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Monitoring Intervals
RECOMMENDATIONS |
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Periodic laboratory tests are necessary to evaluate the response to ART and its potential related side effects. In the setting of ART failure, viral resistance assays should be used.
Regular monitoring of CD4 counts in patients with consistently undetectable HIV viral loads and CD4 counts >200 cells/mm3 offers little utility in clinical practice today. Clinicians rarely use this information to guide decision-making for clinically stable, virologically suppressed patients. Monitoring of HIV RNA levels to confirm appropriate response to treatment and durable viral suppression is the most accurate and meaningful measure of the effectiveness of ART [Gale, et al. 2013].
Very few studies address the appropriate frequency of viral load monitoring. A recent retrospective study noted that the strongest predictor of virologic failure at 12 months was a missed or canceled appointment rather than the interval of follow-up [Buscher, et al. 2013]. However, this and other similar studies [Reekie, et al. 2008; Romih, et al. 2010] have significant limitations, including their retrospective nature and short follow-up periods. Data indicate that the linked sexual transmission of HIV in serodiscordant couples in which the HIV infected partner maintains sustained viral suppression is negligible [Rodger, et al. 2016]. Based on this information, persons with HIV may rely on their antiretroviral therapy as a strategy to prevent viral transmission to an uninfected partner. Studies do not indicate the appropriate interval for viral suppression monitoring for the purposes of ongoing transmission prevention. Until more definitive data are available, the decision to lengthen monitoring intervals for HIV RNA level should be individualized. Patients who are monitored at longer intervals should be carefully selected based on length of viral suppression, CD4 count, use of antiretroviral therapy for transmission prevention, and adherence to medical care, including visit attendance and retention in care.
KEY POINT
- Quarterly HIV RNA monitoring remains appropriate for patients with a recent history of non-adherence, mental health disorders, substance use, homelessness, poor social support system, or other major medical conditions. Semiannual monitoring may be appropriate for patients with persistently undetectable HIV RNA and none of the above characteristics.
Table 1 provides a guide for monitoring HIV RNA levels and CD4 counts.
Table 1: Virologic and Immunologic Monitoring for Non-Pregnant Patients [a]
At Baseline | HIV RNA Levels (copies/mL) | CD4 Lymphocyte Count (cells/mm3) |
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All patients |
|
|
Treatment Monitoring | HIV RNA Levels (copies/mL) | CD4 Lymphocyte Count (cells/mm3) |
Following (1) initiation of ART or (2) a change in ART regimen after virologic failure [b] with new resistance to prior ART |
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|
Following a change in ART to simplify treatment regimen or reduce toxicity for patients with suppressed virus |
|
|
Patients on ART who achieve complete suppression [c] |
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Patients on previously suppressive ART with new HIV RNA [d] above the lower limit of detection using a highly sensitive assay [c] | All patients:
| |
Patients not on ART: According to NYSDOH recommendations, ART is recommended for all patients with HIV [g] |
|
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Notes:
a. For monitoring HIV RNA levels and CD4 counts in pregnant women with HIV, see DHHS/AIDSinfo > Recommendations for the Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States.
b. Virologic failure is defined as the inability to achieve or maintain suppression of viral replication to an HIV RNA level <200 copies/mL [AIDSinfo 2019].
c. Complete suppression is generally considered below the lower limit of detection of a highly sensitive assay (<20 to <50 copies/mL).
d. Patients with repeated intermittent low-level viremia ≤200 copies/mL over a period of years without demonstrated failure may continue routine testing intervals.
e. ART should not be changed based on a single viral load elevation. The risk of virologic rebound (breakthrough) increases when values are >500 copies/mL [Grennan, et al. 2012].
f. Standard genotypic tests may not provide resistance results when viral load is low. For repeated low-level viremia, an assay that detects resistance mutations in archived proviral DNA is available; however, clinical data are insufficient to recommend for or against its use in the patient care setting.
g. See the NYSDOH AI guideline When to Initiate ART, With Protocol for Rapid Initiation.
Viral Load
Plasma HIV-1 RNA Level (Viral Load)
Plasma levels of viral RNA have been shown to correlate with clinical outcome, including overall mortality, and measurement of HIV RNA levels provides the most precise means of establishing whether a response to ART has occurred [Mellors, et al. 1997; Marschner, et al. 1998; Murray, et al. 1999; HIV Surrogate Marker Collaborative Group 2000; Thiebaut, et al. 2000]. HIV RNA levels should be obtained from all patients at baseline [Gulick, et al. 2003; Wu, et al. 2003; Tarwater, et al. 2004; Molina, et al. 2013; Behrens, et al. 2014; Porter, et al. 2015].
For patients beginning ART, or those changing therapy as a result of virologic failure, HIV RNA should be measured at 4 weeks after initiation of therapy and should decrease by at least 1 log (10-fold) in the presence of effective therapy [Haubrich, et al. 2011] (see Table 2: Interpretation of Viral Load, below). For patients who do not have background antiretroviral resistance, an undetectable viral load (<50 copies/mL) is usually achieved within 3 months. Patients with a baseline HIV viral load >100,000 copies/mL can be expected to achieve an undetectable viral load within 6 months of effective treatment.
An absent or incomplete response of viral load to ART should raise concerns about poor adherence to therapy and/or viral resistance [Baxter, et al. 2000; Townsend, et al. 2009].
Patients on previously suppressive ART with newly detectable HIV RNA levels of 50 to 500 copies/mL may be experiencing low-level transient viremia (“blip”) and not virologic failure. A blip by definition means that the viral load is again below the level of quantification on repeat testing performed promptly after a detectable result in someone previously suppressed. Persistent elevation, even at low levels, warrants further investigation. Acute concurrent illness and/or recent vaccination may cause this transient rise; however, studies have suggested that low-level transient viremia represents random biologic and statistical variation or false elevations of viral load resulting from laboratory processing [Nettles, et al. 2005; Lee, et al. 2006]. Blips are not known to be associated with the development of resistance mutations or virologic failure and do not require a change in ART [Lee, et al. 2006]. Retesting should be performed within 4 weeks to differentiate low-level transient viremia (a blip) from sustained viremia and possible virologic failure. The risk of virologic rebound (breakthrough) increases when values are >500 copies/mL [Grennan, et al. 2012]. However, ART should not be changed based on a single viral load elevation.
Advances in molecular detection technology have led to the development of HIV nucleic acid tests (NATs) that are highly sensitive and more reliable than earlier versions. Real-time polymerase chain reaction (PCR) technology has been widely adopted for HIV-1 RNA quantification, but new technologies are continually emerging and being adapted to viral detection and quantification. The currently available HIV-1 viral load tests that use real-time PCR technology offer larger dynamic range of quantification than early-version viral load tests. The lower and upper limits of quantification of the currently available FDA-approved HIV-1 viral load tests are shown in Table 3. Several different HIV viral load tests have been developed, and four are currently approved for use in the United States.
Table 3: FDA-Approved Quantitative HIV-1 RNA Assays for Viral Load Monitoring
Test Name | Method | Lower and Upper Limits of Quantification (LOQ) |
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Abbott RealTime HIV-1 (Abbott Laboratories) | Real-time PCR |
|
Cobas AmpliPrep/Cobas TaqMan HIV-1 Test, version 2.0 (Roche Diagnostics) | Real-time PCR |
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Cobas HIV-1 quantitative NAT for use on Cobas 6800/8800 systems (Roche Diagnostics) | Real-time PCR |
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Cobas TaqMan HIV-1 Test, v2.0 for use with the high pure system (Roche Diagnostics) | Real-time PCR |
|
- *
This lower LOQ applies when 1.0 mL of plasma is used. When 0.5 mL and 0.2 mL of plasma are used, the lower LOQ is 75 copies/mL and 150 copies/mL, respectively.
All of the current FDA-approved viral load assays quantify the level of cell-free virus in an individual’s plasma and are approved for monitoring response to ART, tracking viral suppression, and detecting treatment failure. Successful ART should decrease viral load 1.5 to 2 logs (30- to 100-fold) within 6 weeks, with the viral load decreasing below the limit of detection within 6 months [AIDSinfo 2019]. Cohort studies strongly suggest that patients with viral loads <50 copies/mL have more sustained viral suppression than patients with viral loads between 50 and 400 copies/mL. Assays that can detect <50 copies/mL are recommended for determining prolonged viral suppression and for monitoring patients who are on ART.
KEY POINT
- Achieving and maintaining an undetectable viral load is always the goal of ART.
CD4 Cell Count
Lymphocyte Subsets (CD4 Cell Count)
CD4 lymphocyte count is used to evaluate immunologic staging, predict the risk of clinical progression, and make decisions regarding prophylaxis of opportunistic infections [El-Sadr, et al. 2000; Lopez Bernaldo de Quiros, et al. 2001]. Low CD4 cell counts can be seen in other disease processes and should therefore not be used for diagnosis of HIV. Although, historically, CD4 cell count was used to establish a threshold for initiating ART, current guidelines in New York State recommend ART for all patients with HIV regardless of CD4 cell count. For patients who may not be ready to initiate ART, CD4 cell count can be used to guide discussions between patient and provider regarding the urgency of initiating ART.
Although CD4 counts should be obtained from patients at baseline [Fischl, et al. 1988; Schneider, et al. 1992; Havlir, et al. 1996; Oldfield, et al. 1998; Moore and Keruly 2007], clinicians are unlikely to use CD4 counts to guide clinical decision-making in practice for virologically suppressed patients once their CD4 count remains above 200 cells/mm3. However, for persons infected with HIV-2 or HIV-1 variants that cannot be accurately quantified using viral load assays, CD4 count remains the most effective monitoring tool for progression of disease (see the NYSDOH AI guideline HIV-2 Infection).
Although a significant CD4 count increase often occurs among patients treated with effective ART, the absence of such an increase should not be interpreted as treatment failure if the viral load declines appropriately. ART regimens are generally not changed in patients with undetectable viral loads who experience immunologic failure, although patients should remain on appropriate prophylaxis for opportunistic infections based on CD4 count. One study of a cohort of more than 62,000 individuals in New York City over 1.9 years of observation reported that in those who entered the cohort with a CD4 count ≥350 cells/mm3, there was a >90% likelihood of sustaining a CD4 count >200 cells/mm3 during that time period [Myers, et al. 2016]. Reassuringly, other data suggest that in patients with sustained viral suppression and CD4 counts between 100 cells/mm3 and 200 cells/mm3, risk of pneumocystis pneumonia is very low even in the absence of prophylaxis [D'Egidio, et al. 2007; Mocroft, et al. 2010; Chaiwarith, et al. 2013].
Lack of correlation between viral load and CD4 cell response is particularly common among patients ≥50 years old [Gras, et al. 2007; Sabin, et al. 2008] and patients with low initial CD4 cell counts (<100 cells/mm3) [Garcia, et al. 2004; Moore and Keruly 2007; Kelley, et al. 2009].
Absolute CD4 cell counts are calculated values that may fluctuate widely. The calculation is made by multiplying the total white blood cell count (in thousands) by the percentage of total lymphocytes and then by the percentage of CD4 lymphocytes. Therefore, any change in one of these three parameters will cause the absolute CD4 count to vary. CD4 percentage is a direct measurement and more reliable than the calculated absolute CD4 value, especially over time. A stable CD4 percentage, even in the setting of fluctuations in the absolute CD4 cell count, can reassure both the patient and the clinician that immunologic stability is present.
Some factors that can cause these fluctuations include sex, age, race, drugs (zidovudine, cephalosporins, cancer chemotherapy, nicotine, interferon, and corticosteroids), anti-lymphocyte antibodies, and splenectomy. Differences in reagents and equipment both within a laboratory and between laboratories may further contribute to variations in CD4 cell counts. There is also interlaboratory variation of normal range.
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