Table 3Cyanation of the Bromoisoxazole Analog of the Probe (CID 3689413/ML210)

EntryPd Cat.LigandCyanide SourceAdditiveConditionsResult
1Pd2(dba)3dppfZn(CN)2 0.6 eq.Zn 0.24 eq.DMF, 120 °C, 48 hUndesirable byproduct (reductive ring opening of isoxazole)
2Pd2(dba)3dppfCuCN 4 eq.-Dioxane, 101 °C, 48 hPoor conversion to undesirable byproduct

From: Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

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