Cover of Combination Use of Insulin and Incretins in Type 2 Diabetes

Combination Use of Insulin and Incretins in Type 2 Diabetes

CADTH Optimal Use Report, No. 3.1C

Copyright © CADTH 2013.
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The objective of this review was to summarize and critically appraise the evidence regarding the clinical effectiveness and harms of combination use of dipeptidyl peptidase-4 (DPP-4) inhibitors or glucagon-like peptide-1 (GLP-1) analogues with insulin. The following research questions were assessed:

  1. What is the clinical efficacy and safety of DPP-4 inhibitors used in combination with insulin for patients with inadequate glycemic control on a basal or biphasic insulin regimen?
  2. What is the clinical efficacy and safety of GLP-1 analogues used in combination with insulin for patients with inadequate glycemic control on a basal or biphasic insulin regimen?