (DC): National Academies Press (US); 2016 Jul 28.

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Select item 144534216.

Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.

Walker HK, Hall WD, Hurst JW, editors.

Boston: Butterworths; 1990.

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Select item 565004817.

Low Birth Weight Babies and Disability.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Care Services; Committee on the Identification and Prognosis of Low Birth Weight Babies in Disability Determinations; Applegate A, Spicer CM, Frontera W, editors.

Washington (DC): National Academies Press (US); 2024 Feb 21.

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Select item 570336018.

A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures.

Carlson LM, Christensen K, Lehmann GM, et al.

Washington (DC): U.S. Environmental Protection Agency; 2023 Mar.

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Select item 570818619.

A New Vision for Women’s Health Research: Transformative Change at the National Institutes of Health.

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Assessment of NIH Research on Women’s Health; Geller A, Salganicoff A, Burke SP, editors.

Washington (DC): National Academies Press (US); 2025 Feb 14.

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Select item 479906420.

Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book [Internet].

Hodler J, Kubik-Huch RA, von Schulthess GK, editors.

Cham (CH): Springer; 2018.

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FIGURE 9-2Causal relationship of adrenarche and pubertal maturation

NOTE: The old model suggests that adrenal androgens produced by adrenarche are necessary for desensitizing the hypothalamus to the feedback effects of gonadal androgens thus allowing testicular production of testosterone to begin to rise. The new model incorporates both genetic and environmental factors in the onset of adrenarche and gonadarche. In addition to variation in the timing of hypothalamic and pituitary maturation, the onset of adrenal production of DHEA/S and gonadal production of testosterone are also related to energy availability, most likely in the form of fat storage. Adrenal production of DHEA/S may also alter hypothalamic-pituitary control of gonadotropins. The pubertal growth spurt is a product of both the onset of testicular production of testosterone and energy available for bone and muscle growth.

Pubertal Maturation, Adrenarche, and the Onset of Reproduction in Human Males.

National Research Council (US) Panel for the Workshop on the Biodemography of Fertility and Family Behavior; Wachter KW, Bulatao RA, editors. Offspring: Human Fertility Behavior in Biodemographic Perspective. Washington (DC): National Academies Press (US); 2003.
FIGURE 9-1Temporal relationship of adrenarche and puberty in human males

NOTE: This graph indicates the relative role of changes in DHEA/S and testosterone at different stages of the development of males from age 8 to 25. Both the young adult and juvenile stages are marked by changes in DHEA/S without changes in testosterone, whereas during adolescent both hormones are increasing.

Pubertal Maturation, Adrenarche, and the Onset of Reproduction in Human Males.

National Research Council (US) Panel for the Workshop on the Biodemography of Fertility and Family Behavior; Wachter KW, Bulatao RA, editors. Offspring: Human Fertility Behavior in Biodemographic Perspective. Washington (DC): National Academies Press (US); 2003.
Fig. 3

An integrated evolutionary -developmental model of middle childhood. Adrenarche is shown as a switch in the development of life history strategies, as well as a key mechanism underlying the normative changes of middle childhood and the emergence and intensification of sex differences. At a broader level, development in middle childhood serves two complementary functions, social integration and social competition

Middle Childhood: An Evolutionary-Developmental Synthesis.

Halfon N, Forrest CB, Lerner RM, et al., editors. Handbook of Life Course Health Development [Internet]. Cham (CH): Springer; 2018.
FIGURE 9-3Schematic representation of the impact of gonadal and adrenal hormones on reproductive strategies

NOTE: This diagram, loosely based on Ledoux (1998) and Zuckerman (1995) suggests that testosterone, DHEA/S, and cortisol all play different roles in brain mechanisms that underlie the expression of sexual behavior. Testosterone is related to the perception of sexual stimuli and associated sexual impulses. DHEA/S, on the other hand, is related to disinhibition of behavior in the precortex, whereas cortisol acts on the formulation of memories in the amygdala and hippocampus and the development of learned behavioral responses to sexual interaction.

Pubertal Maturation, Adrenarche, and the Onset of Reproduction in Human Males.

National Research Council (US) Panel for the Workshop on the Biodemography of Fertility and Family Behavior; Wachter KW, Bulatao RA, editors. Offspring: Human Fertility Behavior in Biodemographic Perspective. Washington (DC): National Academies Press (US); 2003.