This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this report:

• Jeffrey A. Bluestone, Executive Vice Chancellor and Provost, University of California, San Francisco
• Walter M. Capone, Chief Operating Officer, Multiple Myeloma Research Foundation, Norwalk, CT
• Steven E. Hyman, Harvard Distinguished Service Professor; Professor of Stem Cell and Regenerative Biology, The Broad Institute, Cambridge, MA
• Gary Palmer, Senior Vice President, Medical Affairs and Commercial Development, Foundation Medicine, Inc., Cambridge, MA

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the report before its release. The review of this report was overseen by Melvin Worth.

Appointed by the Institute of Medicine, he was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the author and the institution.