Evidence Table 77. Sensitivity analyses of any increase in trials of polytherapy, high dose groups

Trials Included in Sensitivity AnalysisTrials RemovedRandom Effects Summary Effect Sizea (CI)P value
All trials included0.38 (0.23 to 0.53)0.000001
Largest effect size Anhut (1994) 0.36 (0.19 to 0.54)0.000042
Smallest effect size Sivenius (1991) 0.41 (0.26 to 0.57)0.000000
Largest sample size Anhut (1994) 0.39 (0.19 to 0.59)0.000127
Smallest sample size Sivenius (1991) 0.41 (0.26 to 0.57)0.000000
a

The effect size was Cohen's h. A positive effect size indicates that patients who received add-on drug were less likely to experience any seizure increase than patients who received add-on placebo.

From: Evidence Tables

Cover of Management of Treatment-Resistant Epilepsy
Management of Treatment-Resistant Epilepsy.
Evidence Reports/Technology Assessments, No. 77.
Chapell R, Reston J, Snyder D, et al.
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