Figure 5.24. Nucleotide-excision repair of thymine dimers.

Figure 5.24Nucleotide-excision repair of thymine dimers

Damaged DNA is recognized and then cleaved on both sides of a thymine dimer by 3′ and 5′ nucleases. Unwinding by a helicase results in excision of an oligonucleotide containing the damaged bases. The resulting gap is then filled by DNA polymerase and sealed by ligase.

From: DNA Repair

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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