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Cover of Developmental Biology

Developmental Biology, 6th edition


Swarthmore College
Sunderland (MA): Sinauer Associates; .
ISBN-10: 0-87893-243-7


Developmental biology is a great field for scientists who want to integrate different levels of biology. We can take a problem and study it on the molecular and chemical levels (e.g., How are globin genes transcribed, and how do the factors activating their transcription interact with one another on the DNA?), on the cellular and tissue levels (Which cells are able to make globin, and how does globin mRNA leave the nucleus?), on the organ and organ system levels (How do the capillaries form in each tissue, and how are they instructed to branch and connect?), and even at the ecological and evolutionary levels (How do differences in globin gene activation enable oxygen to flow from mother to fetus, and how do environmental factors trigger the differentiation of more red blood cells?).

Developmental biology is one of the fastest growing and most exciting fields in biology, creating a framework that integrates molecular biology, physiology, cell biology, anatomy, cancer research, neurobiology, immunology, ecology, and evolutionary biology. The study of development has become essential for understanding any other area of biology.


  • Preface
  • Acknowledgments
  • Part 1. Principles of development in biology
    • Chapter 1. Developmental biology: The anatomical tradition
      • The Questions of Developmental Biology
      • Anatomical Approaches to Developmental Biology
      • Comparative Embryology
      • Evolutionary Embryology
      • Medical Embryology and Teratology
      • Mathematical Modeling of Development
      • Principles of Development: Developmental Anatomy
      • References
    • Chapter 2. Life cycles and the evolution of developmental patterns
      • The Circle of Life: The Stages of Animal Development
      • The Frog Life Cycle
      • The Evolution of Developmental Patterns in Unicellular Protists
      • Multicellularity: The Evolution of Differentiation
      • Developmental Patterns among the Metazoa
      • Principles of Development: Life Cycles and Developmental Patterns
      • References
    • Chapter 3. Principles of experimental embryology
      • Environmental Developmental Biology
      • The Developmental Mechanics of Cell Specification
      • Morphogenesis and Cell Adhesion
      • Principles of Development: Experimental Embryology
      • References
    • Chapter 4. Genes and development: Techniques and ethical issues
      • The Embryological Origins of the Gene Theory
      • Evidence for Genomic Equivalence
      • Differential Gene Expression
      • RNA Localization Techniques
      • Determining the Function of Genes during Development
      • Identifying the Genes for Human Developmental Anomalies
      • Principles of Development: Genes and Development
      • References
    • Chapter 5. The genetic core of development: Differential gene expression
      • Differential Gene Transcription
      • Methylation Pattern and the Control of Transcription
      • Transcriptional Regulation of an Entire Chromosome: Dosage Compensation
      • Differential RNA Processing
      • Control of Gene Expression at the Level of Translation
      • Epilogue: Posttranslational Gene Regulation
      • Principles of Development: Developmental Genetics
      • References
    • Chapter 6. Cell-cell communication in development
      • Induction and Competence
      • Paracrine Factors
      • Cell Surface Receptors and Their Signal Transduction Pathways
      • The Cell Death Pathways
      • Juxtacrine Signaling
      • Cross-Talk between Pathways
      • Coda
      • Principles of Development:Cell-Cell Communication
      • References
  • Part 2. Early embryonic development
    • Chapter 7. Fertilization: Beginning a new organism
      • Structure of the Gametes
      • Recognition of Egg and Sperm
      • Gamete Fusion and the Prevention of Polyspermy
      • The Activation of Egg Metabolism
      • Fusion of the Genetic Material
      • Rearrangement of the Egg Cytoplasm
      • Snapshot Summary: Fertilization
      • References
    • Chapter 8. Early development in selected invertebrates
      • An Introduction to Early Developmental Processes
      • The Early Development of Sea Urchins
      • The Early Development of Snails
      • Early Development in Tunicates
      • Early Development of the Nematode Caenorhabditis elegans
      • References
    • Chapter 9. The genetics of axis specification in Drosophila
      • Early Drosophila Development
      • The Origins of Anterior-Posterior Polarity
      • The Generation of Dorsal-Ventral Polarity
      • References
    • Chapter 10. Early development and axis formation in amphibians
      • Early Amphibian Development
      • Axis Formation in Amphibians: The Phenomenon of the Organizer
      • References
    • Chapter 11. The early development of vertebrates: Fish, birds, and mammals
      • Early Development in Fish
      • Early Development in Birds
      • Early Mammalian Development
      • References
  • Part 3. Later embryonic development
    • Chapter 12. The central nervous system and the epidermis
      • Formation of the Neural Tube
      • Differentiation of the Neural Tube
      • Tissue Architecture of the Central Nervous System
      • Neuronal Types
      • Development of the Vertebrate Eye
      • The Epidermis and the Origin of Cutaneous Structures
      • Snapshot Summary: Central Nervous System and Epidermis
      • References
    • Chapter 13. Neural crest cells and axonal specificity
      • The Neural Crest
      • Neuronal Specification and Axonal Specificity
      • References
    • Chapter 14. Paraxial and intermediate mesoderm
      • Paraxial Mesoderm: The Somites and Their Derivatives
      • Myogenesis: The Development of Muscle
      • Osteogenesis: The Development of Bones
      • Intermediate Mesoderm
      • Snapshot Summary: Paraxial and Intermediate Mesoderm
      • References
    • Chapter 15. Lateral plate mesoderm and endoderm
      • Lateral Plate Mesoderm
      • Endoderm
      • References
    • Chapter 16. Development of the tetrapod limb
      • Formation of the Limb Bud
      • Generating the Proximal-Distal Axis of the Limb
      • Specification of the Anterior-Posterior Limb Axis
      • The Generation of the Dorsal-Ventral Axis
      • Coordination among the Three Axes
      • Cell Death and the Formation of Digits and Joints
      • Snapshot Summary: The Tetrapod Limb
      • References
    • Chapter 17. Sex determination
      • Chromosomal Sex Determination in Mammals
      • Chromosomal Sex Determination in Drosophila
      • Environmental Sex Determination
      • Snapshot Summary: Sex Determination
      • References
    • Chapter 18. Metamorphosis, regeneration, and aging
      • Metamorphosis: The Hormonal Reactivation of Development
      • Regeneration
      • Aging: The Biology of Senescence
      • References
    • Chapter 19. The saga of the germ line
      • Germ Plasm and the Determination of the Primordial Germ Cells
      • Germ Cell Migration
      • Meiosis
      • Spermatogenesis
      • Oogenesis
      • Snapshot Summary: The Germ Line
      • References
  • Part 4. Ramifications of developmental biology
    • Chapter 20. An overview of plant development
      • Plant Life Cycles
      • Gamete Production in Angiosperms
      • Pollination
      • Fertilization
      • Embryonic Development
      • Dormancy
      • Germination
      • Vegetative Growth
      • The Vegetative-to-Reproductive Transition
      • Senescence
      • Snapshot Summary: Plant Development
      • References
    • Chapter 21. Environmental regulation of animal development
      • Environmental Regulation of Normal Development
      • Environmental Disruption of Normal Development
      • References
    • Chapter 22. Developmental mechanisms of evolutionary change
      • “Unity of Type” and “Conditions of Existence”
      • Hox Genes: Descent with Modification
      • Homologous Pathways of Development
      • Modularity: The Prerequisite for Evolution through Development
      • Developmental Correlation
      • Developmental Constraints
      • A New Evolutionary Synthesis
      • Snapshot Summary: Evolutionary Developmental Biology
      • References
  • Appendix

With a chapter on Plant Development by Susan R Singer, Carleton College

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 2000, Sinauer Associates.
Bookshelf ID: NBK9983


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